Learning and Memory Impairment Induced by Amyloid Beta Peptide and Effects of Thymol on Hippocampal Synaptic Plasticity in Rats Fed a High-Fat Diet That Received Amyloid Beta

Abstract

Thymol is a natural phenolic compound that is present in various plants; the significant antioxidant activities of Thymol may be helpful in preventing the progress of various oxidative stress-related diseases. Recent studies have confirmed that antioxidant-rich foods play a vital role in the disease prevention of neurodegenerative diseases, including Alzheimer’s disease (AD). We examined the protective and therapeutic effects of Thymol on the Aβ-induced long-term potentiation (LTP) impairments in rats fed a high-fat diet. LTP is a type of synaptic activity that has been thoroughly studied in the hippocampus and is thought to be the neural correlate of learning and memory. If Thymol is protective against AD-related impairments, then natural therapeutic agents based on the structure of Thymol could be used to protect against oxidative stress-related illnesses, such as AD.