Layer by Layer Antimicrobial Coatings Based on Nafion, Lysozyme, and Chitosan

Gibbons, Ella Nicole; Winder, Charis Isobel; Barron, Elliot; Fernandes, Diogo; Krysmann, Marta J.; Kelarakis, Antonios; Parry, Adam V. S.; Yeates, Stephen G.

doi:10.3390/nano9111563

Cited by 19 publications

(17 citation statements)

References 47 publications

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“…As in several systems prepared via a layer by layer approach [37][38][39][40], the proposed surface modification proceeds with a simple electrostatic deposition, in this case on an APTES functionalized glass surface. The approach proposed here may offer several advantages: CuS NP are easy to prepare and almost inexpensive, especially when compared to noble metal nanoparticles or synthetic antibacterial moieties that have to be grafted to surfaces.…”

Section: Discussionmentioning

confidence: 99%

Self-Assembled Monolayers of Copper Sulfide Nanoparticles on Glass as Antibacterial Coatings

et al. 2020

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We developed an easy and reproducible synthetic method to graft a monolayer of copper sulfide nanoparticles (CuS NP) on glass and exploited their particular antibacterial features. Samples were fully characterized showing a good stability, a neat photo-thermal effect when irradiated in the Near InfraRed (NIR) region (in the so called “biological window”), and the ability to release controlled quantities of copper in water. The desired antibacterial activity is thus based on two different mechanisms: (i) slow and sustained copper release from CuS NP-glass samples, (ii) local temperature increase caused by a photo-thermal effect under NIR laser irradiation of CuS NP–glass samples. This behavior allows promising in vivo applications to be foreseen, ensuring a “static” antibacterial protection tailored to fight bacterial adhesion in the critical timescale of possible infection and biofilm formation. This can be reinforced, when needed, by a photo-thermal action switchable on demand by an NIR light.

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Section: Discussionmentioning

confidence: 99%

Self-Assembled Monolayers of Copper Sulfide Nanoparticles on Glass as Antibacterial Coatings

et al. 2020

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“…2a-d indicate the spherical nature of CU03D, CU25D, CU50D and CU100D nanoparticles with diameters in the range of 10-15 nm. Previous studies suggested that the size of C-dots derived from CA/urea mixtures varies from 2 to 11 nm [31][32][33][34][35][36][37][38][39][40][41][42][43]. The XRD patterns of the four members of D-series (Fig.…”

Section: Resultsmentioning

confidence: 88%

A Rich Gallery of Carbon Dots based Photoluminescent Suspensions and Powders Derived by Citric acid/urea

Kelarakis¹,

Krysmann²,

Stachowska³

et al. 2021

Preprint

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In this study we demonstrate simple guidelines to generate a diverse range of fluorescent materials in both liquid and solid state by focusing on the most popular C-dots precursors, i.e. the binary systems of citric acid and urea. The pyrolytic treatment of those precursors combined with standard size separation techniques (dialysis and filtration), leads to four distinct families of photoluminescent materials in which the emissive signal predominantly arises from C-dots with embedded fluorophores, cyanuric acid-rich C-dots, a blend of molecular fluorophores and a mixture of C-dots with unbound molecular fluorophores, respectively. Within each one of those families the chemical composition and the optical properties of their members can be fine-tuned by adjusting the molar ratio of the reactants. Apart from generating a variety of aqueous dispersions, our approach leads to highly fluorescent powders derived from precursors comprising excessive amounts of urea that is consumed for the build-up of the carbogenic cores, the molecular fluorophores and the solid diluent matrix that suppresses self-quenching effects.

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“…The results show that the growth of the film mass is linear for the PLL/Nafion deposition, which is in agreement with the limited data available in the literature concerning the growth mode previously observed for other pairs of polycation/Nafion. 9 , 10 However, the polymer mass increment during the deposition step was higher for the Nafion layer than for the PLL one.…”

Section: Resultsmentioning

confidence: 96%

Nafion-Based Nanocarriers for Fluorine Magnetic Resonance Imaging

et al. 2020

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The aim of our study was to develop a novel method for nanocarriers’ preparation as a fluorine magnetic resonance imaging ( 19 F MRI)-detectable drug delivery system. The novelty of the proposed approach is based on the application of fluorinated polyelectrolyte Nafion as a contrast agent since typical MRI contrast agents are based on paramagnetic gadolinium or ferro/superparamagnetic iron oxide compounds. An advantage of using an 19 F-based tracer comes from the fact that the 19 F image is detected at a different resonance frequency than the 1 H image. In addition, the close to zero natural concentration of 19 F nuclei in the human body makes fluorine atoms a promising MRI marker without any natural background signal. That creates the opportunity to localize and identify only exogenous fluorinated compounds with 100% specificity. The nanocarriers were formed by the deposition of polyelectrolytes on nanoemulsion droplets via the layer-by-layer technique with the saturation approach. The polyelectrolyte multilayer shell was composed of Nafion, the fluorinated ionic polymer used for labeling by 19 F nuclei, and poly- l -lysine (PLL). The surface of such prepared nanocarriers was further pegylated by adsorption of pegylated polyanion, poly- l -glutamic acid (PGA). The 19 F MRI-detectable hydrophobic nanocarriers with an average size of 170 nm and a sufficient signal-to-noise ratio have been developed and optimized to be used for passive tumor targeting and drug delivery.

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Layer by Layer Antimicrobial Coatings Based on Nafion, Lysozyme, and Chitosan

Cited by 19 publications

References 47 publications

Self-Assembled Monolayers of Copper Sulfide Nanoparticles on Glass as Antibacterial Coatings

Self-Assembled Monolayers of Copper Sulfide Nanoparticles on Glass as Antibacterial Coatings

A Rich Gallery of Carbon Dots based Photoluminescent Suspensions and Powders Derived by Citric acid/urea

Nafion-Based Nanocarriers for Fluorine Magnetic Resonance Imaging

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