Lavender and peppermint essential oils as effective mushroom tyrosinase inhibitors: a basic study

Abstract

Screening and characterization of novel tyrosinase inhibitors is useful for applications in food technology,\ud cosmetics and medicine. The hydrodistilled essential oils from lavender Lavandula spica L. and peppermint Mentha x piperita L.\ud were investigated for tyrosinase inhibitory activity. Their composition was assessed by gas chromatography–mass\ud spectrometry. Both oils inhibited mushroom tyrosinase in a dose dependent manner. The IC50 values were estimated,\ud kinetics were analysed and Ki values were determined. Our results indicate that lavender and peppermint essential oils\ud may be promising herbal ingredients for developing depigmenting agents in clinical, cosmetic and industrial processes

Phenolic composition, in vitro antioxidant effects and tyrosinase inhibitory activity of three Algerian Mentha species: M. spicata (L.), M. pulegium (L.) and M. rotundifolia (L.) Huds (Lamiaceae)

“…Previous works on Mentha piperita indicate that its essential oil also inhibits the mushroom tyrosinase (IC 50 , 240 g/mL) (Fiocco et al, 2011) and may cause inactivation or inhibition of the insect tyrosinase which results in incomplete cuticle hardening and darkening (El Nagar et al, 2012). Fiocco et al (2011) concluded that Mentha essential oils are promising herbal ingredients for developing depigmenting agents in clinical, cosmetic and industrial processes; our data indicate that total extracts (polyphenols) may be even more interesting ingredients.…”

Chemical Composition and the Potential of Lavandula angustifolia L. Oil as a Skin Depigmentant

“…Also the P value beingtypically < 0.05 is significant, meaning that our results indicate a melanin decrease worth of consideration, especially inside the melanine macula This evolution is presented in the Figure S1 in Supporting information file. Lavandula angustifolia essential oil was cited in literature for its tyirosinasis inhibitory property [7,8,22,23]. This effect was demonstrated for the botanical world, on fungi.…”

“…Fiocco, D. et al, 2011 which constituted our premise, has not yet advanced any explanation on the relationship between chemical structure and antithyrosinase activity, namely, it does not express which substance in the composition of Lavandula angustifolia essential oil inhibits or blocks tyrosinase [7].…”

“…Extrapolating the encouraging result of Fiocco et al 2011 and 2016 [7,8] and knowing that in the human body, tyrosinase is the key enzyme of melanogenesis, the present study attempts to highlight whether this biochemical property (inhibition of tyrosinase by lavender oil) would also have a beneficial impact on melanogenesis. The result could be encouraging and favorable, because after the worldwide avoidance of hydroquinone (due to its significant toxic potential), the other potential natural blockers of tyrosinase have a mediocre clinical effect, requiring continued and stronger, or synergistic use of those highlighted to date.…”

“…In the fungi, tyrosinase plays a different biological role than in the human body. In plants and fungi, tyrosinase can oxidize a variety of phenolic compounds, leading to the undesirable effect of blackening of fruits and vegetables, causing a degradation both on nutritional quality and on the commercial value of commodities [7]. Because of this, depigmenting agents are highly sought after in agriculture and the food technology industry.…”