LDH-linked immunoglobulin g in ulcerative colitis.

Abstract

LDH isoenzymes in sera from 42 patients with ulcerative colitis were analyzed by means of electrophoretic technique. The abnormal LDH isoenzyme patterns were observed in 4 patients out of them. In the present study, LDH-linked immunoglobulins (Ig) in these 4 patients were examined by immunoelectrophoresis, immunodiffusion and the precipitation method. Then LDH-linked Ig with partial isotypic specifities were identified, i. e., one was LDH-linked IgG (kappa) and the others were LDH-linked IgG (lambda). ALP-linked Ig in ulcerative colitis was identified as IgG in Kano's report. Therefore, the relationship between the isotypic specif ity of LDH-linked IgG and ulcerative colitis was speculated.