Indonesia is prone to natural hazards, which have continued to occur even during the coronavirus disease 2019 (COVID-19) pandemic. Therefore, this study explored the response and strategy employed by Muhammadiyah, one of Indonesia’s moderate Islamic organisations, in dealing with natural hazards during this pandemic. A qualitative descriptive method was used in this study, and the data collection procedure involved finding related literature, reports, and decrees. Online interviews were also conducted with the Muhammadiyah Disaster Management Center (MDMC) administration to strengthen the data. Subsequently, this study discovered that Muhammadiyah responded by aiding victims of natural hazards, which occurred in various regions in Indonesia during the COVID-19 pandemic. The strategies employed comprise Muhammadiyah COVID-19 Command Center (MCCC) to handle COVID-19, alongside essential recommendations to the MDMC network throughout Indonesia and the various arms of the government for dealing with natural hazards during the pandemic. Also, it showed commitment to handling these hazards by establishing a standard operating procedure for Muhammadiyah volunteers and represented Indonesia during a presentation at the World Health Organization.