Laterally spreading tumor: Clinicopathological study in comparison with the depressed type of colorectal tumor

Ohno, Yasuhiko; Terai, Takeshi; Ogihara, Tatsuo; Hirai, Shu; Miwa, Hiroto

doi:10.1046/j.1440-1746.2001.02512.x

Cited by 13 publications

(16 citation statements)

References 14 publications

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“…It has a tendency to affect the rectum, sigmoid colon, and caecum. In some studies, it has been reported that the carcinogenesis rate of LST is 8.64%-52.5% [13][14][15] .…”

Section: Introductionmentioning

confidence: 99%

“…It has a tendency to affect the rectum, sigmoid colon, and caecum. In some studies, it has been reported that the carcinogenesis rate of LST is 8.64%-52.5% [13][14][15] . Abstract AIM: To study the molecular mechanism of laterally spreading tumor (LST), a cell line [Laterally Spreading Tumor-Rectum 1 (LST-R1)] was derived and the characteristics of this cell line were investigated.…”

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confidence: 99%

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Establishment and characterization of a new cell line derived from human colorectal laterally spreading tumor

Wang¹,

Lai²,

Yeung³

et al. 2008

WJG

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CONCLUSION:We established and characterized a colorectal cancer cell line, LST-R1 and LST-R1 has an obvious malignant tendency, which maybe partially attributed to the changes of the expression of some adhesion molecules, such as E-cadherin. It is also a versatile tool for exploring the original and progressive mechanisms of laterally spreading tumor and the early colon cancer genesis. INTRODUCTIONTwo routes have been described that can lead to colon carcinogenesis: one is the adenoma-carcinoma model, which is the main carcinogenetic pathway of prudent colorectal tumor and has been widely accepted in the west. However, an increasing number of superficial or flat colorectal tumors have been reported, particular in Japan [1,2] . The superficial tumors are considered to have a distinct clinicopathologic, genetic feature and behave a different carcinogenetic pathway, called de novo pathway [3][4][5][6] . Laterally spreading tumor (LST) is a unique subtype of superficial colorectal tumor, which was first reported by Kudo S in 1993 [7,8] and many names such as granular cluster type, nodule-aggregating tumor, creeping tumor, superficial spreading (epithelial) tumor, flower-bed-like lesion had been used. In 1998, it was defined as tumors originated from the colorectal mucous membranes and mainly extends laterally rather than vertically with its diameter greater than 1 cm ( Figure 1A) [9][10][11][12] . It has a tendency to affect the rectum, sigmoid colon, and caecum. In some studies, it has been reported that the carcinogenesis rate of LST is 8.64%-52.5% [13][14][15] . Abstract AIM: To study the molecular mechanism of laterally spreading tumor (LST), a cell line [Laterally Spreading Tumor-Rectum 1 (LST-R1)] was derived and the characteristics of this cell line were investigated. BASIC RESEARCH METHODS:A new cell line (LST-R1) originated from laterally spreading tumor was established. Properties of the cell line were characterized using scanning and transmission electron microscopy, immunohistochemistry method, cytogenetic analysis and nude mice xenograft experiments. In vitro invasion assay, cDNA microarray and Western blotting were used to compare the difference between the LST-R1 and other colorectal cancer cell lines derived from prudent colon cancer. RESULTS:Our study demonstrated that both epithelial special antigen (ESA) and cytokeratin-20 (CK20) were expressed in LST-R1. The cells presented microvilli and tight junction with large nuclei. The karyotypic analysis showed hyperdiploid features with structural chromosome aberrations. The in vivo tumorigenicity was also demonstrated in nude mice xenograft experiments. The invasion assay suggested this cell line has a higher invasive ability. cDNA microarray and Western blotting show the loss of the expression of E-cadherin in LST-R1 cells.

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“…It has a tendency to affect the rectum, sigmoid colon, and caecum. In some studies, it has been reported that the carcinogenesis rate of LST is 8.64%-52.5% [13][14][15] .…”

Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 99%

Establishment and characterization of a new cell line derived from human colorectal laterally spreading tumor

Wang¹,

Lai²,

Yeung³

et al. 2008

WJG

View full text Add to dashboard Cite

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“…1). [1][2][3][4][5] All patients underwent preoperative colonoscopy with biopsy of the tumor and colonoscopic ultrasonography. Metallic clips were placed as markers by preoperative colonoscopy.…”

Section: Laterally Spreading Tumors (Lsts)mentioning

confidence: 99%

“…Colectomy with regional lymph node dissection was performed for tumors considered to have submucosal invasion on the basis of endoscopic findings. 4,5 All steps of the minilaparotomy approach were done using conventional surgical techniques and instruments via a small abdominal incision no longer than 7 cm. 14 The surgical technique used to perform limited colectomy or colectomy with regional lymph node dissection through a minilaparotomy was previously described.…”

Section: Operative Technique Of the Minilaparotomy Approachmentioning

confidence: 99%

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Minilaparotomy Approach for the Resection of Laterally Spreading Tumors of the Colon

et al. 2004

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Diagnostic significance of gently sloping depression and irregular margin in superficial elevated colorectal tumors

Nakahara

Aoyama

Maekawa

et al. 2006

Int J Colorectal Dis

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Laterally spreading tumor: Clinicopathological study in comparison with the depressed type of colorectal tumor

Abstract: It seems appropriate that these LSTs with depression should be distinguished from depressed-type colorectal tumors and regarded as constituting a new clinical entity.

Cited by 13 publications

References 14 publications

Establishment and characterization of a new cell line derived from human colorectal laterally spreading tumor

Establishment and characterization of a new cell line derived from human colorectal laterally spreading tumor

Minilaparotomy Approach for the Resection of Laterally Spreading Tumors of the Colon

Diagnostic significance of gently sloping depression and irregular margin in superficial elevated colorectal tumors

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