Lecithin-based deferoxamine nanoparticles accelerated cutaneous wound healing in diabetic rats

Qayoom, Asif; Aneesha, V. A.; Anagha, S.; Dar, Javeed Ahmad; Kumar, Pawan; Kumar, Dinesh

doi:10.1016/j.ejphar.2019.172478

Cited by 19 publications

(15 citation statements)

References 44 publications

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“…The continuous inflammatory response is characterized by the upregulation of proinflammatory factors and the existence of M1 macrophages, which affect the healing of ulcers . Different bioactive cargos such as cytokines, hydrogels, and drugs have been used to regulate the inflammatory reaction through inducing the M1-M2 switch of macrophages, which then accelerated the healing of both normal and chronic wounds. − Several studies have revealed that DFO could accelerate the healing of diabetic wounds through modulating the inflammation of macrophages and angiogenesis. , Therefore, the modulation of inflammation was investigated at day 7 after implantation. Several studies revealed that silk materials restrained the expression of proinflammatory factors, strengthening applications in tissue regeneration. − Compared with the control group, the expression of TNF-α was significantly downregulated in the SG groups (Figure A), which revealed the low inflammatory reaction to the SG materials.…”

Section: Resultsmentioning

confidence: 99%

“…55−57 Several studies have revealed that DFO could accelerate the healing of diabetic wounds through modulating the inflammation of macrophages and angiogenesis. 58,59 Therefore, the modulation of inflammation was investigated at day 7 after implantation. Several studies revealed that silk materials restrained the expression of proinflammatory factors, strengthening applications in tissue regeneration.…”

Section: Secretion Of Growthmentioning

confidence: 99%

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Injectable Desferrioxamine-Laden Silk Nanofiber Hydrogels for Accelerating Diabetic Wound Healing

Ding

Zhang

Guo

et al. 2021

ACS Biomater. Sci. Eng.

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Dysangiogenesis and chronic inflammation are two critical reasons for diabetic foot ulcers. Desferrioxamine (DFO) was used clinically in the treatment of diabetic foot ulcers by repeated injections because of its capacity to induce vascularization. Biocompatible carriers that release DFO slowly and facilitate healing simultaneously are preferable options to accelerate the healing of diabetic wounds. Here, DFO-laden silk nanofiber hydrogels that provided a sustained release of DFO for more than 40 days were used to treat diabetic wounds. The DFO-laden hydrogels stimulated the healing of diabetic wounds. In vitro cell studies revealed that the DFO-laden hydrogels modulated the migration and gene expression of endothelial cells, and they also tuned the inflammation behavior of macrophages. These results were confirmed in an in vivo diabetic wound model. The DFO-laden hydrogels alleviated dysangiogenesis and chronic inflammation in the diabetic wounds, resulting in a more rapid wound healing and increased collagen deposition. Both in vitro and in vivo studies suggested potential clinical applications of these DFO-laden hydrogels in the treatment of diabetic ulcers.

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Section: Resultsmentioning

confidence: 99%

Section: Secretion Of Growthmentioning

confidence: 99%

Injectable Desferrioxamine-Laden Silk Nanofiber Hydrogels for Accelerating Diabetic Wound Healing

Ding

Zhang

Guo

et al. 2021

ACS Biomater. Sci. Eng.

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“…Nanoparticles (NPs) have good functionality, biocompatibility, and ability to target specific cells; thus, they are more likely to gain access into cytoplasm or nuclei due to their significantly larger surface-area-to-volume ratio. As a result, they offer an augmented response as well as different plausible physiochemical and biomedical characteristics from bigger particles [15]. NP production by physical or chemical synthetic methods needs expensive apparatus, reagents, and toxic solvents which lead to hazardous by-products, causing contamination to both the environment and biosystems [16].…”

Section: Introductionmentioning

confidence: 99%

Green Synthesis of Silver Nanoparticles by the Cyanobacteria Synechocystis sp.: Characterization, Antimicrobial and Diabetic Wound-Healing Actions

