Latest research progress in the correlation between baicalein and breast cancer invasion and metastasis

Yan, Wanjun; Ma, Xingcong; Gao, Xiaoyan; Xue, Xing-Huan; Zhang, Shu‐Qun

doi:10.3892/mco.2016.750

Cited by 16 publications

(12 citation statements)

References 46 publications

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“…BCL activity was quite modest in our experiments and those data were similar to previous findings. Yan et al [ 39 ] established the EC 50 for BCL against the MCF-7 cell line as 66.3 ± 5.9 µM, and Lee [ 40 ] found that BCL reduced the lung cancer cell line CH27 viability at 50 µM concentration.…”

Section: Resultsmentioning

confidence: 99%

Relationship between Antioxidant and Anticancer Activity of Trihydroxyflavones

2017

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Plant polyphenols have been highlighted not only as chemopreventive, but also as potential anticancer substances. Flavones are a subclass of natural flavonoids reported to have an antioxidant and anticancer activity. The aim of our study was to evaluate antioxidant and anticancer activity of seventeen trihydroxyflavone derivatives, including apigenin (API) and baicalein (BCL). Also, we wanted to find out if there is a correlation between those two effects. Cell growth inhibition testing was carried out using MTT assay in three different human cancer cell lines: lung (A549), breast (MCF-7) and brain epithelial (U87). Antioxidant activity was determined by the DPPH radical scavenging method. Thirteen trihydroxyflavones possessed anticancer activity against at least one tested cancer cell line. They were more active against the MCF-7 cell line, and the lowest activity was determined against the U87 cell line. The majority of compounds inhibited cancer cell growth at EC50 values between 10–50 µM. The most active compound was 3’,4’,5-trihydroxyflavone 7, especially against A549 and MCF-7 cell lines. The correlation between anti-proliferative and antioxidant activity was only moderate, and it was determined for A549 and U87 cancer cell lines. The most important fragment for those two effects is the ortho-dihydroxy group in ring B. Conclusions. Trihydroxyflavones demonstrated anticancer activity. Further and more detailed studies should to be carried out to estimate the structure–activity relationship of these compounds.

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Section: Resultsmentioning

confidence: 99%

Relationship between Antioxidant and Anticancer Activity of Trihydroxyflavones

2017

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“…Traditional herbal medicines have long been used to treat various diseases . Some critical components of medical herbs have been identified and show attractive anti‐cancer effects in many cancers, including breast cancer .…”

Section: Introductionmentioning

confidence: 99%

“…5,6 Traditional herbal medicines have long been used to treat various diseases. 7 Some critical components of medical herbs have been identified and show attractive anti-cancer effects in many cancers, including breast cancer. 8 Baicalein (5,6,7trihydroxyflavone) is a flavonoid derived from the root of Scutellaria baicalensis Georgi and has defined chemical structure.…”

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confidence: 99%

Baicalein inhibits breast cancer growth via activating a novel isoform of the long noncoding RNA PAX8‐AS1‐N

Cao

Tang

et al. 2018

J of Cellular Biochemistry

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Baicalein, a natural flavonoid, has fascinating anti-cancer properties in breast cancer. Long noncoding RNAs (lncRNAs), a class of transcripts with no protein-coding potential, also exhibit critical roles in breast cancer. However, the molecular mechanisms mediating the anti-cancer properties of baicalein and whether lncRNAs are involved in the anti-cancer effects are still unclear. In this study, we identified a novel isoform of lncRNA PAX8-AS1 (PAX8-AS1-N), which is activated by baicalein in a dose- and time-dependent manner. Functional assays showed that PAX8-AS1-N reduced cell viability, inhibited cell-cycle progression, and induced apoptosis of breast cancer cells in vitro. Depletion of PAX8-AS1-N promoted breast xenograft tumor growth in vivo. Furthermore, depletion of PAX8-AS1-N attenuated the suppressive roles of baicalein on cell viability, the apoptosis induced by baicalein, and also the suppressive roles of baicalein on tumor growth in vivo. Mechanistically, PAX8-AS1-N bound to miR-17-5p, and up-regulated miR-17-5p targets, such as PTEN, CDKN1A, and ZBTB4. In addition, PAX8-AS1-N was down-regulated in breast cancer and reduced expression of PAX8-AS1-N indicated poor survival of breast cancer patients. In conclusion, our results demonstrated that PAX8-AS1-N activation mediated the anti-cancer effects of baicalein via regulating miR-17-5p, and suggested that baicalein and enhancing PAX8-AS1-N would be potential therapeutic strategies against breast cancer.

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“…The root of Scutellariae baicalensis Georgi is used to treat some diseases, such as hypertension, bacterial and viral infections, and inflammation, and baicalin is one of the main bioactive components of this root. Previous studies reported that baicalin downregulated the concentration of several cytokines and proteins, such as tumor necrosis factor-α (TNF-α), immunoglobulin E (IgE), interleukin-6 (IL-6), and interleukin-1β (IL-1β), to ameliorate inflammatory disorders and tissue injury [17][18][19]. Baicalin also effectively reduced oxidative stress and apoptosis via the Nrf2 pathway [20,21].…”

Section: Introductionmentioning

confidence: 99%

Baicalin-Copper Complex Modulates Gut Microbiota, Inflammatory Responses, and Hormone Secretion in DON-Challenged Piglets

Zha

Cui

et al. 2020

Animals

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The present experiment assessed the inflammatory responses, hormone secretion, and gut microbiota of weanling piglets administered baicalin-copper complex (BCU) or deoxynivalenol (DON) supplementation diets. Twenty-eight piglets were randomly assigned to four groups: control diet (Con group), a 4 mg DON/kg diet (DON group), a 5 g BCU/kg diet (BCU group), a 5 g BCU + 4 mg DON/kg diet (DBCU group). After 14 days, the results showed that dietary BCU supplementation remarkably increased the relative abundance of Clostrium bornimense and decreased the relative abundance of Lactobacillus in the DBCU group (p < 0.05). BCU decreased the serum concentration of IgG, IL-2, IFN-γ, and IgA in DON treated piglets (p < 0.05), and promoted the serum concentration of IL-1β, IgG, IL-2, IFN-γ, IgA, IL-6, IgM, and TNFα in normal piglets (p < 0.05). BCU increased the concentrations of serum IGF1, insulin, NPY, GLP-1, and GH, and decreased the concentrations of serum somatostatin in no DON treated piglets (p < 0.05). Dietary BCU supplementation significantly promoted the secretion of somatostatin, and inhibited the secretion of leptin in piglets challenged with DON (p < 0.05). BCU regulated the expression of food intake-related genes in the hypothalamus and pituitary of piglets. Collectively, dietary BCU supplementation alleviated inflammatory responses and regulated the secretion of appetite-regulating hormones and growth-axis hormones in DON challenged piglets, which was closely linked to changes of intestinal microbes.

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Latest research progress in the correlation between baicalein and breast cancer invasion and metastasis

Cited by 16 publications

References 46 publications

Relationship between Antioxidant and Anticancer Activity of Trihydroxyflavones

Relationship between Antioxidant and Anticancer Activity of Trihydroxyflavones

Baicalein inhibits breast cancer growth via activating a novel isoform of the long noncoding RNA PAX8‐AS1‐N

Baicalin-Copper Complex Modulates Gut Microbiota, Inflammatory Responses, and Hormone Secretion in DON-Challenged Piglets

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