2010
DOI: 10.1139/y10-048
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Le kétoconazole antagonise les effets immuno-gonadotropes au test de la nage forcée chez le rat mâle Wistar

Abstract: Disturbances in the activity of the corticotropic axis and immune system have been widely reported to be linked to the development of depression. The aim of this study was to explore the effects of ketoconazole, an imidazole derivative that inhibits gonadal and adrenal steroidogenesis, on changes in the total leukocyte count and the percentages of leukocyte subpopulations during the Porsolt forced swimming test (commonly used to measure the efficiency of antidepressants) in rats. Catheters were implanted in th… Show more

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Cited by 3 publications
(3 citation statements)
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“…During the test of FST, antidepressants, producing a predominant noradrenergic or dopaminergic elevation, reduce immobility by increasing climbing time [29]. On the other hand, those which activate 5-hydroxytryptamine (5HT) instead reduce immobility by the increase in swimming [30][31][32]. Connor et al (1997) [17] were able to characterize corticotropin and immune responses and examine neurotransmitter levels in five regions of the brain at time intervals of 5, 30, 60, 90, and 120 min following forced swimming.…”
Section: Discussionmentioning
confidence: 99%
“…During the test of FST, antidepressants, producing a predominant noradrenergic or dopaminergic elevation, reduce immobility by increasing climbing time [29]. On the other hand, those which activate 5-hydroxytryptamine (5HT) instead reduce immobility by the increase in swimming [30][31][32]. Connor et al (1997) [17] were able to characterize corticotropin and immune responses and examine neurotransmitter levels in five regions of the brain at time intervals of 5, 30, 60, 90, and 120 min following forced swimming.…”
Section: Discussionmentioning
confidence: 99%
“…EPM consists of two open arms (50X10cm) opposite each other, crossed by two closed arms (50X10X 40cm), the device is placed 50cm above the ground (Zhang et al 2020).In this test, the animal is placed in the center of the maze facing a closed arm and left to explore for 5 min, its behavior is then observed to measure the time spent in the open and closed arms as well as the number of entries of each ratin each of these arms (Jurgenson et al 2010).Rats that have remained confined in closed arms are described as being anxious (Frih et al 2010).…”
Section: Elevated Plus Maze (Epm) Testmentioning
confidence: 99%
“…The FST is a behavioral model consisting in inducing a state of despair in rats and mice (Frih et al 2010) in which the animals are placed individually for 5 minutes in a cylinder in glass (54 cm high X 34 cm X 60 cm), two-thirds filled with water at 26 ± 1 ° C (Porsolt et al 1978).The behavior of the animal in the device is filmed using a video camera; the time of immobility is measured.In this case, immobility is interpreted as a reflection of "behavioral hopelessness" where the duration of immobility is indicative of the degree of hopelessness in the animal (Taibi et al 2020).…”
Section: Forced Swimming Test (Fst)mentioning
confidence: 99%