2022

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Green nanotechnology is now accepted as an environmentally friendly and cost-effective advance with various biomedical applications. The cyanobacterium Synechocystis sp. is a unicellular spherical cyanobacterium with photo- and hetero-trophic capabilities. This study investigates the ability of this cyanobacterial species to produce silver nanoparticles (AgNPs) and the wound-healing properties of the produced nanoparticles in diabetic animals. Methods: UV–visible and FT-IR spectroscopy and and electron microscopy techniques investigated AgNPs’ producibility by Synechocystis sp. when supplemented with silver ion source. The produced AgNPs were evaluated for their antimicrobial, anti-oxidative, anti-inflammatory, and diabetic wound healing along with their angiogenesis potential. Results: The cyanobacterium biosynthesized spherical AgNPs with a diameter range of 10 to 35 nm. The produced AgNPs exhibited wound-healing properties verified with increased contraction percentage, tensile strength and hydroxyproline level in incision diabetic wounded animals. AgNPs treatment decreased epithelialization period, amplified the wound closure percentage, and elevated collagen, hydroxyproline and hexosamine contents, which improved angiogenesis factors’ contents (HIF-1α, TGF-β1 and VEGF) in excision wound models. AgNPs intensified catalase (CAT), superoxide dismutase (SOD), and glutathione peroxidase (GPx) activities, and glutathione (GSH) and nitric oxide content and reduced malondialdehyde (MDA) level. IL-1β, IL-6, TNF-α, and NF-κB (the inflammatory mediators) were decreased with AgNPs’ topical application. Conclusion: Biosynthesized AgNPs via Synechocystis sp. exhibited antimicrobial, anti-oxidative, anti-inflammatory, and angiogenesis promoting effects in diabetic wounded animals.

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“…This suggests that the NPs encapsulating the therapeutic have a better healing outcome than the free therapeutic. 83 NPs made of peptides have also shown their utility in the field of wound healing. Elastin-like protein (ELP)-based fusion proteins, by forming NPs, have been shown to protect biomolecules from proteolysis and can act as ''drug depots'' that supply the biomolecules over an extended period.…”

Section: Nps As Drug Delivery Systemsmentioning

confidence: 99%

Nanotechnology Approaches in Chronic Wound Healing

Blanco-Fernandez

Castaño

Mateos‐Timoneda

et al. 2021

Advances in Wound Care

113

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The incidence of chronic wounds is increasing due to our aging population and the augment of people afflicted with diabetes. With the extended knowledge on the biological mechanisms underlying these diseases, there is a novel influx of medical technologies into the conventional wound care market. Recent Advances: Several nanotechnologies have been developed demonstrating unique characteristics that address specific problems related to wound repair mechanisms. In this review, we focus on the most recently developed nanotechnology-based therapeutic agents and evaluate the efficacy of each treatment in in vivo diabetic models of chronic wound healing. Critical Issues: Despite the development of potential biomaterials and nanotechnology-based applications for wound healing, this scientific knowledge is not translated into an increase of commercially available wound healing products containing nanomaterials. Future Directions: Further studies are critical to provide insights into how scientific evidences from nanotechnology-based therapies can be applied in the clinical setting.

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Lecithin-based deferoxamine nanoparticles accelerated cutaneous wound healing in diabetic rats

Cited by 19 publications

References 44 publications

Injectable Desferrioxamine-Laden Silk Nanofiber Hydrogels for Accelerating Diabetic Wound Healing

Injectable Desferrioxamine-Laden Silk Nanofiber Hydrogels for Accelerating Diabetic Wound Healing

Green Synthesis of Silver Nanoparticles by the Cyanobacteria Synechocystis sp.: Characterization, Antimicrobial and Diabetic Wound-Healing Actions

Nanotechnology Approaches in Chronic Wound Healing

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