Learning Relationships Between Chemical and Physical Stability for Peptide Drug Development

Fine, Jonathan; Wijewardhane, Prageeth R.; Mohideen, Sheik Dawood Beer; Smith, Katelyn J.; Bothe, Jameson R.; Krishnamachari, Yogita; Andrews, Alexandra; Liu, Yong; Chopra, Gaurav

doi:10.1007/s11095-023-03475-3

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Peptide-guided Fluorescence Imaging Of Cellular Senescence1

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2023

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“…Peptides, built from amino acids, participate in various cellular processes and are some of the most important biomolecules in living systems [ 106 ]. As a small version of proteins, peptides show unique features of flexible conformation, high stability, and adjustable affinity [ 107 , 108 , 109 , 110 ].…”

Section: Peptide-guided Fluorescence Imaging Of Cellular Senescencementioning

confidence: 99%

Molecularly Targeted Fluorescent Sensors for Visualizing and Tracking Cellular Senescence

He,

Xu,

et al. 2023

Biosensors

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Specific identification and monitoring of senescent cells are essential for the in-depth understanding and regulation of senescence-related life processes and diseases. Fluorescent sensors providing real-time and in situ information with spatiotemporal resolution are unparalleled tools and have contributed greatly to this field. This review focuses on the recent progress in fluorescent sensors for molecularly targeted imaging and real-time tracking of cellular senescence. The molecular design, sensing mechanisms, and biological activities of the sensors are discussed. The sensors are categorized by the types of markers and targeting ligands. Accordingly, their molecular recognition and fluorescent performance towards senescence biomarkers are summarized. Finally, the perspective and challenges in this field are discussed, which are expected to assist future design of next-generation sensors for monitoring cellular senescence.

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Section: Peptide-guided Fluorescence Imaging Of Cellular Senescencementioning

confidence: 99%

Molecularly Targeted Fluorescent Sensors for Visualizing and Tracking Cellular Senescence

He,

Xu,

et al. 2023

Biosensors

View full text Add to dashboard Cite

show abstract

Learning Relationships Between Chemical and Physical Stability for Peptide Drug Development

Cited by 1 publication

References 32 publications

Molecularly Targeted Fluorescent Sensors for Visualizing and Tracking Cellular Senescence

Molecularly Targeted Fluorescent Sensors for Visualizing and Tracking Cellular Senescence

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