Le transfert osseux vascularisé prélevé sur la face antérieure du radius dans la reconstruction des os du carpe

Mathoulin, Christophe; Gras, Mathilde; Roukos, S.

doi:10.1016/j.main.2010.09.010

Cited by 10 publications

(1 citation statement)

References 36 publications

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“…Thus, the ability to generate new bone is still a major clinical need which creates an enormous social and economic burden. Current clinical therapies such as autografts are seen as the gold standard [ 5 , 6 ], however, these procedures are highly invasive, with limited tissue availability and inducing donor site morbidity [ 7 , 8 ]. Consequently, extensive research has been conducted in the tissue engineering field to meet the rising demand for clinically relevant bone tissue.…”

Section: Introductionmentioning

confidence: 99%

The Selective Histone Deacetylase Inhibitor MI192 Enhances the Osteogenic Differentiation Efficacy of Human Dental Pulp Stromal Cells

Man

Lawlor

Jiang

et al. 2021

IJMS

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The use of human dental pulp stromal cells (hDPSCs) has gained increasing attention as an alternative stem cell source for bone tissue engineering. The modification of the cells’ epigenetics has been found to play an important role in regulating differentiation, with the inhibition of histone deacetylases 3 (HDAC3) being linked to increased osteogenic differentiation. This study aimed to induce epigenetic reprogramming using the HDAC2 and 3 selective inhibitor, MI192 to promote hDPSCs osteogenic capacity for bone regeneration. MI192 treatment caused a time–dose-dependent change in hDPSC morphology and reduction in viability. Additionally, MI192 successfully augmented hDPSC epigenetic functionality, which resulted in increased histone acetylation and cell cycle arrest at the G2/M phase. MI192 pre-treatment exhibited a dose-dependent effect on hDPSCs alkaline phosphatase activity. Quantitative PCR and In-Cell Western further demonstrated that MI192 pre-treatment significantly upregulated hDPSCs osteoblast-related gene and protein expression (alkaline phosphatase, bone morphogenic protein 2, type I collagen and osteocalcin) during osteogenic differentiation. Importantly, MI192 pre-treatment significantly increased hDPSCs extracellular matrix collagen production and mineralisation. As such, for the first time, our findings show that epigenetic reprogramming with the HDAC2 and 3 selective inhibitor MI192 accelerates the osteogenic differentiation of hDPSCs, demonstrating the considerable utility of this MSCs engineering approach for bone augmentation strategies.

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Section: Introductionmentioning

confidence: 99%

The Selective Histone Deacetylase Inhibitor MI192 Enhances the Osteogenic Differentiation Efficacy of Human Dental Pulp Stromal Cells

Man

Lawlor

Jiang

et al. 2021

IJMS

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Prognostic factors in the treatment of carpal scaphoid non-unions

Schuind

Moungondo

Kazzi

2016

Eur J Orthop Surg Traumatol

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In this literature review, the authors analyse the prognostic factors in the curative treatment of scaphoid non-unions. The main negative prognostic factors are smoking, the time elapsed since the fracture, and avascular necrosis of the proximal fragment. If the latter is present, the revascularization by a pedicle or microsurgical bone autograft is probably the treatment of choice. In non-unions without evidence of osteonecrosis, vascularized bone grafts are probably not superior to conventional bone grafts, which can presently be performed under arthroscopic control, with minimal morbidity.

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Resultados del tratamiento de seudoartrosis de escafoides con injerto microvascularizado de arteria 1,2 intercompartimental suprarretinacular y osteosíntesis

Álvarez-Castro

Río

Diez-Romero

et al. 2014

Revista Española de Cirugía Ortopédica y Traumatología

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Le transfert osseux vascularisé prélevé sur la face antérieure du radius dans la reconstruction des os du carpe

Cited by 10 publications

References 36 publications

The Selective Histone Deacetylase Inhibitor MI192 Enhances the Osteogenic Differentiation Efficacy of Human Dental Pulp Stromal Cells

The Selective Histone Deacetylase Inhibitor MI192 Enhances the Osteogenic Differentiation Efficacy of Human Dental Pulp Stromal Cells

Prognostic factors in the treatment of carpal scaphoid non-unions

Resultados del tratamiento de seudoartrosis de escafoides con injerto microvascularizado de arteria 1,2 intercompartimental suprarretinacular y osteosíntesis

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