Le rôle du fenugrec dans la survenue d’anomalie de fermeture du tube neural : un signal d’alerte depuis le Maroc

Seddiki, A. Es; Messaouidi, S.; Amrani, R.

doi:10.1007/s10298-017-1128-x

Cited by 6 publications

(7 citation statements)

References 18 publications

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“…In Morocco, this plant is consumed to treat several diseases and its seeds are used for pregnancy-related ailments such as vomiting as well as to stimulate appetite [ 40 ]. In their analysis of studies on the clinical association between fenugreek consumption and the occurrence of NTDs, A. Es Seddiki et al reached the conclusion that this plant represents a major risk factor and had detrimental fetotoxic and teratogenic effects on the fetus [ 41 ].…”

Section: Discussionmentioning

confidence: 99%

Incidence of neural tube defects and their risk factors within a cohort of Moroccan newborn infants

et al. 2021

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Background Neural tube defects (NTDs) are a group of birth defects that result from a partial or complete failure of the neural tube to close during embryogenesis. Their prevalence varies between 0.5 to 2 per 1000 births in countries without folic acid supplementation. The aim of our study is to assess the NTDs incidence and describe the risk factors within Moroccan newborn infants. Method This is a descriptive study over a period of 5 and a half years including all births at “Les Orangers” Maternity and Reproductive Health Hospital of Rabat with notification of NTD cases, whether isolated or combined with other anomalies. Data were reported on pre-established sheets and on the teratovigilance registry. Statistical analysis was performed with SPSS version 18 statistical software. Results During the study period, 43,923 births were recorded including 44 cases of neural tube defects, an incidence rate of 1 per 1000 births, with a female predominance; sex ratio = 0.8. These defects included anencephaly (50%), spina bifida (38.6%) and encephalocele (11.4%). The risk factors detected during this study include consanguinity (34%), consumption of fenugreek or other plants (36%), diabetes (4.5%) and medication (2.2%). A family history of malformation was reported in 6.8% of cases and among siblings in 4.5% of cases. The average maternal age was 30.38 ± 6.88 and the average gestational age was 36.80 ± 5.11. A quarter of mothers did not benefit from any medical monitoring during pregnancy while 59% did not take folic acid supplementation during the first trimester of pregnancy and none of them took B9 vitamin during the periconceptional period. The antenatal diagnosis was performed in 63% of cases. The mortality rate was 3.8 per 10,000 and 16% of cases evolved positively. Conclusion NTDs require high intensity and multidisciplinary care which stresses the importance, in our context, of strengthening and optimizing acid folic supplementation strategies during the periconceptional period.

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Section: Discussionmentioning

confidence: 99%

Incidence of neural tube defects and their risk factors within a cohort of Moroccan newborn infants

et al. 2021

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“…After Antananarivo, Mahajanga is the second most frequent source of spinal dysraphism, because in the western regions of the country, pregnant women tend to take fegnegrec, which increases the risk of developing a neural tube defect according to Moroccan studies [3].…”

Section: Discussionmentioning

confidence: 99%

The Reality of the Management of Spinal Dysraphism in a Country in a Precarious Situation: A Retrospective Study

Andrianaivo,

Rakotondraibe,

Synese

et al. 2024

CLINICMED

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Background: To report the epidemiological, therapeutic and evolutionary aspects of spinal dysraphism, with emphasis on the difficulties encountered during management in Madagascar. Methods: This is a retrospective, descriptive, multicenter study in the 7 neurosurgical centers of Madagascar over 5 years on children operated on for spinal dysraphism. Results: We collected 50 cases over 5 years. The mean age was 16.95 ± 33.94 months. Girls predominated (sex ratio = 0.85). The absence of folic acid supplementation in the mother was found in 62%. In all cases, the diagnosis was made in the postnatal period. Myelomeningocele is the most frequent form. Hydrocephalus was found in 20% of cases, orthopaedic malformation in 20%, and Chiari type II malformation in 2%. The dysraphism was localized at the lumbar level in 50% of cases. A spinal CT scan was performed in 62% of cases and transfontanellar ultrasound in 22% of cases. No magnetic resonance imaging of the brain or spinal cord was performed. A ventriculoperitoneal shunt was performed in 8% of cases. Postoperative hydrocephalus was 4%and mortality was 1% due to meningitis. The average follow-up time was 3 months with an extreme of 3 months to 3 years. Conclusion: In spite of the difficulties in the management of these children and the technical platform available in the country, they are operated correctly and the hospital mortality is low.

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“…It is very popular with women in the Mediterranean, and for a few years in Senegal. In Morocco, it has been mentioned anecdotally in the genesis of prosencephalic induction abnormalities and more significantly in neural tube malformations [12]. Inbreeding, as a risk factor, has also been reported.…”

Section: Risk Factorsmentioning

confidence: 99%

The Cyclopie: About an Observation and Review of Literature

JMM,

GK,

et al. 2024

JOJO

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Cyclops are the most severe form of holoprosencephaly. It is a rare polygenetic malformation that occurs during early embryonic development.It is a single eye, or by extension, two eyes, contained in the same median orbit. We report a case of cyclopy at the Aristide Le Dantec National University Hospital. It was premature of 35 SA + 05 days, born of a pregnancy complicated by eclampsia, without pathological history in the parents. A prenatal ultrasound had objectified a severe hydro-amnios with a microcephaly. The ophthalmological examination showed a single median orbital cavity containing two different sized eyeballs. The general examination objectified a microcephaly, an arhinia and an abscess of the right foot. The orbito-cerebral CT showed a major cerebral malformation with microcrania type and a cyclopia. The child died after 27 days of ectopic life from respiratory distress. Cyclopia is a non-viable malformation whose prenatal diagnosis is based on the realization of an obstetric ultrasound from 12eSA. An etiological assessment is essential, it makes it possible to look for environmental and genetic risk factors.

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Le rôle du fenugrec dans la survenue d’anomalie de fermeture du tube neural : un signal d’alerte depuis le Maroc

Cited by 6 publications

References 18 publications

Incidence of neural tube defects and their risk factors within a cohort of Moroccan newborn infants

Incidence of neural tube defects and their risk factors within a cohort of Moroccan newborn infants

The Reality of the Management of Spinal Dysraphism in a Country in a Precarious Situation: A Retrospective Study

The Cyclopie: About an Observation and Review of Literature

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