2023
DOI: 10.21203/rs.3.rs-2637837/v1
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LBP resists hepatic oxidative stress by regulating LD homeostasis

Abstract: Lipopolysaccharide-binding protein (LBP), an acute-phase protein, is expressed in inflammatory response and stress1,2, but its intracellular function is still unclear. Here, we uncover the profound paradigm of LBP as an antioxidant by coupling lipid droplet (LD) metabolism and redox signal, which protects hepatocytes from lipid peroxidation. LBP is upregulated and identified in LDs of hepatocytes after 24h fasting. Hepatic knock-in of LBP causes severe steatosis and LD accumulation on a high-fat diet. We showe… Show more

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