Learning from Nature: β‐Sheet‐Mimicking Copolymers Get Organized

König, Hannah M.; Kilbinger, Andreas F. M.

doi:10.1002/anie.200701167

Cited by 89 publications

(59 citation statements)

References 53 publications

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“…[ 228 ] For example, peptide directed self-assembly of nanoparticles can form alpha helices and beta sheets to form peptide-particle hybrids. [ 226 ] In a HEPES buffer solution, parallel beta sheets of peptides (C 12 -AYSSGAPPMPPF) spontaneously form and take on a left-handed helical conformation due to the aliphatic tails of the peptides. When mixed with a reactive acid (HAuC l4 ), gold nanoparticles precipitate onto the peptide forming a gold nanoparticle helix.…”

Section: Reviewmentioning

confidence: 99%

Engineering of Micro‐ and Nanostructured Surfaces with Anisotropic Geometries and Properties

Tawfick¹,

Volder²,

Copic³

et al. 2012

Advanced Materials

217

179

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Widespread approaches to fabricate surfaces with robust micro- and nanostructured topographies have been stimulated by opportunities to enhance interface performance by combining physical and chemical effects. In particular, arrays of asymmetric surface features, such as arrays of grooves, inclined pillars, and helical protrusions, have been shown to impart unique anisotropy in properties including wetting, adhesion, thermal and/or electrical conductivity, optical activity, and capability to direct cell growth. These properties are of wide interest for applications including energy conversion, microelectronics, chemical and biological sensing, and bioengineering. However, fabrication of asymmetric surface features often pushes the limits of traditional etching and deposition techniques, making it challenging to produce the desired surfaces in a scalable and cost-effective manner. We review and classify approaches to fabricate arrays of asymmetric 2D and 3D surface features, in polymers, metals, and ceramics. Analytical and empirical relationships among geometries, materials, and surface properties are discussed, especially in the context of the applications mentioned above. Further, opportunities for new fabrication methods that combine lithography with principles of self-assembly are identified, aiming to establish design principles for fabrication of arbitrary 3D surface textures over large areas.

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Section: Reviewmentioning

confidence: 99%

Engineering of Micro‐ and Nanostructured Surfaces with Anisotropic Geometries and Properties

Tawfick¹,

Volder²,

Copic³

et al. 2012

Advanced Materials

217

179

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“…Because of their tunable conformational structure and hierarchical self-assembly, peptide-polymer hybrid block copolymers have been reviewed, both in solution and in the solid state, with an emphasis on the supramolecular structure formation [3,12,13]. The current research trends are involved in the combination of their special organization and behavior with other kind of properties.…”

Section: Open Accessmentioning

confidence: 99%

Hybrid Block Copolymers Constituted by Peptides and Synthetic Polymers: An Overview of Synthetic Approaches, Supramolecular Behavior and Potential Applications

Morell

Puiggalı́

2013

Polymers

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Hybrid block copolymers based on peptides and synthetic polymers, displaying different types of topologies, offer new possibilities to integrate the properties and functions of biomacromolecules and synthetic polymers in a single hybrid material. This review provides a current status report of the field concerning peptide-synthetic polymer hybrids. The first section is focused on the different synthetic approaches that have been used within the last three years for the preparation of peptide-polymer hybrids having different topologies. In the last two sections, the attractive properties, displayed in solution or in the solid state, together with the potential applications of this type of macromolecules or supramolecular systems are highlighted.

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“…The fact that properties of a peptide domain can be imposed on the whole hybrid hydrogel [10] suggests that the supramolecular organization of hybrid materials is driven mainly by the biorecognition of peptide segments. This suggests that the understanding of self-assembly processes will undoubtedly contribute to a better understanding of the processes occurring in nature [11]. …”

Section: Introductionmentioning

confidence: 99%

Peptide-directed self-assembly of hydrogels

2009

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This review focuses on the self-assembly of macromolecules mediated by the biorecognition of peptide/protein domains. Structures forming α-helices and β-sheets have been used to mediate self-assembly into hydrogels of peptides, reactive copolymers and peptide motifs, block copolymers, and graft copolymers. Structural factors governing the self-assembly of these molecules into precisely defined three-dimensional structures (hydrogels) are reviewed. The incorporation of peptide motifs into hybrid systems, composed of synthetic and natural macromolecules, enhances design opportunities for new biomaterials when compared to individual components.

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Learning from Nature: β‐Sheet‐Mimicking Copolymers Get Organized

Cited by 89 publications

References 53 publications

Engineering of Micro‐ and Nanostructured Surfaces with Anisotropic Geometries and Properties

Engineering of Micro‐ and Nanostructured Surfaces with Anisotropic Geometries and Properties

Hybrid Block Copolymers Constituted by Peptides and Synthetic Polymers: An Overview of Synthetic Approaches, Supramolecular Behavior and Potential Applications

Peptide-directed self-assembly of hydrogels

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