2012
DOI: 10.1016/j.neurobiolaging.2011.04.005
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Learning capabilities and CA1-prefrontal synaptic plasticity in a mice model of accelerated senescence

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Cited by 31 publications
(24 citation statements)
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“…3D). This type of delayed LTP has been reported in previous studies (Ló pez-Ramos et al 2011). Interestingly, and as already reported in acute experiments (Robbe et al 2002;Goto and Grace 2005), HFS of the mPFC evoked a delayed LTD in the ipsilateral NAc (Fig.…”
Section: Resultssupporting
confidence: 89%
“…3D). This type of delayed LTP has been reported in previous studies (Ló pez-Ramos et al 2011). Interestingly, and as already reported in acute experiments (Robbe et al 2002;Goto and Grace 2005), HFS of the mPFC evoked a delayed LTD in the ipsilateral NAc (Fig.…”
Section: Resultssupporting
confidence: 89%
“…In our study, first, we demonstrated that excess formaldehyde suppresses hippocampal LTP and spatial memory formation in rats (Figs. 2 and 4), consistent with other reports of hippocampal LTP suppression and memory decline in aged mice and rats (Almaguer et al 2002;Chapman et al 1999;Kamal et al 2005), STZ-induced diabetic SD rats (Reisi et al 2010), and Alzheimer's disease animal models such as APP transgenic mice (Gureviciene et al 2004), APP/ PS1 mice (Gengler et al 2010), and SAMP8 (López-Ramos et al 2012). Second, we showed that excess formaldehyde non-specifically blocks the NR1/NR2B subunits of the NMDA receptor in vitro (Fig.…”
Section: Discussionsupporting
confidence: 90%
“…Abundant evidence shows that memory decline occurs and hippocampal long-term potentiation (LTP) is impaired in aged animals (Almaguer et al 2002;Chapman et al 1999;Kamal et al 2005) and memory-deteriorating animal models such as amyloid precursor protein (APP) transgenic mice (Gureviciene et al 2004), APP/PS1 mice (Gengler et al 2010), and senescence-acceleratedprone 8 mice (SAMP8) (López-Ramos et al 2012). NR2B, one of the subunits of N-methyl-D-aspartate (NMDA) receptor, is critical in regulating the agedependent synaptic plasticity and memory formation (Tang et al 1999).…”
mentioning
confidence: 99%
“…SAMP8 presented not only similar characteristics to aged humans, such as shorter lifespan, lordosis, reduced physical activity, and hair loss [46,47], but also some neurodegenerative features, such as early onset of learning and memory deficits [48], altered emotions and abnormal circadian rhythm [49,50], neuronal cell loss [51], and reduction in the release of neurotransmitters in the brain [52,53]. Besides, impairment of mitochondrial functions has been shown in SAMP8 brain at a relatively early age compared to SAMR1 mice [29].…”
Section: Samp8 Postulated As An Early Model Of Alzheimer's Diseasementioning
confidence: 91%