High-density multilayer optical disc storage was investigated by employing advanced signal processing methods such as adaptive equalization and adaptive partial-response maximum-likelihood (PRML) detection. Preliminary experiments, recording on single-layer and dual-layer Blu-ray discs (BD), indicate storage capability of 33.3 GB/layer with adaptive 5-tap PRML. A new signal qualification method, sequenced amplitude margin quasi-error estimation (SAMQES), was introduced for high-density multilayer recording, and possibility toward a total storage capacity of 200 GB was examined by using a six-layer BD-Recordable disc. Despite coherent interlayer crosstalk and lower signal-to-noise ratio, SAMQES showed moderate increase from those in single-layer recording.