Layer‐by‐Layer Assembled Smart Antibacterial Coatings via Mussel‐Inspired Polymerization and Dynamic Covalent Chemistry

Abstract

Bacterial colonization on the surface of medical implanted devices and bacterial infection-induced biofilm have been a lethal risk for patients of clinical treatment. While antibacterial coatings fabricated by layer-by-layer (LBL) assembly techniques have been well explored, the facile preparation of substrate-independent smart antibacterial coatings with on-demand antibiotics release profile and excellent antibacterial performance is still urgently needed. In this work, this goal is addressed by LBL assembly fabrication of robust antibacterial coatings using naturally occurring and commercially available building blocks (i.e., aminoglycosides, 5,6-dihydroxyindole, and formylphenylboronic acid) via the subsequentially performed mussel-inspired polymerization and dynamic covalent chemistries. The resulting antibacterial coatings on different substates all presente a dynamic feature (i.e., pH-responsive), on-demand antibiotics release properties, and highly effective antibacterial performance both in vitro and in vivo. It is envisioned that this work can expand the scope of LBL assembly technique toward the next generation of robust and universal antibacterial coating materials by using natural building blocks and readily available chemistries.

Robust Natural Polyphenolic Adhesives against Various Harsh Environments

“…As shown in Figure e, the gelation time of the polyphenol-epoxy hydrogel was different owing to the distinct content of phenolic hydroxyl. Notably, the gelation time of NGDE hydrogel was longer than BDE, which may be attributed to the strong hydrophobic interaction of methyl with water. , …”

Smart Internal Bio‐Glues

“…XPSPEAK software (version 4.1) was used to deconvolute the narrow-scan XPS spectra of C 1s , O 1s , N 1s , F 1s , Y 3d , Na 1s , Yb 4d , and Tm 4d of the sample, and performed baseline calibration before use. [24,53,54] The injectability of the glue was carried out with needles. The viscoelastic properties of the hydrogel samples were monitored by a rheological measurement (MCR320, Austria).…”

Versatile polyphenolic platforms in regulating cell biology

“…198 Moreover, our group has constructed various polyphenols-based platforms (e.g., coating and hydrogel) via the covalent interaction between antibiotics and polyphenols, which could restrain bacterial growth, showing great promise for infected inflammatory tissue therapy. 62,232,233 The fabrication approaches of different polyphenolic platforms have been summarized in Table 2.…”