With the global land use/land cover (LULC) and climate change, the ecological resilience (ER) in typical Karst areas has become the focus of attention. Its future development trend and its spatial response to natural and anthropogenic factors are crucial for understanding the changes of ecologically fragile areas to human behavior. However, there is still a lack of relevant quantitative research. The study systematically analyzed the characteristics of LULC changes in Southwest China with typical Karst over the past 20 years. Drawing on the landscape ecology research paradigm, a potential-elasticity-stability ER assessment model was constructed. Revealing the characteristics and heterogeneity of the spatial distribution, annual evolution, and development trend of ER in the past and under different scenarios of shared socioeconomic pathways and representative concentration pathways (SSP-RCP) in the future. In addition, the spatial econometric model was utilized to reveal the spatial effect response mechanism of ER, and adaptive development strategies were proposed to promote the sustainable development of Southwest China. The study found that : (1) In the past 20 years, the LULC in Southwest China showed an accelerated change trend, the ER decreased declined in general, and there was significant spatial heterogeneity, showing the spatial distribution pattern of “west is larger than east, south is larger than north, and reduction in the west was slower than that in the east.” (2) Under the same SSP scenario, with the increase of RCP emission concentration, the area of the lowest-resilience increased significantly, and the area of the highest-resilience decreased. (3) The woodland was the largest contributor to ER per unit area in the Southwest China, and grassland was the main LULC type, which had a prominent impact on the ER of the study area. (4) The average precipitation and the normalized difference vegetation index (NDVI) were significant natural drivers of ER in the study area, and the economic growth, innovation, and optimization of industrial structure contributed to the ER of Southwest China. Overall, the integration of quantitative assessment and multi-scenario-based modeling not only provides new perspectives for understanding the pattern of change and response mechanisms, but also provides valuable references for other typical Karst regions around the world to achieve sustainable development.
