LC-MS/MS based metabolite profiling and lipase enzyme inhibitory activity of Kaempferia angustifolia Rosc. with different extracting solvents

Rafi, Mohamad; Karomah, Alfi Hudatul; Septaningsih, Dewi Anggraini; Trivadila,; Rahminiwati, Min; Putri, Sastia Prama; Iswantini, Dyah

doi:10.1016/j.arabjc.2022.104232

Cited by 12 publications

(4 citation statements)

References 22 publications

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“…The major mass fragment detected for this peak was m / z 433.1089, which is consistent with the loss of a pentose group. Based on this and data from the previously published literature, compound 2 was tentatively identified as Apigenin 7- O -(β- d -apiosyl-(1 → 2)-β- d -glucoside), commonly known as apiin. − …”

Section: Resultsmentioning

confidence: 99%

Chemical Constituents of Parsley (Petroselinum crispum) Leaf Extract and Its Potential in Mitigating the Effects of Viral Infections

Lee,

Liu,

et al. 2023

ACS Food Sci. Technol.

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Section: Resultsmentioning

confidence: 99%

Chemical Constituents of Parsley (Petroselinum crispum) Leaf Extract and Its Potential in Mitigating the Effects of Viral Infections

Lee,

Liu,

et al. 2023

ACS Food Sci. Technol.

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“…Distilled water, 50% ethanol and pure ethanol were the extraction solvents and the application of each was repeated five times. The filtrate was collected, concentrated using a rotary evaporator at 40 ºC and the extract was then stored in a freezer at -80 ºC [22].…”

Section: Methodsmentioning

confidence: 99%

Metabolite Profiling and Inhibitory Effects of Nitric Oxide on Andrographis paniculata Burm. F Nees Extract using Different Solvents as a Potential Candidate in COVID-19 Therapy

Lukito,

Iswantini,

Antariksa

et al. 2024

ajc

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Andrographis paniculata Burm. F Nees used to treat COVID-19 in several Asian countries because it has metabolites with pharmacological activity that may decrease the pathogenesis features of COVID-19. The extraction solvent significantly affected the composition and concentration of the metabolites. Therefore, the inhibitory effects of nitric oxide of A. paniculata extract based on differences in extraction solvent concentrations were investigare and also identified its metabolite profile. The leaves of A. paniculata were extracted with three different solvents like water solvent, 50% ethanol and pure ethanol. Nitrite oxide (NO) inhibitory activity on LPS-activated RAW 264.7 macrophage cells was used to evaluate the anti-inflammatory activity of the extract, the identification of metabolite profile using LC-MS/MS. Extract pure ethanol had the highest inhibition potential against NO at 91.02%, whereas water and 50% ethanol solvents had inhibitory potentials of 21.35% and -8.13%, respectively. The metabolites 14-deoxyandrographoside and 14-deoxy-17-hydroxyandrographolid were only identified in the pure ethanol extract. This study shows that differences in solvent concentrations play an essential role in enhancing the pharmacological potential of A. paniculata as an anti-inflammatory candidate for COVID-19 treatment.

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“…LC-MS/MS is an advanced and sophisticated technique that can be used to pro le metabolites in a sample due to its high sensitivity, selectivity and high resolution. Additionally, this technique can reduce the complexity of metabolite samples by enabling the identi cation, measurement and separation of metabolites before their detection 13 .…”

Section: Introductionmentioning

confidence: 99%

Potential anti-HIV and antitrypanosomal components revealed in Sorindeia nitidula via LC-ESI-QTOF-MS/MS and molecular docking

Ebede,

Okoro,

Mbing

et al. 2024

Preprint

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Sorindeia nitidula is used by traditional practitioners to treat influenza illnesses with cephalgia and febrile aches. However, the potential active ingredients for its remarkable antioxidant, anti-HIV and antitrypanosomal activities remain unexplored. The present study aims to evaluate the antioxidant, anti-HIV and antitrypanosomal activities of the ethyl acetate extract of S. nitidula (SN) in order to screen out the bioactive compounds and to analyze their possible mechanisms of action. Overall, 21 phenolic compounds were annotated, by using the MS and MS/MS information provided by the QTOF-MS. In vitro assays on the extract revealed potent antioxidant (IC50 = 0.0129 mg/mL), anti-HIV (IC50 = 1.736 mg/mL), antitrypanosomal (IC50 = 1.040 µM) activities. Furthermore, SN did not present cytotoxic effect on HeLa cancer cell lines (IC50 = 0.045 µM). Molecular docking revealed that the potential ligands exhibited strong binding ability and inhibitory activities on trypanosome. The integrated strategy based on LC-ESI-QTOF-MS/MS and molecular docking provided a powerful tool and a multidimensional perspective for further exploration of active ingredients in S. nitidula responsible for the antioxidant, anti-HIV and antitrypanosomal activities.

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LC-MS/MS based metabolite profiling and lipase enzyme inhibitory activity of Kaempferia angustifolia Rosc. with different extracting solvents

Cited by 12 publications

References 22 publications

Chemical Constituents of Parsley (Petroselinum crispum) Leaf Extract and Its Potential in Mitigating the Effects of Viral Infections

Chemical Constituents of Parsley (Petroselinum crispum) Leaf Extract and Its Potential in Mitigating the Effects of Viral Infections

Metabolite Profiling and Inhibitory Effects of Nitric Oxide on Andrographis paniculata Burm. F Nees Extract using Different Solvents as a Potential Candidate in COVID-19 Therapy

Potential anti-HIV and antitrypanosomal components revealed in Sorindeia nitidula via LC-ESI-QTOF-MS/MS and molecular docking

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