Layer-by-layer self-assembly, controllable disintegration of polycarboxybetaine multilayers and preparation of free-standing films at physiological conditions

Construction and deconstruction of multilayer films containing polycarboxybetaine: Effect of pH and ionic strength

“…101 nm per bilayer, which made it possible to construct the micrometerthick multilayer film rapidly. This rapid growth of the film thickness was attributed to the large size of PEC particles in the dipping solution [34,47,48]. Fig.…”

“…Poly(4-vinylpyridiniomethanecarboxylate) was synthesized by utilizing the method reported previously [34][35][36][37]. P4VP was dissolved in methanol and stirred with an excess of methyl bromoacetate.…”

“…Polybetaine, possessing both anionic and cationic groups in the same monomer unit, offers a good alternative for fabricating disintegrable LbL multilayer films [31][32][33][34]. The main reason is that protonated carboxylic or sulfonic acid groups of the polybetaine in multilayer films can ionize to induce the films disintegration.…”

Tunable disintegration of layer-by-layer assembly multilayer films based on hydrolytical-polybetaine at wide-range time

“…As reported in literature, the multilayer film constructed by polybetaine with polycation or polyanion could disintegrate in low salt concentration solution [18,19,25,46,47]. In our previous studies [19,25], a multilayer film of polycarboxybetaine (PCB) and poly(acrylic acid) could be disintegrated controllable in the 0.01 M NaCl solution [18,19,25].…”

“…The fast deconstruction of multilayer films has been used in preparing sacrificial and releasing template [16,13,[17][18][19][20][21], fabricating micro-patterning and micro/nano-porous surfaces [22][23][24][25]. The slow deconstruction of multilayer films was mainly applied in the controlled release and gene delivery [15,[26][27][28][29][30][31][32][33][34].…”