Learned desires

Akker, Karolien van den

doi:10.26481/dis.20170201kvda

Cited by 7 publications

(8 citation statements)

References 199 publications

(418 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…As shown in the TeNT structure [34] this Trp1289 plays a critical role in maintaining hydrophobic interactions between the toxin and the ganglioside galactose ring. Similar stacking interactions between a tryptophan side chain and a galactose ring have been observed both in cholera toxin [39] and heat-labile enterotoxin [40,41] structures com- Fig. 3.…”

Section: Ganglioside Bindingsupporting

confidence: 68%

Structure‐based sequence alignment for the β‐trefoil subdomain of the clostridial neurotoxin family provides residue level information about the putative ganglioside binding site

et al. 2000

View full text Add to dashboard Cite

Clostridial neurotoxins embrace a family of extremely potent toxins comprised of tetanus toxin (TeNT) and seven different serotypes of botulinum toxin (BoNT/A^G). The L L-trefoil subdomain of the C-terminal part of the heavy chain (H C ), responsible for ganglioside binding, is the most divergent region in clostridial neurotoxins with sequence identity as low as 15%. We re-examined the alignment between family sequences within this subdomain, since in this region all alignments published to date show obvious inconsistencies with the L L-trefoil fold. The final alignment was obtained by considering the general constraints imposed by this fold, and homology modeling studies based on the TeNT structure. Recently solved structures of BoNT/A confirm the validity of this structure-based approach. Taking into account biochemical data and crystal structures of TeNT and BoNT/A, we also re-examined the location of the putative ganglioside binding site and, using the new alignment, characterized this site in other BoNT serotypes. ß

show abstract

Section: Ganglioside Bindingsupporting

confidence: 68%

Structure‐based sequence alignment for the β‐trefoil subdomain of the clostridial neurotoxin family provides residue level information about the putative ganglioside binding site

et al. 2000

View full text Add to dashboard Cite

show abstract

“…The involvement of HSP in the pathogenesis of autoimmune diseases including rheumatoid arthritis, multiple sclerosis and insulin dependent diabetes, is supported by many findings. There is significant sequence homology between HSP and many self antigens, including those involved in autoimmunity (48,49). T lymphocyte cross-reactivity has been demonstrated between Mycobacterial HSP and its human homologue (50,51).…”

Section: Discussionmentioning

confidence: 99%

Heat shock protein expression in oral lichen planus

Sugerman

Savage

et al. 1995

J Oral Pathology Medicine

View full text Add to dashboard Cite

To assess the potential role of heat shock protein (HSP) in the pathogenesis of oral lichen planus (OLP), sections of OLP, normal oral mucosa, non-specific oral ulceration (NSOU) and dysplastic OLP were assessed for HSP expression using avidin-biotin complex immunohistochemistry with an anti-HSP 70 polyclonal antibody. There were statistically significant differences in both the vertical and horizontal staining distribution when other groups were compared with the OLP group (p < 0.01). Using microdensitometry, the mean staining intensity in OLP, dysplastic OLP and NSOU was elevated in comparison with normal oral mucosa (p < 0.001). In a standard tritiated thymidine uptake assay, lymphocytes extracted from nine OLP lesions demonstrated significant proliferation when stimulated with purified protein derivative (PPD), of which HSP is a major constituent, with stimulation indices ranging from 2 to 132. These results are consistent with the hypothesis that, in OLP patients, diverse exogenous agents may cause upregulated expression of HSP by oral mucosal keratinocytes. A reaction of cytotoxic T lymphocytes to these activated keratinocytes may then result in the tissue destruction which is characteristic of OLP lesions.

show abstract

“…Finally, it has been shown that the frequency of M-Ig in various strains of mice is related to the Igh. M-Ig in C57BLl6-Igh-6a congenic mice appear with a low frequency and in BALBlc-Igh-6b congenic mice with a high frequency as related to the parental strains [19]. Thus, it might be expected that B cells that express allotype b would be more likely to give rise to M-Ig.…”

Section: Discussionmentioning

confidence: 99%

Evidence for selective pressure in the appearance of monoclonal immunoglobulins during aging: Studies in M54 μ‐transgenic mice

et al. 1993

View full text Add to dashboard Cite

Serum monoclonal immunoglobulins (M-Ig) appear during aging but little is known about the immunological factors which lead to their development. We have investigated whether such M-Ig occur as a clonally random process or result from V-region-directed selective pressures. We have analyzed a mu-transgenic mouse strain in which over 95% of all splenic B cells express the transgenic mu chain. All endogenous repertoire and mu-chain diversity are generated from the 5% of the B cells which express endogenous mu chains. Not one of the M-Ig detected in these mice were of transgene origin alone; 11 of the 14 M-Ig did not express a mu chain and none of the mu chain containing M-Ig expressed the transgene allotype alone. This observation suggests that the B cells giving rise to M-Ig are heavily selected from among the small number of B cells which express endogenous Ig. The selective factors that might act on the endogenous B cell pools are discussed.

show abstract

Learned desires

Cited by 7 publications

References 199 publications

Structure‐based sequence alignment for the β‐trefoil subdomain of the clostridial neurotoxin family provides residue level information about the putative ganglioside binding site

Structure‐based sequence alignment for the β‐trefoil subdomain of the clostridial neurotoxin family provides residue level information about the putative ganglioside binding site

Heat shock protein expression in oral lichen planus

Evidence for selective pressure in the appearance of monoclonal immunoglobulins during aging: Studies in M54 μ‐transgenic mice

Contact Info

Product

Resources

About