Lead exposure induces neuronal apoptosis via NFκB p65/RBBP4/Survivin signaling pathway

Chen, Hui; Zhang, Wei; Luo, Song; Li, Yanshu; Zhu, Qian; Xia, Yongli; Tan, Hong; Bian, Ying; Li, Yaobing; Ma, Jianmin; Chen, Wei; Luo, Xietian; Zhu, Gaochun

doi:10.1016/j.tox.2023.153654

Cited by 5 publications

(1 citation statement)

References 42 publications

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“…In the realm of targeted therapy research focused on RBBP4/7, these proteins have demonstrated significant potential in the treatment of various diseases, particularly in modulating therapeutic outcomes. For example, increased expression of RBBP4 has been linked to mitigating lead-induced neuronal apoptosis, suggesting a potential role in alleviating lead poisoning and related neurological disorders ( 178 ). Additionally, the interaction of RBBP4 with the efficacy of multiple drugs has been extensively studied, including its role in enhancing the sensitivity of GBM cells to TMZ ( 56 , 95 ), suppression of LC cell malignancy via ropivacaine by downregulating RBBP4 ( 179 ), and the identification of the circ-0110498/miR-1287-5p/RBBP4 axis as a novel target for overcoming cisplatin resistance in NSCLC ( 85 ).…”

Section: Rbbp4/7 As Potential Targets For Human Disease Treatmentmentioning

confidence: 99%

Interpreting the molecular mechanisms of RBBP4/7 and their roles in human diseases (Review)

Zhan,

Yin,

et al. 2024

Int J Mol Med

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Histone chaperones serve a pivotal role in maintaining human physiological processes. They interact with histones in a stable manner, ensuring the accurate and efficient execution of DNA replication, repair and transcription. Retinoblastoma binding protein (RBBP)4 and RBBP7 represent a crucial pair of histone chaperones, which not only govern the molecular behavior of histones H3 and H4, but also participate in the functions of several protein complexes, such as polycomb repressive complex 2 and nucleosome remodeling and deacetylase, thereby regulating the cell cycle, histone modifications, DNA damage and cell fate. A strong association has been indicated between RBBP4/7 and some major human diseases, such as cancer, age-related memory loss and infectious diseases. The present review assesses the molecular mechanisms of RBBP4/7 in regulating cellular biological processes, and focuses on the variations in RBBP4/7 expression and their potential mechanisms in various human diseases, thus providing new insights for their diagnosis and treatment.

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