Leading infectious diseases problems in Turkey

Erdem, Hakan; Akova, Murat

doi:10.1111/1469-0691.12000

Cited by 30 publications

(28 citation statements)

References 134 publications

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“…in 2011. These observations are consistent with the results of other recent surveillance studies from Turkish hospitals and developing countries [7,32,33]. In contrast, the prevalence of ESBL-producing E. coli and K. pneumoniae in Sweden was 3.9% and 14.3% respectively [34].…”

Section: Discussionsupporting

confidence: 92%

“…These types of infections are not only difficult to treat, but also have a significant adverse economic impact on the healthcare system in terms of costs, increased length of hospital stay, morbidity, and mortality [3][4][5]. Antibiotic resistance among GNB are increasing continuously and this issue must be dealt with as a major worldwide issue [6][7][8][9]. As variations do exist among different countries and hospitals, the local resistance data is essential for appropriate initial therapy of ICU infections [10].…”

Section: Introductionmentioning

confidence: 99%

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Gram-negative bacilli causing infections in an intensive care unit of a tertiary care hospital in Istanbul, Turkey

Şenbayrak

İnan

Cevan

et al. 2014

J Infect Dev Ctries

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Introduction: This study aimed to demonstrate the changing epidemiology of infecting microorganisms and their long-term resistance profiles and to describe the microbiological point of view in anti-infective management of intensive care unit (ICU) patients. Methodology: A total of 5,690 isolates of Gram-negative bacilli were included in this study. Antibiotic susceptibility was tested using the disk diffusion method and Vitek 2 system. Chi-square tests were used for hypothesis testing. Results: The most frequently isolated organisms were A. baumannii (37.3%), P. aeruginosa (30.3%), Enterobacter spp. (10.4%), E. coli (10.4%), and Klebsiella spp. (8.9%). A. baumannii was the most frequently isolated organism from the respiratory tract (43.4%); the susceptibility rates for imipenem and meropenem decreased to 7% and 6% (p < 0.0001), respectively. The percentage of multidrug-resistant (MDR) A. baumannii isolates continuously increased from 18.7% in 2004 to 69% in 2011 (p < 0.0001), whereas MDR P. aeruginosa isolates increased from 1.5% to 22% (p < 0.0001). Carbapenem-resistant Klebsiella isolates emerged in 2010 and increased to 20% in the next year. The rates of ESBL-producing Enterobacteriaceae in the ICU was very high in 2011 -50% for E. coli and 80% for Klebsiella strains. Conclusion: The most common isolated Gram-negative bacillus in our study was A. baumannii and that the prevalence of MDR isolates has increased markedly over. Accordingly, the comparison of antibiotic resistance of other pathogens in 2004 and 2011 displayed an increasing trend. These data imply the urgent need for new and effective strategies in our hospital and in the region.

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Section: Discussionsupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Gram-negative bacilli causing infections in an intensive care unit of a tertiary care hospital in Istanbul, Turkey

Şenbayrak

İnan

Cevan

et al. 2014

J Infect Dev Ctries

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“…In addition, TB ranks the second just after HIV infection among the infectious causes of mortality. Turkey has been reported to be a low-incidence country for TB [2,3].…”

Section: Introductionmentioning

confidence: 99%

The course of spinal tuberculosis (Pott disease): results of the multinational, multicentre Backbone-2 study

Batırel

Erdem

Şengöz

et al. 2015

Clinical Microbiology and Infection

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We aimed to describe clinical, laboratory, diagnostic and therapeutic features of spinal tuberculosis (ST), also known as Pott disease. A total of 314 patients with ST from 35 centres in Turkey, Egypt, Albania and Greece were included. Median duration from initial symptoms to the time of diagnosis was 78 days. The most common complications presented before diagnosis were abscesses (69%), neurologic deficits (40%), spinal instability (21%) and spinal deformity (16%). Lumbar (56%), thoracic (49%) and thoracolumbar (13%) vertebrae were the most commonly involved sites of infection. Although 51% of the patients had multiple levels of vertebral involvement, 8% had noncontiguous involvement of multiple vertebral bodies. The causative agent was identified in 41% of cases. Histopathologic examination was performed in 200 patients (64%), and 74% were consistent with tuberculosis. Medical treatment alone was implemented in 103 patients (33%), while 211 patients (67%) underwent diagnostic and/or therapeutic surgical intervention. Ten percent of the patients required more than one surgical intervention. Mortality occurred in 7 patients (2%), and 77 (25%) developed sequelae. The distribution of the posttreatment sequelae were as follows: 11% kyphosis, 6% Gibbus deformity, 5% scoliosis, 5% paraparesis, 5% paraplegia and 4% loss of sensation. Older age, presence of neurologic deficit and spinal deformity were predictors of unfavourable outcome. ST results in significant morbidity as a result of its insidious course and delayed diagnosis because of diagnostic and therapeutic challenges. ST should be considered in the differential diagnosis of patients with vertebral osteomyelitis, especially in tuberculosis-endemic regions. Early establishment of definitive aetiologic diagnosis and appropriate treatment are of paramount importance to prevent development of sequelae.

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“…Meanwhile, the frequent use of antibiotics in human medicine and veterinary purposes have led to the emergence of antimicrobial resistance in various nosocomial isolates of gram-positive and gram-negative bacteria. However, recent guidelines limiting antibiotic applications have been promising (34).…”

Section: Zoonotic Diseases In Turkeymentioning

confidence: 99%

Overview of Zoonotic Diseases in Turkey: The One Health Concept and Future Threats

İncı¹,

Doğanay²,

Özdarendeli³

et al. 2018

TurkiyeParazitolDerg

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Zoonotic infections are globally important diseases and lead to huge economic losses in both low-and middle-income and high-income countries. Global warming, environmental and ecological changes, illegal movement of animals and humans, regional civil wars, and poverty are predisposing factors for the emergence of zoonotic infections and their distribution worldwide; they are also a big threat for the future. In addition, environmental pollution and antimicrobial resistance are immense serious threats and dangers to prevent and control zoonotic infections. The natural location of Turkey allows many emerged or re-emerged infections with zoonotic characteristics by animal movements, such as bird immigrations, and by human movements due to civil wars as seen with regional refugees. Numerous zoonotic diseases, including 37 bacterial, 13 fungal, 29 viral, 28 parasitic (3 trematodes, 7 cestodes, 10 nematodes, and 8 protozoan), and totally 107 infections, have been reported from Turkey to date. Additionally, many ectoparasitic zoonoses within 15 different arthropod groups and one leech infestation have been reported from Turkey to date. The "One Health" initiative is particularly relevant for developing strategies to combat zoonotic diseases. In this article, we review the occurrence of zoonotic diseases in man and animals in Turkey in the light of the "One Health" perspective.

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Leading infectious diseases problems in Turkey

Cited by 30 publications

References 134 publications

Gram-negative bacilli causing infections in an intensive care unit of a tertiary care hospital in Istanbul, Turkey

Gram-negative bacilli causing infections in an intensive care unit of a tertiary care hospital in Istanbul, Turkey

The course of spinal tuberculosis (Pott disease): results of the multinational, multicentre Backbone-2 study

Overview of Zoonotic Diseases in Turkey: The One Health Concept and Future Threats

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