Layered double hydroxide nanoparticles for biomedical applications: Current status and recent prospects

Multi-laminated metal hydroxide nanocontainers for oral-specific delivery for bioavailability improvement and treatment of inflammatory paw edema in mice

“…LDHs are well known for their targeting ability [67][68][69] and easy particle functionalization [70]. In addition, LDHs enhance photo stability as well as solubility [71] and improve the contrast efficacy of imaging agents [39,40,72]. The first report of Eudragit coated layered matrices as a shell around a fenbufen loaded LDH core was reported by Li et al [73].…”

“…where M II represents a divalent metal cation (Mg 2+ ), M III represents a trivalent metal cation (Al 3+ ) and A m-denotes the interlayer anions (NO 3 -) [31]. The unique ion-layer charge interaction in the supermolecular structure allow for the intercalation of various anionic molecules and fluorescent dyes via ion-exchange to construct a variety of LDH nanohybrids that have desirable properties for various uses, such as drug delivery [32][33][34][35][36], vaccination [37], targeting [38], and imaging [39,40]. LDHs have been used as a carrier for various negatively charged bio-moieties, for instance siRNA [31,[41][42][43][44][45][46], antibodies [2], carbohydrates [47], amino acids [48], enzymes [49], antimicrobial drugs [50,51], anti-inflammatory drugs [52], and anticancer drugs [33,36,[53][54][55][56][57][58].…”

“…LDHs have been used as a carrier for various negatively charged bio-moieties, for instance siRNA [31,[41][42][43][44][45][46], antibodies [2], carbohydrates [47], amino acids [48], enzymes [49], antimicrobial drugs [50,51], anti-inflammatory drugs [52], and anticancer drugs [33,36,[53][54][55][56][57][58]. In addition, LDHs possess beneficial properties, such as high surface area, high dispersity, high anionic drug loading ability and good biocompatibility [59,60] with controlled drug release [26,36,40,55,[61][62][63][64][65][66]. LDHs are well known for their targeting ability [67][68][69] and easy particle functionalization [70].…”

Functionalization of Surfaces in Layered Double Hydroxides and Hydroxide Salt Nanoparticles

“…Advanced applications have been found in the biomedical field as nanovehicles for delivery of ibuprofen, enalaprilate [17], 5-fluoracil, methotrexate [18], DNA segments [19], cosmeceuticals [20], as well as nanoparticles for diagnoses through fluorecent or magnetic analyses [21][22][23].…”

Systemic toxicity induced by aggregated layered double hydroxide nanoparticles

“…5,13,14 Several researchers have conjugated a variety of drugs (including the anti-tuberculosis agent paraaminosalicylic acid; 15 glucocorticoid drug betamethasone sodium phosphate; 16 antihypertensive prodrug perindopril erbumine; 17 anticancer moieties such as chlorogenic acid, 18 10-hydroxycamptothecin, 19 and protocatechuic acid; 20 photosensitizer indole-3-acetic acid; 21 and the poor water-soluble drug ibuprofen, 22 as well as nucleic acids 23 and enzymes 24 ) into the interspaces of LDH nanoparticles and successfully delivered them into cells.…”