Lead phytomolecules for gastroprotective drug development

Murti, Yogesh; Agrawal, Krishn Kumar; Semwal, Bhupesh Chander; Singh, Sonia

doi:10.1007/s13596-022-00633-7

Cited by 7 publications

(3 citation statements)

References 65 publications

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“…The major components of ginger extract are gingerols and shogaols, including 6-shogaol, 8-shogaol, 10-shogaol, 10-gingerol, 8-gingerol, and 6-gingerol ( Mao et al, 2019 ). Other phytochemical constituents found in ginger are zingerone ( Schadich et al, 2016 ; Ji et al, 2017 ; Murti et al, 2022 ), 6-dehydrogingerdione, quercetin, gingerenone-A, zingerone, geranial, and eugenol ( Singh et al, 2008 ; Mao et al, 2019 ). Fresh organically grown ginger analyzed by GC-MS was found to contain shogaols, gingerols, gingerdiols, 3-dihydroshogaols, acetyl derivatives of gingerols, methyl ether derivatives of shogaols, mono- and diacetyl derivatives of gingerdiols, diarylheptanoids, 1-dehydrogingerdiones, paradols, and dihydroparadols ( Jolad et al, 2004 ).…”

Section: Phytochemistrymentioning

confidence: 99%

“…In another study, the rhizome oil was found to contain 30 compounds where zerumbone, α-caryophyllene, and 1,5,5,8-tetramethyl-12-oxabicyclo[9.1.0]dodeca-3,7-diene were the main components ( Bhuiyan et al, 2008 ). Zerumbone was identified as the major compound contributing to the gastroprotective activity of Z. zerumbet ( Murti et al, 2022 ).…”

Section: Phytochemistrymentioning

confidence: 99%

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Immunomodulatory effects and mechanisms of the extracts and secondary compounds of Zingiber and Alpinia species: a review

et al. 2023

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Zingiber and Alpinia species (family: Zingiberaceae) are popularly used in food as spices and flavoring agents and in ethnomedicine to heal numerous diseases, including immune-related disorders. However, their ethnomedicinal uses have not been sufficiently supported by scientific investigations. Numerous studies on the modulating effects of plants and their bioactive compounds on the different steps of the immune system have been documented. This review aimed to highlight up-to-date research findings and critically analyze the modulatory effects and mechanisms of the extracts and secondary compounds of several Zingiber and Alpinia species, namely, Zingiber officinale Roscoe, Z. cassumunar Roxb., Z. zerumbet (L.) Roscoe ex Sm., Alpinia galanga Linn., A. conchigera Griff, A. katsumadai Hayata, A. oxyphylla Miq., A. officinarum Hance, A. zerumbet (Pers.) Burtt. et Smith, and A. purpurata (Viell.) K. Schum. on the immune system, particularly via the inflammation-related signaling pathways. The immunomodulating activities of the crude extracts of the plants have been reported, but the constituents contributing to the activities have mostly not been identified. Among the extracts, Z. officinale extracts were the most investigated for their in vitro, in vivo, and clinical effects on the immune system. Among the bioactive metabolites, 6-, 8-, and 10-gingerols, 6-shogaol, and zerumbone from Zingiber species and cardamomin, 1′-acetoxychavicol acetate, yakuchinone, rutin, 1,8-cineole, and lectin from Alpinia species have demonstrated strong immunomodulating effects. More experimental studies using cell and animal models of immune-related disorders are necessary to further understand the underlying mechanisms, together with elaborate preclinical pharmacokinetics, pharmacodynamics, bioavailability, and toxicity studies. Many of these extracts and secondary metabolites are potential candidates for clinical development in immunomodulating agents or functional foods to prevent and treat chronic inflammatory disorders.

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Section: Phytochemistrymentioning

confidence: 99%

Section: Phytochemistrymentioning

confidence: 99%

Immunomodulatory effects and mechanisms of the extracts and secondary compounds of Zingiber and Alpinia species: a review

et al. 2023

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“…This technology has gained massive attention in recent years in the field of oral drug delivery. Gastro-retentive dosage forms can hold drugs in the gastrointestinal region for an extended period, significantly sustaining drug retention [6,7].…”

Section: Introductionmentioning

confidence: 99%

Formulation and Evaluation of Oral Mucoadhesive Microspheres of Ofloxacin for Peptic Ulcer Use

et al. 2023

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A peptic ulcer is a disease that affects the stomach lining caused by Helicobacter pylori. The present research aimed to formulate and evaluate the mucoadhesive microsphere of ofloxacin for the effective and safe treatment of peptic ulcers. The mucoadhesive microspheres were developed using natural polymers like Guar gum, Sodium alginate, and Chitosan using the emulsification cross-linking method. A total of 8 batch formulations were prepared using 23 full factorial designs. The prepared microspheres were evaluated various parameters such as % yield, entrapment efficiency, drug release study, in vitro wash-off test, optimization was done by the design of expert which was further subjected to statistical analysis that was kinetic release mechanism, compatibility studies were performed such as FTIR and DSC. Using factorial design 23 for the maximum possible formulation, the optimized formulation was found to be F5 in terms of better release for a longer time and with better mucoadhesive properties on the use of guar gum, sodium alginate, and chitosan in ratio 1:1:2. Second-order polynomial equations were derived for absorbing responses after the application of ANOVA, after omitting the non-significant (p ≥ 0.05) coefficients. %CDR 56.10 % for an extended period of 8 h, % EE exhibited 86.25±1.16. The sustained release activity of F5 might be due to the adhesion of the polymer to the gastric mucosa for more extended periods of 71 % to 8 h. it is also favoured by the suitable particle size of the optimized formulation. The result indicated that the prepared mucoadhesive microspheres can release the ofloxacin in sustained manner and helps in the management of peptic ulcer. HIGHLIGHTS Ofloxacin loaded mucoadhesive microsphere was prepared for treatment of peptic ulcer The mucoadhesive microspheres were developed using natural polymers A total of 8 batch formulations were prepared using 23 full factorial designs Drug release from the optimized microsphere was 71 % to 8 h The developed microsphere can effectively deliver the drug in stomach part GRAPHICAL ABSTRACT

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Unraveling putative antiulcer phytoconstituents against Helicobacter pylori urease and human H+/K+-ATPase from Jacaranda mimosifolia using UPLC-MS/MS coupled to chemometrics and molecular docking

Shoukry

El-Hawiet

El–Mezayen

et al. 2023

Microchemical Journal

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Lead phytomolecules for gastroprotective drug development

Cited by 7 publications

References 65 publications

Immunomodulatory effects and mechanisms of the extracts and secondary compounds of Zingiber and Alpinia species: a review

Immunomodulatory effects and mechanisms of the extracts and secondary compounds of Zingiber and Alpinia species: a review

Formulation and Evaluation of Oral Mucoadhesive Microspheres of Ofloxacin for Peptic Ulcer Use

Unraveling putative antiulcer phytoconstituents against Helicobacter pylori urease and human H+/K+-ATPase from Jacaranda mimosifolia using UPLC-MS/MS coupled to chemometrics and molecular docking

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