Le rôle des anesthésiologistes dans la réduction des préjudices liés aux opioïdes

Opioid-free anesthesia: the next frontier in surgical patient safety

“…Mu receptor agonism is associated with significant perioperative side effects, including respiratory depression, postoperative nausea/vomiting, constipation, and altered immunomodulatory signaling pathways [ 7 ]. Traditionally, the unfavorable side effect profile of morphine-like opioids has been tolerated as a necessary “collateral damage” of general anesthesia, and the management of these side effects has represented a routine part of perioperative care [ 8 ]. These traditional standards of opioid-based pain control during surgery and postoperative care have only recently been challenged in response to the recognition of the “iatrogenic” root cause of the widespread opioid addiction epidemic in the twenty-first century [ 2 ].…”