Lead Poisoning in Nonhuman Primates

Zook, Bernard C.

doi:10.1007/978-3-642-84906-0_25

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Heavy Elements Revealed in Jejunum of Simian Immunodeficiency Virus Infected Monkeys by Microparticle Induced X‐Ray Emission

Whitlow

Deoli

Vera

et al. 2020

Physica Status Solidi (a)

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Archived jejunum tissue block specimens from control and simian immunodeficiency virus‐infected rhesus macaques are characterized using particle‐induced X‐ray emission (PIXE) in a MeV ion microprobe with 2 MeV protons. The results show considerable variance in the concentration of some elements (Ti, Mn, and Fe) between viremic and control tissue. Ti, Mn, and Fe are present at levels 50‐fold lower in samples from viremic versus control monkeys, a difference markedly higher than previously reported for infections. Pb and Ti are observed particularly in the crypts of both viremic and control jejunum samples. This is likely to be caused by ingestion of paint fragments picked from the cages used to house the animals.

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