Lean mass and associated factors in women with PCOS with different phenotypes

Context Controversial results have emerged regarding whether PCOS is protective or increases the risk of bone frailty. Objective This study investigated whether the PCOS condition affects bone parameters of premenopausal women. This is an update for a previous meta-analysis published in 2019. Data Sources We searched MEDLINE and Embase Study Selection Studies were considered eligible for the update if published in English between the 1st of October 2018 and the 31st of December 2023. The diagnosis of PCOS should be based on NIH criteria, the Rotterdam Consensus, AE-PCOS society criteria, or ICD codes in women over 18 years old. Only records with the Newcastle-Ottawa Scale > 6 were selected for data extraction. Data extraction Data were extracted by two independent reviewers. Data Synthesis We identified 31 studies that met the inclusion criteria for qualitative analysis from 3322 studies in the whole period (1990-2023). Overall, cross-sectional studies included 1822 individuals with PCOS and 1374 controls, while cohort studies incorporated 30305 women with PCOS and 101907 controls. Contrasting profiles emerged after stratification using a BMI cutoff of 27 kg/m2. Individuals with PCOS and a BMI <27 kg/m2 exhibited lower vertebral and non-vertebral bone density, reduced bone turnover marker (osteocalcin), and increased bone resorption marker (CTX) levels. Conversely, individuals with PCOS and a BMI >27 kg/m2 exhibited increased vertebral and non-vertebral BMD, with no significant changes in bone formation and resorption markers (except osteocalcin). Conclusions The findings of this study alert for a low bone mass, low bone formation, and increased bone resorption PCOS with a BMI <27 kg/m2.

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WITHDRAWN: Exploring Adipsin, Irisin, and Osteopontin as Biomarkers in Polycystic Ovary Syndrome and Their Associations with Metabolic Alterations: A prospective, case-control study

Duzenli,

Yurtcu,

Keyif

et al. 2024

Preprint

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Background Polycystic Ovary Syndrome (PCOS) is a prevalent endocrine disorder in premenopausal women, often associated with metabolic alterations. This study aimed to assess adipsin, irisin, and osteopontin levels and correlate the measurements with the metabolic changes in PCOS patients, with a scientific rationale rooted in exploring potential links between these biomarkers and the pathophysiology of PCOS. Methods A prospective, case-control study was conducted on patients diagnosed with PCOS. Group PCOS comprised patients with PCOS, while healthy women were included in Group Control. Serum adipsin, irisin, and osteopontin levels were measured, and various demographic and clinical characteristics and laboratory parameters related to the metabolic status of PCOS were assessed. Results The study included 96 PCOS patients and 80 healthy women. The patients in Group PCOS were significantly younger than those in Group Control (p < 0.001). There were significantly more obese patients in Group PCOS than in Group Control (p = 0.013). PCOS patients had higher serum adipsin (p = 0.020) and lower osteopontin levels (p < 0.001) than healthy women, with obesity and age influencing these differences. The predictive power of osteopontin, with an AUC value of 0.802, was superior to adipsin, with an AUC value of 0.602, in diagnosing PCOS. Besides, osteopontin, in combination with adipsin, had the highest AUC value (AUC = 0.817) than the other dual or triple combinations. Conclusion This study suggests potential links between adipsin, osteopontin, and irisin and PCOS. However, further research is needed to fully understand their roles and clinical implications in PCOS and its associated metabolic changes. The findings highlight the influence of age and obesity on these biomarkers and their relationship with PCOS, shedding light on the complex pathophysiology of the syndrome.

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Lean mass and associated factors in women with PCOS with different phenotypes

Cited by 7 publications

References 57 publications

Relationship between serum apelin, visfatin levels, and body composition in Polycystic Ovary Syndrome patients

Relationship between serum apelin, visfatin levels, and body composition in Polycystic Ovary Syndrome patients

Contrasting Bone Profiles in PCOS Are Related to BMI: A Systematic Review and Meta-analysis

WITHDRAWN: Exploring Adipsin, Irisin, and Osteopontin as Biomarkers in Polycystic Ovary Syndrome and Their Associations with Metabolic Alterations: A prospective, case-control study

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