Le Syndrome et la cellule de Sézary

Abstract

The author gives a summary of the recent researches concerning Sézary’s syndrome.

Treatment of patients with advanced mycosis fungoides and Sézary syndrome with alemtuzumab

“…Over time, the disease can evolve through several clinical stages, usually beginning with the presence of erythrematous skin patches and eventually progressing to ulcerative tumors and/or involvement of extracutaneous tissues (2). The presentation of Sézary syndrome (SS) is characterized by a pruritic infiltrative erythroderma accompanied by circulating CTCL (Sézary) cells (3, 4). Although early stage MF may be easily controlled with a range of topical therapies, treatment of advanced stage MF and SS remains sub‐optimal, with most patients developing either refractory disease or dying of infectious complications (2, 5).…”

Lymphocyte-epidermis interactions in malignant epidermotropic lymphomas: I. Ultrastructural aspects

“…The origin of the exocytosis is unknown and var ious hypotheses are proposed to explain this phenomenon: eithcr an antigenie modification of the epidermis or a moditication of recognition capacities of the proliferating lymphoid cells ( 13) against the epidermis.…”