Layered double hydroxide induced advancement in joint prosthesis using bone cement: the effect of metal substitution

Kapusetti, Govinda; Mishra, Raghvendra; Srivastava, Swati; Misra, Nira; Singh, Vakil; Roy, Partha; Singh, Santosh Kumar; Chakraborty, Chanchal; Malik, Sudip; Maiti, Pralay

doi:10.1039/c3tb00004d

Cited by 25 publications

(26 citation statements)

References 58 publications

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“…The UV–Visible spectra of BC and ABC was recorded in the wavelength range of 200–500 nm and presented the spectrograms in Figure a. BC typically possesses the chromophoric ester group, amenable to n → π* and π → π* transitions and appear the excitations at 280 and 238 nm, respectively, which originated from the unsaturated bonds mainly (>CO; Kapusetti et al, ). ABC has shown blue/hypsochromic shift as compared to BC, due to electron‐rich moieties of methionine, it consists of the sulfur group which linked with the methyl group and carboxylic acid group.…”

Section: Resultssupporting

confidence: 54%

“…π* and π ! π* transitions and appear the excitations at 280 and 238 nm, respectively, which originated from the unsaturated bonds mainly (>C O; Kapusetti et al, 2013). ABC has shown blue/hypsochromic shift as F I G U R E 1 In silico study interactions (a-i) methionine and benzoate, (a-ii) methionine and benzoyl, (a-iii) methionine and MMA interaction, (b-i) cysteine and benzoate, (b-ii) cysteine and benzoyl, (b-iii) cysteine and MMA, and (c) binding energies of cysteine and methionine with free radicals at different temperatures.…”

Section: Molecular Interactionsmentioning

confidence: 99%

“…However, the BC poses some significant limitations such as high exothermic temperature (>70°C), fatigue failures, aspetic loosening, and predominant residual free radicals toxicity, which are generated during the in situ polymerization. (He et al, ; Jaiswal et al, ; Kapusetti et al, ; Lewis & Ed, ; Lopez‐Heredia et al, ; Marrs, Andrews, Rantell, & Pienkowski, ; Misra, Kapusetti, Jaiswal, & Maiti, ; Nussbaum, Gailloud, & Murphy, ; Vaishya, Chauhan, & Vaish, ) The exothermic polymerization of BC is processed by radical‐initiated chain growth reactions (He et al, ). During polymerization, the DMPT breaks down and interacts with BPO to form phenyl radical and attacks the double bond of the MMA monomer and leads further polymerization process (Jaiswal et al, ; Lewis & Ed, ; Nussbaum et al, ).…”

Section: Introductionmentioning

confidence: 99%

“…Benzoyl and benzoate are the free radicals generated in the above reaction from BPO and DMPT, respectively (Misra et al, 2011). It is well recognized that the presence of residual free radical followed by the in situ polymerization is the main culprits for significant toxicity effects (Graham, Pruitt, Ries, & Gundiah, 2000;Kapusetti et al, 2013;Lopez-Heredia et al, 2012;Marrs et al, 2006). The free radicals induced oxidative stress is associated with chronic diseases such as cancer, coronary heart disease (CHD), and osteoporosis (Nimse & Pal, 2015;Revie, Wallace, & Orr, 1994).…”

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confidence: 99%

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Detoxification of poly(methyl methacrylate) bone cement by natural antioxidant intervention

Choppadandi

Kapusetti

2019

J Biomedical Materials Res

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Poly(methyl methacrylate) (PMMA) bone cement is the most widely used grouting material in the joint arthroplasties and vertebroplasties. The present investigation has been carried out to scavenge the radicals and monomer by addition of an antioxidant to minimize the toxicity of bone cement (BC). The in silico studies were employed to determine the potent natural antioxidant at physiological conditions. The antioxidant methionine demonstrated a strong binding affinity with free radicals and methyl methacrylate (MMA) monomer than cysteine. The designated amount of methionine was optimized by various assay methods and >2% methionine shows strong scavenging capacity in BC. Moreover, the antioxidant‐loaded BC (ABC) demonstrated similar handling, physicochemical and mechanical properties to pristine bone cement. Significantly, the developed formulation shows superior biological characteristics such as cell proliferation (2 ± 1 BC and 6 ± 1 ABC), adhesion (0.32 ± 0.02 BC and 0.54 ± 0.01 ABC), and cell viability (81 ± 2% BC and 93 ± 1% ABC) toward human osteoblast‐like cells (MG‐63). Therefore, the novel antioxidant bone cement is a potential candidate for various orthopedic applications to eliminate the adverse effects, related to residual toxic radical and monomer in bone cement.

