Lecithin/sphingomyelin ratio in amniotic fluid obtained vaginally

Goldstein, Arnold S.; Mangurten, Henry H.; Libretti, Joseph V.; Berman, Arnold M.

doi:10.1016/0002-9378(80)90044-7

Cited by 8 publications

(4 citation statements)

References 2 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Amniotic fluid analysis has been used to study fetal lung maturity [7,16,21,27,28,30,55,85,88,91,93], karyotype, intra-amniotic inflammation, microorganisms (bacteria and viruses) [3,6,8,12,13,15,18,23,24,34,35,40,42–46,48,50,53,56–58,60–62,66–69,75,78–81,83,86,90,96,98,103,106] in patients with preterm prelabor rupture of membranes. Fluid obtained from the vaginal pool has been employed to assess fetal lung maturity [7,16,21,26–28,30,36,39,41,55,83,85,88,91–93,97].…”

Section: Discussionmentioning

confidence: 99%

“…Fluid obtained from the vaginal pool has been employed to assess fetal lung maturity [7,16,21,26–28,30,36,39,41,55,83,85,88,91–93,97]. However, this fluid cannot be used for the assessment of microbial invasion of the amniotic cavity or the assessment intra-amniotic inflammation, because bacteria are normally present in the vagina, and vaginal fluid contains a high concentration of inflammatory mediators [15,42,45,48,56–58,90,96].…”

Section: Discussionmentioning

confidence: 99%

“…Amniotic fluid analysis is used to assess the likelihood of intra-amniotic infection, intra-amniotic inflammation [3,6,8,12,13,15,18,23,24,34,35,40,42–46,48,50,53,56–58,60–62,66–69,75,78–81,83,86,90,96,98,103,106] and fetal lung maturity [7,16,21,26,27,30,36,39,41,55,83,85,88,91–93,97] in preterm PROM. Amniotic fluid can be retrieved with amniocentesis; however, this procedure is technically demanding in the context of rupture of membranes due to the decreased volume of amniotic fluid frequently observed in these cases [5,71,102].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

A transcervical amniotic fluid collector: a new medical device for the assessment of amniotic fluid in patients with ruptured membranes

Lee¹,

Romero²,

Park

et al. 2014

Journal of Perinatal Medicine

View full text Add to dashboard Cite

Aim To describe a new device for the transcervical collection of amniotic fluid (AF) in patients with ruptured membranes, and to compare the concentration of proteins in fluid retrieved by transabdominal amniocentesis and the transcervical AF collector. Study Design Paired AF samples were collected in patients with preterm prelabor rupture of membrane (PROM) (n=11) by transabdominal amniocentesis and with the transcervical AF collector. Three proteins known to have high concentrations in AF [alpha-fetoprotein (AFP), β-human chorionic gonadotrophin (β-hCG), and prolactin] were measured. Results 1) There was a significant correlation between the concentrations of analytes in AF obtained by transabdominal amniocentesis and by the transcervical AF collector (r=0.95, p<0.001 for AFP; r=0.95, p<0.001 for β -hCG; r=0.84, p<0.005 for prolactin); 2) Bland-Altman plots showed no evidence of heteroscedasticity between transabdominal and transcervical AF concentrations of these markers. Conclusions There was a strong correlation between the concentrations of proteins in AF collected by amniocentesis or with the transcervical device.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

A transcervical amniotic fluid collector: a new medical device for the assessment of amniotic fluid in patients with ruptured membranes

Lee¹,

Romero²,

Park

et al. 2014

Journal of Perinatal Medicine

View full text Add to dashboard Cite

show abstract

“…This problem was attributed to the oligohydramnios usually present in cases of PROM, and has been described by other authors [6,32]. As a result of the difficulty encountered in obtaining amniotic fluid via amniocentesis, from 1980, various investigators have studied amniotic fluid collected from the vagina [1,3,7,15,16,17,21,23,26,27,30,31]. The most reliable indicator of fetal lung maturity in amniotic fluid recovered from the vagina, is the presence of phosphatidylglycerol (PhG) [3,26,31].…”

Section: Introductionmentioning

confidence: 90%

Phosphatidylglycerol determination in the amniotic fluid from a PAD placed over the vulva: a method for diagnosis of fetal lung maturity in cases of premature ruptured membranes

Estol

Poseiro²,

Schwarcz³

1992

Jpme

View full text Add to dashboard Cite

Four hundred and forty seven pregnant women with ruptured membranes, were prospectively studied in order to assess the diagnostic capacity of Phosphatidylglycerol (PhG) determination in amniotic fluid recovered from vulval pads in the diagnosis of Hyaline Membrane Disease (HMD). The identification of PhG was performed using one dimensional silica gel thin layer chromatography. The sensitivity of PhG determination in the diagnosis of HMD in newborns of the total population was found to be 88.2%, with a specificity of 76.9%. In the study population, the incidence of HMD was 7.6%, the negative predictive value was 98.8% and, the positive predictive value was 24.0%. When the 265 newborns of the gestational age group of less than or equal to 34 weeks is considered, we observed an incidence of HMD of 12.1%. The diagnostic capacity of PhG in this group was shown by a sensitivity of 87.5%, a specificity of 76.4%, a positive predictive value of 33.7% and a negative predictive value of 97.8%. This method of assessment of fetal lung maturity has a diagnostic capability similar to that described by other authors, who used amniotic fluid obtained vaginally or transabdominally. The procedure described here of amniotic fluid collection is non-invasive, harmless to the mother and fetus and simple to perform. The characteristics of this method, allow serial studies of the amniotic fluid to be carried out.

show abstract

Preterm Labor

and

Myles

2007

Clinical Obstetrics

View full text Add to dashboard Cite

Lecithin/sphingomyelin ratio in amniotic fluid obtained vaginally

Cited by 8 publications

References 2 publications

A transcervical amniotic fluid collector: a new medical device for the assessment of amniotic fluid in patients with ruptured membranes

A transcervical amniotic fluid collector: a new medical device for the assessment of amniotic fluid in patients with ruptured membranes

Phosphatidylglycerol determination in the amniotic fluid from a PAD placed over the vulva: a method for diagnosis of fetal lung maturity in cases of premature ruptured membranes

Preterm Labor

Contact Info

Product

Resources

About