Lauric Acid as Potential Natural Product in the Treatment of Cardiovascular Disease: A Review

D, Christopher V Sobarani

doi:10.4172/1948-593x.1000107

Cited by 1 publication

(1 citation statement)

References 11 publications

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“…It is a medium-chain fatty acid (MCFA) found abundantly in the coconut oil, palm kernel oil and laurel oil, which constitutes about half of the fatty acid (Beare-Rogers, Dieffenbacher & Holm, 2001;Ubgogu, Onyeagba & Chigbu, 2006). It is also found in various kinds of foods, such as fruits, seeds, and breast milk (Alves et al, 2017;Silberstein et al, 2013;Uday Kumar et al, 2014). It possesses pleiotropic biological activities, including potent anti-microbial effects (Dayrit, 2015), beneficial effect on the cardiovascular system (CVS) by increasing high-density lipoproteins (HDL) and reducing blood pressure and heart rate in hypertensive rats (Ahola et al, 2017).…”

Section: Introductionmentioning

confidence: 99%

Food additive “lauric acid” possess non-toxic profile on biochemical, haematological and histopathological studies in female Sprague Dawley (SD) rats

Khan

Aamir

Sisinthy

et al. 2020

PeerJ

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Background Lauric acid (LA), a common constituent of coconut oil, is used as food additives and supplements in various formulations. Despite various potential pharmacological properties, no scientific evidence on its dose-related toxicity and safety is available till date. Objective The current study was conducted to evaluate acute oral toxicity of LA on normal rats. Methods The study was conducted in accordance with the Organization for Economic Co-operation and Development guidelines (OECD 423) with slight modifications. LA was administered orally to female Sprague Dawley (SD) rats (n = 6/group) at a single dose of 300 and 2,000 mg/kg body weight, respectively, while normal control received vehicle only. Animals from all the three groups were monitored for any behavioural and toxicological changes and mortality for two weeks. Food and fluid consumption, body weight was monitored on daily basis. At the end (on day 15th) of the experimental period, blood was collected for haematological and biochemical analysis. Further, all the animals were euthanized, and internal organs were harvested for histopathological investigation using four different stainings; haematoxylin and eosin, Masson trichrome, Periodic Acid Schiff and Picro Sirius Red for gross pathology through microscopical observation. Results The study results showed no LA treatment-related mortality and morbidity at two different dosages. Daily food and water consumption, body weight, relative organ weight, haematological, and biochemical analysis were observed to be normal with no severe alterations to the internal tissues. Conclusion The current finding suggests that single oral administration of LA, even up to 2,000 mg/kg body weight, did not exhibit any signs of toxicity in SD rats; thus, it was safe to be used on disease models in animals.

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