Leadless multisite pacing: A feasibility study using wireless power transfer based on Langendorff rodent heart models

Lyu, Hongming; John, Mathews; Burkland, David; Greet, Brian; Xi, Yutao; Sampaio, Luiz C.; Taylor, Doris A.; Babakhani, Aydin; Razavi, Mehdi

doi:10.1111/jce.13738

Cited by 5 publications

(4 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Since our group first described the whole organ decellularization process, 34 we have made strides toward better preserving native ECM characteristics. 21,35,36 Decellularized samples are traditionally obtained from the whole organ, and most protocols do not distinguish the individual regions of the organs. 37 Emerging research emphasizes the need for chamber-specific samples because different regions of the heart have distinct gene expression and protein profiles.…”

Section: Discussionmentioning

confidence: 99%

Cues from human atrial extracellular matrix enrich the atrial differentiation of human induced pluripotent stem cell-derived cardiomyocytes

Mesquita¹,

Morrissey²,

Lee³

et al. 2021

Biomater. Sci.

Self Cite

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

Cues from human atrial extracellular matrix enrich the atrial differentiation of human induced pluripotent stem cell-derived cardiomyocytes

Mesquita¹,

Morrissey²,

Lee³

et al. 2021

Biomater. Sci.

Self Cite

View full text Add to dashboard Cite

show abstract

“…Not only is the need for intravascular leads eliminated, but synchronized and leadless pacing across different chambers becomes feasible, which offers the flexibility in customizing patient-specific CRTs. Prior studies have www.nature.com/scientificreports www.nature.com/scientificreports/ investigated wirelessly powered single-site cardiac pacing on rodent, rabbit and open-chest porcine models 4,5,21 . This work takes a stride further to demonstrate the synchronization of multiple leadless pacemakers for the first time in a closed-chest porcine model.…”

mentioning

confidence: 99%

Synchronized Biventricular Heart Pacing in a Closed-chest Porcine Model based on Wirelessly Powered Leadless Pacemakers

Lyu

John²,

Burkland

et al. 2020

Sci Rep

Self Cite

View full text Add to dashboard Cite

About 30% of patients with impaired cardiac function have ventricular dyssynchrony and seek cardiac resynchronization therapy (CRT). In this study, we demonstrate synchronized biventricular (BiV) pacing in a leadless fashion by implementing miniaturized and wirelessly powered pacemakers. With their flexible form factors, two pacemakers were implanted epicardially on the right and left ventricles of a porcine model and were inductively powered at 13.56 MHz and 40.68 MHz industrial, scientific, and medical (ISM) bands, respectively. The power consumption of these pacemakers is reduced to µW-level by a novel integrated circuit design, which considerably extends the maximum operating distance. Leadless BiV pacing is demonstrated for the first time in both open-chest and closed-chest porcine settings. The clinical outcomes associated with different interventricular delays are verified through electrophysiologic and hemodynamic responses. The closed-chest pacing only requires the external source power of 0.3 W and 0.8 W at 13.56 MHz and 40.68 MHz, respectively, which leads to specific absorption rates (SARs) 2-3 orders of magnitude lower than the safety regulation limit. This work serves as a basis for future wirelessly powered leadless pacemakers that address various cardiac resynchronization challenges.

show abstract

“…The utilization of animal models has also been demonstrated in [46], where the authors conducted experiments on euthanized rats. The authors in [41] consider male human mannequins, while the authors in [48] employed Ex vivo Langendorff heart models. Figure 1 depicts the typical WPT system for PPM using magnetic coils.…”

Section: A Recent Development In Wpt For Pacemakersmentioning

confidence: 99%

“…SAR can be defined as a time derivative of incremental energy dissipated in or absorbed by an incremental mass within a given density in a known volume [54]. Generally, the SAR value can be estimated as [55]: As in Table I, Studies [45], [46], and study [48] did not specify the SAR standard in their study analysis. However, the majority of the selected studies (i.e., 7 studies) adopted the IEEE standard as their SAR constraint, while the study [49] adopted the ICNIRP standard for the SAR analysis.…”

Section: B Specific Absorption Rate (Sar)mentioning

confidence: 99%

Coil-based Wireless Power Transfer for Implanted Pacemakers: A Brief Review

Hisan,

Sabila,

Amri

2023

Jurnal Teknik Elektro

View full text Add to dashboard Cite

Nowadays, implanted permanent pacemakers (PPM) users need to undergo periodic pacemaker replacement surgery. The surgery is needed since the pacemaker's battery is usually depleted in 5-10 years. This surgery, although poses relatively low health risks, is inconvenient for PPM users. Moreover, the surgery can still be dangerous for PPM users, especially considering that most of the users are elderly. PPM replacement surgery is also costly. In addition to the costs of the surgery itself, the PPM users need to bear the price of the new PPM every time they undergo surgery. Currently, when the PPM's battery runs out, the whole PPM needs to be replaced. This is conducted to prevent the possibility of a leak in the battery seal, which might allow the body fluids to enter the PPM. Typically, once a battery is inserted into the PPM, it will be permanently sealed along with all other electronic components, and thus, battery-only replacement is impossible. Thanks to the recent advancement of wireless power transfer (WPT) technology, a PPM replacement surgery might no longer be necessary in the near future. This article presents a brief review of the current state of coil-based WPT technology and its potential applications in pacemakers. Depending on the load and transmission distance, a recent WPT system for PPM could achieve WPT efficiency as high as 97.91% on air and 78% on pig tissue medium. In terms of output power, recent works that we have summarized showed that they are able to transmit power up to 5W on a WPT system implemented on a human phantom. We also discuss the challenges, limitations, and future prospects for WPT in the medical field, particularly for PPM applications.

show abstract

Leadless multisite pacing: A feasibility study using wireless power transfer based on Langendorff rodent heart models

Abstract: WPT provides a feasible option for multisite, wireless cardiac pacing. While the current system remains limited in design, it offers support and a conceptual framework for future iterations and eventual clinical utility.

Cited by 5 publications

References 29 publications

Cues from human atrial extracellular matrix enrich the atrial differentiation of human induced pluripotent stem cell-derived cardiomyocytes

Cues from human atrial extracellular matrix enrich the atrial differentiation of human induced pluripotent stem cell-derived cardiomyocytes

Synchronized Biventricular Heart Pacing in a Closed-chest Porcine Model based on Wirelessly Powered Leadless Pacemakers

Coil-based Wireless Power Transfer for Implanted Pacemakers: A Brief Review

Contact Info

Product

Resources

About