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Section: Resultssupporting

confidence: 54%

Section: Molecular Interactionsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 99%

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Detoxification of poly(methyl methacrylate) bone cement by natural antioxidant intervention

Choppadandi

Kapusetti

2019

J Biomedical Materials Res

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“…Studies focusing on the action of LDHs on bone cells are very scarce . Hence, we investigated the effect of LDH materials on preosteoblast metabolism, mainly addressing their possibility to modulate the expression of osteogenic differentiation genes.…”

Section: Introductionmentioning

confidence: 64%

Mg–Al and Zn–Al Layered Double Hydroxides Promote Dynamic Expression of Marker Genes in Osteogenic Differentiation by Modulating Mitogen‐Activated Protein Kinases

Kang

Fernandes

Silva

et al. 2017

Adv Healthcare Materials

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The effect of LDH samples comprised of chloride anions intercalated between positive layers of magnesium/aluminum (Mg-Al LDH) or zinc/aluminum (Zn-Al LDH) chemical composition on pre-osteoblast performance is investigated. Non-cytotoxic concentrations of both LDHs modulated pre-osteoblast adhesion by triggering cytoskeleton rearrangement dependent on recruiting of Cofilin, which is modulated by the inhibition of the Protein Phosphatase 2A (PP2A), culminating in osteoblast differentiation with a significant increase of osteogenic marker genes. The alkaline phosphatase (ALP) and bone sialoprotein (BSP) are significantly up-modulated by both LDHs; however, Mg-Al LDH nanomaterial promoted even more significance than both experimental controls, while the phosphorylations of mitogen-activated protein kinase (MAPKs)- extracellular signal-regulated kinases (ERK) and c-Jun N-terminal kinase (JNK) significantly increased. MAPK signaling is necessary to activate Runt-related transcription factor 2 (RUNX2) gene. Concomitantly, it is also investigated whether challenged osteoblasts are able to modulate osteoclastogenesis by investigating both osteoprotegerin (OPG) and Receptor activator of nuclear factor kappa-ligand (RANKL) in this model; a dynamic reprogramming of both these genes is found, suggesting LDHs in modulating osteoclastogenesis. These results suggest that LDHs interfere in bone remodeling, and they can be considered as nanomaterials in graft-based bone healing or drug-delivery materials for bone disorders.

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Layered Double Hydroxides: A Novel Promising 2D Nanomaterial for Bone Diseases Treatment

Bian

Cai

et al. 2023

Advanced Science

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Bone diseases including bone defects, bone infections, osteoarthritis, and bone tumors seriously affect life quality of the patient and bring serious economic burdens to social health management, for which the current clinical treatments bear dissatisfactory therapeutic effects. Biomaterial‐based strategies have been widely applied in the treatment of orthopedic diseases but are still plagued by deficient bioreactivity. With the development of nanotechnology, layered double hydroxides (LDHs) with adjustable metal ion composition and alterable interlayer structure possessing charming physicochemical characteristics, versatile bioactive properties, and excellent drug loading and delivery capabilities arise widespread attention and have achieved considerable achievements for bone disease treatment in the last decade. However, to the authors' best knowledge, no review has comprehensively summarized the advances of LDHs in treating bone disease so far. Herein, the advantages of LDHs for orthopedic disorders treatment are outlined and the corresponding state‐of‐the‐art achievements are summarized for the first time. The potential of LDHs‐based nanocomposites for extended therapeutics for bone diseases is highlighted and perspectives for LDHs‐based scaffold design are proposed for facilitated clinical translation.

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Layered double hydroxide induced advancement in joint prosthesis using bone cement: the effect of metal substitution

Cited by 25 publications

References 58 publications

Detoxification of poly(methyl methacrylate) bone cement by natural antioxidant intervention

Detoxification of poly(methyl methacrylate) bone cement by natural antioxidant intervention

Mg–Al and Zn–Al Layered Double Hydroxides Promote Dynamic Expression of Marker Genes in Osteogenic Differentiation by Modulating Mitogen‐Activated Protein Kinases

Layered Double Hydroxides: A Novel Promising 2D Nanomaterial for Bone Diseases Treatment

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