2023
DOI: 10.1111/jnc.16008
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Leakage beyond the primary lesion: A temporal analysis of cerebrovascular dysregulation at sites of hippocampal secondary neurodegeneration following cortical photothrombotic stroke

Rebecca J. Hood,
Sonia Sanchez‐Bezanilla,
Daniel J. Beard
et al.

Abstract: We have previously demonstrated that a cortical stroke causes persistent impairment of hippocampal‐dependent cognitive tasks concomitant with secondary neurodegenerative processes such as amyloid‐β accumulation in the hippocampus, a region remote from the primary infarct. Interestingly, there is emerging evidence suggesting that deposition of amyloid‐β around cerebral vessels may lead to cerebrovascular structural changes, neurovascular dysfunction, and disruption of blood–brain barrier integrity. However, the… Show more

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