Lean body mass but not body fat mass is related with leukocyte telomere length in children

Hong, Zhen; Lin, Xue; Zhou, Yingyu; Zheng, Guo Dong; Liao, Xuemei; Wei, Qiujing; Zhang, Zheqing; Liang, Jingjing

doi:10.1038/s41366-022-01239-4

Cited by 3 publications

(2 citation statements)

References 42 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A recent prospective study found a significant correlation between longer LTL at birth and higher lean mass in late infancy [ 45 ]. Another cross-sectional study investigated the relationship between skeletal muscle mass and LTL in the pediatric population (aged 6–11 years) and reached similar results [ 46 ]. These results to some extent supported the conclusion of our current MR analysis, as assuming shorter LTL to be a cause for muscle mass reduction may be more reasonable than assuming muscle mass reduction to be a cause for shorter LTL in infants and young children.…”

Section: Discussionmentioning

confidence: 85%

Leukocyte telomere length and sarcopenia-related traits: A bidirectional Mendelian randomization study

Wang,

Li,

Zhang

et al. 2024

PLoS ONE

View full text Add to dashboard Cite

Accumulating evidence indicated that leukocyte telomere length (LTL) was related to sarcopenia. However, it is still not clear whether the association of changes in LTL with sarcopenia is likely to be causal, or could be explained by reverse causality. Thus, we carried on bidirectional Mendelian randomization (MR) and multivariable MR analyses to identify the causal relationship between LTL and sarcopenia-related traits. Summary-level data and independent variants used as instruments came from large genome-wide association studies of LTL (472,174 participants), appendicular lean mass (450,243 participants), low grip strength (256,523 participants), and walking pace (450,967 participants). We identified suggestive association of longer LTL with larger appendicular lean mass [odds ratio (OR) = 1.053; 95% confidence interval (CI), 1.009–1.099; P = 0.018], and causal association of longer LTL with a lower risk of low grip strength (OR = 0.915; 95% CI, 0.860–0.974; P = 0.005). In the reverse MR analysis, we also observed a positive causal association between walking pace and LTL (OR = 1.252; 95% CI, 1.121–1.397; P < 0.001). Similar results can be repeated in sensitivity analyses. While in the multivariable MR analysis, the estimate of the impact of walking pace on LTL underwent a transformation after adjusting for T2DM (OR = 1.141; 95%CI: 0.989–1.317; P = 0.070). The current MR analysis supported a causal relationship between shorter telomere length and both low muscle mass and strength. Additionally, walking pace may affect LTL through T2DM.

show abstract

Section: Discussionmentioning

confidence: 85%

Leukocyte telomere length and sarcopenia-related traits: A bidirectional Mendelian randomization study

Wang,

Li,

Zhang

et al. 2024

PLoS ONE

View full text Add to dashboard Cite

show abstract

“…In particular, telomere shortening is strongly associated with a low BMD (13,52). The mechanism by which telomere shortening causes osteoporosis has come to light through experiments using mice or individuals harboring germline mutations in genes implicated in telomere maintenance (15,40,44,45,48,50,(52)(53)(54)(55)(56)(57)(58)(59). However, only a limited number of studies contradicted the positive association between telomere shortening and the aggravation of skeletal pathology (60)(61)(62)(63).…”

Section: Clinical Studies Regarding Telomere Length and Osteoporosismentioning

confidence: 99%

Telomere length as a predictive biomarker in osteoporosis (Review)

Kakridonis,

Pneumatikos,

Vakonaki

et al. 2023

Biomed Rep

View full text Add to dashboard Cite

Telomeres are the ends of chromosomes that protect them from DNA damage. There is evidence to suggest that telomere shortening appears with advanced age. Since aging is a significant risk factor for developing age-related complications, it is plausible that telomere shortening may be involved in the development of osteoporosis. The present review summarizes the potential of telomere shortening as a biomarker for detecting the onset of osteoporosis. For the purposes of the present review, the following scientific databases were searched for relevant articles: PubMed/NCBI, Cochrane Library of Systematic Reviews, Scopus, Embase and Google Scholar. The present review includes randomized and non-randomized controlled studies and case series involving humans, irrespective of the time of their publication. In six out of the 11 included studies providing data on humans, there was at least a weak association between telomere length and osteoporosis, with the remaining studies exhibiting no such association. As a result, telomere shortening may be used as a biomarker or as part of a panel of biomarkers for tracking the onset and progression of osteoporosis.

show abstract

Association Between Adverse Early Life Factors and Telomere Length in Middle and Late Life

Lin,

Luo,

Zhu

et al. 2024

Innovation in Aging

View full text Add to dashboard Cite

Background and Objectives Telomere length (TL) has been acknowledged as biomarker of biological aging. Numerous investigations have examined associations between individual early life factors and leukocyte TL; however, the findings were far from consistent. Research Design and Methods We evaluated the relationship between individual and combined early life factors and leukocytes TL in middle and late life using data from the UK Biobank. The early life factors (e.g., maternal smoking, breastfeeding, birth weight, and comparative body size and height to peers at age 10) were measured. The regression coefficients (β) and 95% confidence interval (CI) were applied to assess the link of the early life factors and TL in adulthood. Flexible parametric survival models incorporated age to calculate the relationship between early life factors and life expectancy. Results Exposure to maternal smoking, lack of breastfeeding, low birth weight, and shorter height compared to peers at age 10 were identified to be associated with shorter TL in middle and older age according to the large population-based study with 197,504 participants. Individuals who experienced more than three adverse early life factors had the shortest TL in middle and late life (β = −0.053; 95% CI, −0.069 to −0.038; p < 0.0001), as well as an average of 0.54 years of life loss at the age of 45 and 0.49 years of life loss at the age of 60, compared to those who were not exposed to any early life risk factors. Discussion and Implications Early life factors including maternal smoking, non-breastfed, low birth weight, and shorter height compared to peers at age 10 were associated with shorter TL in later life. In addition, an increased number of the aforementioned factors was associated with a greater likelihood of shorter TL in adulthood, as well as a reduced life expectancy.

show abstract

Lean body mass but not body fat mass is related with leukocyte telomere length in children

Cited by 3 publications

References 42 publications

Leukocyte telomere length and sarcopenia-related traits: A bidirectional Mendelian randomization study

Leukocyte telomere length and sarcopenia-related traits: A bidirectional Mendelian randomization study

Telomere length as a predictive biomarker in osteoporosis (Review)

Association Between Adverse Early Life Factors and Telomere Length in Middle and Late Life

Contact Info

Product

Resources

About