Lectin from red algae Amansia multifida Lamouroux: Extraction, characterization and anti-inflammatory activity

Mesquita, Jacilane Ximenes; Brito, Tarcísio Vieira de; Fontenelle, Thais Pontes Carvalho; Damasceno, Renan Oliveira Silva; Souza, Marcellus H.; Lopes, José Luiz de Souza; Beltramini, Leila Maria; Barbosa, André Luiz dos Reis; Freitas, Ana Lúcia Ponte

doi:10.1016/j.ijbiomac.2020.12.203

Cited by 20 publications

(9 citation statements)

References 24 publications

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“…Recently, bioactive peptides with therapeutic and anti-inflammatory effects have attracted particular attention (Lee et al 2015). In addition, it has shown great therapeutic potential in the lectin of red seaweed, which has anti-inflammatory, hypoglycemic and antioxidant effects (Alves et al 2020;Mesquita et al 2021). Furthermore, red seaweed contains numerous glycine, arginine, alanine, and glutamic acids, including mycosporine-like amino acids, which have been demonstrated to provide UV protection and antioxidant characteristics (De et al 2009;Karsten et al 1998;Sun et al 2020).…”

Section: Red Seaweedsmentioning

confidence: 99%

Global seaweed farming and processing in the past 20 years

Zhang

Liao

Huang

et al. 2022

Food Prod Process and Nutr

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Seaweed has emerged as one of the most promising resources due to its remarkable adaptability, short development period, and resource sustainability. It is an effective breakthrough to alleviate future resource crises. Algal resources have reached a high stage of growth in the past years due to the increased output and demand for seaweed worldwide. Several aspects global seaweed farming production and processing over the last 20 years are reviewed, such as the latest situation and approaches of seaweed farming. Research progress and production trend of various seaweed application are discussed. Besides, the challenges faced by seaweed farming and processing are also analyzed, and the related countermeasures are proposed, which can provide advice for seaweed farming and processing. The primary products, extraction and application, or waste utilization of seaweed would bring greater benefits with the continuous development and improvement of applications in various fields. Graphical Abstract

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Section: Red Seaweedsmentioning

confidence: 99%

Global seaweed farming and processing in the past 20 years

Zhang

Liao

Huang

et al. 2022

Food Prod Process and Nutr

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“…Reduction in TNF-α, IL-1β levels, and neutrophil migration. Increased glutathione levels [ 87 ] Eucheuma cottonii Lectin-rich extract In vivo, anti-inflammatory Decreased mucin synthesis, leucocyte infiltration, and TNF-α, NF-κB, IL-4, MMP-9, EGFR levels in asthmatic rats [ 88 ] Briothamniun triquetum Lectin In vivo, anti-inflammatory Reduced peritonitis and paw edema in treated mice. Reduction in TNF-α, IL-1β, MPO levels, and neutrophil migration.…”

Section: Bioactive Properties and Mechanisms Of Actionmentioning

confidence: 99%

“…However, when directly injected into rat paws instead of intravenously, the lectin induced a strong inflammatory response, which is related to the absent interaction with pro-inflammatory agents but also to the administration route [ 27 ]. A 30 kDa lectin purified from Amansia multifida displayed similar effects, modulating paw edema and peritonitis formation in mice [ 87 ]. This lectin consistently ameliorated paw edema against carrageenan, histamine, prostaglandin E2, and compound 48/80 (an inducer of histamine release).…”

Section: Bioactive Properties and Mechanisms Of Actionmentioning

confidence: 99%

“…Moreover, its administration showed lower MPO activity, with values even lower than those observed for indomethacin. Its anti-inflammatory effect was also confirmed by the increased levels of glutathione, which were greater than in the control group, thus indicating that its anti-inflammatory property is also related to preventing further oxidative damage [ 87 ].…”

Section: Bioactive Properties and Mechanisms Of Actionmentioning

confidence: 99%

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Seaweed-Derived Proteins and Peptides: Promising Marine Bioactives

et al. 2022

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Seaweeds are a typical food of East-Asian cuisine, to which are alleged several beneficial health effects have been attributed. Their availability and their nutritional and chemical composition have favored the increase in its consumption worldwide, as well as a focus of research due to their bioactive properties. In this regard, seaweed proteins are nutritionally valuable and comprise several specific enzymes, glycoproteins, cell wall-attached proteins, red algae phycobiliproteins, lectins, peptides, or mycosporine-like amino acids. This great extent of molecules has been reported to exert significant antioxidant, antimicrobial, anti-inflammatory, antihypertensive, antidiabetic, or antitumoral properties. Hence, knowledge on algae proteins and derived compounds have gained special interest for the potential nutraceutical, cosmetic or pharmaceutical industries based on these bioactivities. Although several molecular mechanisms of action on how these proteins and peptides exert biological activities have been described, many gaps in knowledge still need to be filled. Updating the current knowledge related to seaweed proteins and peptides is of interest to further asses their potential health benefits. This review addresses the characteristics of seaweed protein and protein-derived molecules, their natural occurrence, their studied bioactive properties, and their described potential mechanisms of action.

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“…The final highlight of the results in Table 2 should be given to a relevant number of studies that were condcted in vivo using mice and rats. Most of the reports described the reduction of paw oedema [115,121,126,141,157,[162][163][164][165][166][167] and reduced leukocyte influx/migration [168], or even both [116,[122][123][124][125]169,170], proving that red seaweed-derived compounds are effectively anti-inflammatory. Though a significant number of compounds isolated from Rhodophyta have proven to be anti-inflammatory, both in vitro and in vivo, the opportunity to investigate how these compounds behave in individuals suffering from AV remains open.…”

Section: Anti-inflammatory Extracts and Compounds From Red Macroalgaementioning

confidence: 99%

Red Seaweed-Derived Compounds as a Potential New Approach for Acne Vulgaris Care

Januário

Félix

et al. 2021

Pharmaceutics

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Acne vulgaris (AV) is a chronic skin disease of the pilosebaceous unit affecting both adolescents and adults. Its pathophysiology includes processes of inflammation, increased keratinization, sebum production, hormonal dysregulation, and bacterial Cutibacterium acnes proliferation. Common AV has been treated with antibiotics since the 1960s, but strain resistance has emerged and is of paramount concern. Macroalgae are known producers of substances with bioactive properties, including anti-viral, antibacterial, antioxidant, and anti-inflammatory properties, among several others. In particular, red algae are rich in bioactive compounds such as polysaccharides, phenolic compounds, lipids, sterols, alkaloids, and terpenoids, conferring them antioxidant, antimicrobial, and anti-inflammatory activities, among others. Thus, the exploration of compounds from marine resources can be an appealing approach to discover new treatment options against AV. The aim of this work is to provide an overview of the current knowledge of the potentialities of red macroalgae in the treatment of AV by reviewing the main therapeutic targets of this disease, and then the existence of compounds or extracts with bioactive properties against them.

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Lectin from red algae Amansia multifida Lamouroux: Extraction, characterization and anti-inflammatory activity

Cited by 20 publications

References 24 publications

Global seaweed farming and processing in the past 20 years

Global seaweed farming and processing in the past 20 years

Seaweed-Derived Proteins and Peptides: Promising Marine Bioactives

Red Seaweed-Derived Compounds as a Potential New Approach for Acne Vulgaris Care

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