1986
DOI: 10.1016/0031-9384(86)90205-2
|View full text |Cite
|
Sign up to set email alerts
|

Learning and memory disabilities in young adult rats from mildly zinc deficient dams

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
3
1
1

Citation Types

3
62
0
2

Year Published

1994
1994
2015
2015

Publication Types

Select...
9

Relationship

0
9

Authors

Journals

citations
Cited by 103 publications
(67 citation statements)
references
References 25 publications
3
62
0
2
Order By: Relevance
“…Zinc participates in the regulation of cell proliferation in several ways; it is essential to enzyme functions, which influence cell division and proliferation. Several studies have shown that zinc deficiency altered postnatal development of the brain (Halas et al, 1983(Halas et al, , 1986. Thus, the evidences outlined above confirm that zinc is an essential transition element in cell division and proliferation, and further suggests that this element has a critical role in neurogenesis in the adult rodent brain.…”
Section: Discussionmentioning
confidence: 66%
“…Zinc participates in the regulation of cell proliferation in several ways; it is essential to enzyme functions, which influence cell division and proliferation. Several studies have shown that zinc deficiency altered postnatal development of the brain (Halas et al, 1983(Halas et al, , 1986. Thus, the evidences outlined above confirm that zinc is an essential transition element in cell division and proliferation, and further suggests that this element has a critical role in neurogenesis in the adult rodent brain.…”
Section: Discussionmentioning
confidence: 66%
“…Maternal zinc deprivation during the last one third of pregnancy in rats and monkeys adversely affected subsequent behavior of offspring [24]. Similarly impairments in learning and memory impairment were observed in adult rats whose mothers were subjected to severe zinc deficiency during pregnancy and lactation [9], [10]. Histological abnormalities were evident in the cerebellum and hippocampus in rats with late prenatal and/or early postnatal zinc deficiency [6][7][8], [25], [26].…”
Section: Discussionmentioning
confidence: 99%
“…Granule cell neurons were sharply reduced in cell number, Purkinje cell maturation was impaired, and differentiation of basket and stellate cell dendrites was reduced. In other studies, adult rats showed significant learning and memory deficits if their mothers were mildly or severely zinc deficient during late pregnancy and lactation [9], [10]. In our previous studies, we used a different model, in which maternal zinc deficiency was initiated on the first day of pregnancy and continued throughout the period of lactation.…”
Section: Introductionmentioning
confidence: 99%
“…Some of these effects may be irreversible because marginal zinc deficiency during gestation and lactation leads to impaired working memory performance on the radial arm maze after dietary zinc repletion [41]. Similarly, gestational zinc deficiency with repletion at birth leads to an impairment in social behavior consistent with models of autism in mice [42].…”
Section: Discussionmentioning
confidence: 99%