Latex Rubber Capsule for Producing Hypertension in Rats by Perinephritis

Abrams, Morris; Sobin, Sidney S.

doi:10.3181/00379727-64-15811

Cited by 34 publications

(5 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…At the end of the control period, the rats were divided randomly into the appropriate groups. Bilateral renal encapsulation was performed by the technique of Abrams and Sobin [ 1 ] using latex rubber capsules molded to be 1.5-2.0 times the size of the kidneys. All rats were anesthetized with sodium pentobarbital (40 mg/kg, i.p.)…”

Section: Methodsmentioning

confidence: 99%

Effect of Chronic Dietary Treatment with L-Tryptophan on the Development of Renal Hypertension in Rats

Fregly¹,

Lockley²,

Cade³

1988

Pharmacology

View full text Add to dashboard Cite

Chronic dietary administration of L-tryptophan (2.5 and 5.0 g/100 g food) to rats provided significant protection against the development of hypertension induced by bilateral encapsulation of the kidneys with latex envelopes. Lower doses of tryptophan (0.5 and 1.0 g/100 g food) attenuated the rate of elevation of blood pressure, but failed to maintain systolic blood pressures at levels significantly below that of untreated renal hypertensive controls. The body weight of the rats was not affected significantly by treatment with any dose of tryptophan used. Chronic treatment with tryptophan also protected against the reduced urinary concentrating ability during a 24-hour dehydration that characteristically accompanies renal encapsulation. A modest (5–8%) effect of treatment to reduce cardiac hypertrophy was also observed. The mechanism of the antihypertensive effect of tryptophan is not revealed by these studies although they rule out the possibilities that reduction in sodium intake and/or reduction in body weight may be important factors.

show abstract

Section: Methodsmentioning

confidence: 99%

Effect of Chronic Dietary Treatment with L-Tryptophan on the Development of Renal Hypertension in Rats

Fregly¹,

Lockley²,

Cade³

1988

Pharmacology

View full text Add to dashboard Cite

show abstract

“…Hypertension 53 male Wistar rats, weighing approximately 180 g, were divided at random into two groups. 32 rats were made hypertensive by bilateral encapsulation of their kidneys with latex envelopes [2]. This procedure was carried out while the animals were anesthetized with ether.…”

Section: Methodsmentioning

confidence: 99%

Interrelationships among Blood Pressure, Renal Function, Thyroid Activity and Renal Thyroid Depressing Factor in Renal Hypertensive Rats

Threatte¹,

Fregly²,

Field³

1982

Pharmacology

View full text Add to dashboard Cite

Renal hypertension in rats was accompanied by both a decrease in thyroid activity (i.e., decreased total serum triiodothyronine concentration, increased serum thyroid-stimulating hormone concentration and increased thyroid weight) and renal function (i.e., reduced renal concentrating ability, increased blood urea nitrogen and serum creatinine concentrations). Systolic blood pressure, thyroid activity and level of renal function of individual hypertensive rats correlated significantly with the content of a thyroid-depressing factor in their kidneys. The results suggest, but do not prove, that a factor released by the kidneys during elevation of blood pressure and/or reduction in renal function may reduce thyroid function in the rat.

show abstract

“…Blood pressure, heart rate and plasma renin activity (PRA) studies in conscious renal hypertensive dogs Adult male beagles weighing 12.75 to 16kg were previously made hypertensive by renal encapsu-0 11 NS Me N Me Figure 1 The chemical structure of flosequinan (BTS 49 465, 7-fluoro-1-methyl-3-methylsulphinyl-4quinolone). lation by latex capsule, using a technique similar to that described for the rat (Abrams & Sobin, 1947). The experiments in this study were carried out 9 to 17 months after renal encapsulation.…”

Section: Studies In the Dogmentioning

confidence: 99%

Cardiovascular effects of the novel arteriovenous dilator agent, flosequinan in conscious dogs and cats

Sim

Yates

Parkinson

et al. 1988

British J Pharmacology

View full text Add to dashboard Cite

1 Flosequinan (BTS 49 465, 7-fluoro-1-methyl-3-methylsulphinyl-4-quinolone) a novel arteriovenous dilator agent was orally effective in conscious renal hypertensive dogs and normotensive cats. The hypotensive potency of flosequinan was approximately ten times less than that of hydralazine in renal hypertensive dogs, 10mgkg-1 and 20mgkg-1 flosequinan causing similar falls in mean blood pressure to mg kg-I and 3 mg kg-1 hydralazine respectively. In normotensive cats, 5 mgkg 1 flosequinan caused similar falls to 0.5 and 1.Omgkg 1 hydralazine. The onset of hypotensive effect after flosequinan appeared to be slightly slower than after hydralazine in the dog and slightly faster than hydralazine in the cat. 2 The degree of tachycardia and increase in plasma renin activity (PRA) for equivalent falls in mean blood pressure in both species was significantly less for flosequinan than for hydralazine (P < 0.05). 3 In normotensive dogs, flosequinan, 10 and 2Omgkg-1 orally, caused a small but non-significant increase in sodium and chloride excretion and had little effect on urine volume whereas hydralazine, 1 and 3 mg kg1-orally, caused a marked retention of sodium and chloride ions and a reduction in urine volume (P < 0.01). 4 Neither flosequinan, 10mgkg-1 orally, nor hydralazine 1mgkg-1 orally, affected either glomerular filtration rate measured as creatinine clearance or effective renal plasma flow measured as p-aminohippuric acid clearance in normotensive dogs. 5 The lesser degree of tachycardia and increase in plasma renin activity together with a lack of sodium retaining activity associated with flosequinan suggest that this agent may have potential advantages over existing therapy as an antihypertensive in man.

show abstract

Latex Rubber Capsule for Producing Hypertension in Rats by Perinephritis

Cited by 34 publications

References 0 publications

Effect of Chronic Dietary Treatment with L-Tryptophan on the Development of Renal Hypertension in Rats

Effect of Chronic Dietary Treatment with L-Tryptophan on the Development of Renal Hypertension in Rats

Interrelationships among Blood Pressure, Renal Function, Thyroid Activity and Renal Thyroid Depressing Factor in Renal Hypertensive Rats

Cardiovascular effects of the novel arteriovenous dilator agent, flosequinan in conscious dogs and cats

Contact Info

Product

Resources

About