LECT2 improves the outcomes in ayu with Vibrio anguillarum infection via monocytes/macrophages

Chen, Jiong; Chen, Qiang; Lu, Xin-Jiang; Li, Changhong

doi:10.1016/j.fsi.2014.10.012

Cited by 37 publications

(18 citation statements)

References 42 publications

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“…L. anguillarum is the main pathogen of ayu47. In our previous study, we demonstrated an important role for monocytes/macrophages against L. anguillarum 47. In the present study, we also found that LPS HSPCs exhibited fewer numbers of monocytes/macrophages and neutrophils after transplantation.…”

Section: Discussionsupporting

confidence: 80%

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Mobilisation and dysfunction of haematopoietic stem/progenitor cells after Listonella anguillarum infection in ayu, Plecoglossus altivelis

Chen

Rong

et al. 2016

Sci Rep

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Haematopoietic stem/progenitor cells (HSPCs) can mobilise into blood and produce immune cell lineages following stress. However, the homeostasis and function of HSPCs after infection in teleosts are less well known. Here, we report that Listonella anguillarum infection enhances HSPC mobilisation and reduces their differentiation into myeloid cells in ayu (Plecoglossus altivelis), an aquacultured teleost in East Asia. We established a colony-forming unit culture (CFU-C) assay to measure HSPCs using conditioned medium from peripheral blood mononuclear cells stimulated with phytohaemagglutinin. The number of CFU-Cs decreased in the head kidney and increased in the blood and spleen of ayu infected with L. anguillarum. HSPC mobilisation after L. anguillarum infection was mediated by norepinephrine. Furthermore, HSPCs from ayu treated with L. anguillarum lipopolysaccharide (LPS) showed defective myeloid differentiation and could no longer rescue L. anguillarum-infected ayu. HSPC expansion was suppressed after L. anguillarum infection or its LPS treatment in vitro. These results reveal a link between HSPC regulation and pathogen infection in teleosts.

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Section: Discussionsupporting

confidence: 80%

“…Hence, the deficiency of HSPCs from infected animals may be attributed to infection and pathogenesis. L. anguillarum is the main pathogen of ayu47. In our previous study, we demonstrated an important role for monocytes/macrophages against L. anguillarum 47.…”

Section: Discussionmentioning

confidence: 86%

Mobilisation and dysfunction of haematopoietic stem/progenitor cells after Listonella anguillarum infection in ayu, Plecoglossus altivelis

Chen

Rong

et al. 2016

Sci Rep

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“…mRNA levels of IL-1β and TNF-α genes are down-regulated in rainbow trout after infection with Aeromonas salmonicida [48]. Bacterial or LPS challenges result in significantly increased transcripts levels of IL-10 in teleost head kidneys [49, 50]. In our study, IL-10 and TGFβ transcript expression levels was enhanced in E .…”

Section: Discussionmentioning

confidence: 53%

Molecular characterization of mudskipper (Boleophthalmus pectinirostris) hypoxia-inducible factor-1α (HIF-1α) and analysis of its function in monocytes/macrophages

Guan

et al. 2017

PLoS ONE

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Hypoxia-inducible factor-1α (HIF-1α) plays a critical role in immune and inflammatory responses and is important in controlling a variety of processes in monocytes and macrophages. However, very little information is available about the functions of HIF-1α in fish monocytes/macrophages (MO/MФ). In this study, the cDNA sequence of the mudskipper (Boleophthalmus pectinirostris) HIF-1α gene (BpHIF-1α) was determined. Sequence comparison and phylogenetic tree analysis showed that BpHIF-1α is clustered in the fish HIF-1α tree. Constitutive expression of BpHIF-1α mRNA was detected by real-time quantitative PCR in all tested tissues, and the expression was found to be dramatically increased in the skin, liver, spleen, and kidney after Edwardsiella tarda infection. In addition, hypoxia and infection induced the expression of the BpHIF-1α transcript and protein in MO/MФ, respectively. Hypoxia caused an increase in phagocytic and bactericidal capacity of mudskipper MO/MФ in a BpHIF-1α-dependent manner. BpHIF-1α induced an anti-inflammatory status in MO/MФ upon E. tarda infection and hypoxia. Therefore, BpHIF-1α may play a predominant role in the modulation of mudskipper MO/MФ function in the innate immune system.

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“…) and chemotaxin 2 (LECT2) and PaCXCL8l (Chen et al . ). Immunostimulants can trigger enhanced monocyte activity.…”

Section: Immunostimulatory Effects On Monocytesmentioning

confidence: 97%

Influences of immunostimulants on phagocytes in cultured fish: a mini review

Abarike

Kuebutornye

Jian

et al. 2018

Reviews in Aquaculture

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Lower vertebrates like fish mostly depend on innate immunity as the first line of defence against invading pathogens. One of the defence mechanisms in innate immunity for fish is the use of phagocytic cells such as monocytes, macrophages, neutrophils, mast cells and dendritic cells in fighting pathogens. These cellular cells employ a variety of mechanisms in protecting fish including but not limited to; the use of pattern recognition receptors and antigen presenting cells to detect the presence of pathogens in host, neutralising them using measures including; inflammation, production of lysosomal enzymes released into the phagosome to neutralising pathogens and prevention of systemic autoimmunity by apoptosis. Some phagocytic cells play the extra role of serving as a bridge between innate and adaptive immunity in fish. Recent accumulating data showed that phagocyte cell activity in fish could be enhanced by a natural or chemical substance (immunostimulants) that stimulates the immune system in fish principally meant to enhance the immune response mechanisms. In this review, the main focus is on elucidating the distinct phagocytic mechanisms played by monocytes, macrophages, neutrophils, mast cells and dendritic cells as principal phagocytes in immune defence and how their activities are influenced by immunostimulants in cultured fish.

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LECT2 improves the outcomes in ayu with Vibrio anguillarum infection via monocytes/macrophages

Cited by 37 publications

References 42 publications

Mobilisation and dysfunction of haematopoietic stem/progenitor cells after Listonella anguillarum infection in ayu, Plecoglossus altivelis

Mobilisation and dysfunction of haematopoietic stem/progenitor cells after Listonella anguillarum infection in ayu, Plecoglossus altivelis

Molecular characterization of mudskipper (Boleophthalmus pectinirostris) hypoxia-inducible factor-1α (HIF-1α) and analysis of its function in monocytes/macrophages

Influences of immunostimulants on phagocytes in cultured fish: a mini review

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