LED fluorescence spectroscopy for direct determination of monoamine oxidase B inactivation

Castillo, Jimmy; Hung, J.; Rodríguez, Mario; Bastidas, Elsy; Laboren, I.; Jaimes, A.

doi:10.1016/j.ab.2005.05.027

Cited by 35 publications

(15 citation statements)

References 17 publications

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“…This activity was confirmed in a recent study published in 2003 (71). In the mitochondria, berberine was shown to inhibit monoamine oxidase directly (72)(73)(74). The mitochondrial inhibition was demonstrated in living cells in our recent study (53).…”

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confidence: 81%

Traditional Chinese Medicine in Treatment of Metabolic Syndrome

Yin¹,

Zhang²,

Ye³

2008

EMIDDT

338

220

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In management of metabolic syndrome, the traditional Chinese medicine (TCM) is an excellent representative in alternative and complementary medicines with a complete theory system and substantial herb remedies. In this article, basic principle of TCM is introduced and 22 traditional Chinese herbs are reviewed for their potential activities in the treatment of metabolic syndrome. Three herbs, ginseng, rhizoma coptidis (berberine, the major active compound) and bitter melon, were discussed in detail on their therapeutic potentials. Ginseng extracts made from root, rootlet, berry and leaf of Panax quinquefolium (American ginseng) and Panax ginseng (Asian ginseng), are proved for anti-hyperglycemia, insulin sensitization, islet protection, anti-obesity and anti-oxidation in many model systems. Energy expenditure is enhanced by ginseng through thermogenesis. Ginseng-specific saponins (ginsenosides) are considered as the major bioactive compounds for the metabolic activities of ginseng. Berberine from rhizoma coptidis is an oral hypoglycemic agent. It also has anti-obesity and anti-dyslipidemia activities. The action mechanism is related to inhibition of mitochondrial function, stimulation of glycolysis, activation of AMPK pathway, suppression of adipogenesis and induction of low-density lipoprotein (LDL) receptor expression. Bitter melon or bitter gourd (Momordica charantia) is able to reduce blood glucose and lipids in both normal and diabetic animals. It may also protect β cells, enhance insulin sensitivity and reduce oxidative stress. Although evidence from animals and humans consistently supports the therapeutic activities of ginseng, berberine and bitter melon, multi-center large-scale clinical trials have not been conducted to evaluate the efficacy and safety of these herbal medicines.Metabolic syndrome characterized by insulin resistance has become a health thread worldwide in the past 20 years (1). In survey of 8,814 people in USA, prevalence of metabolic syndrome was over 40% in people of 60-69 year old (2). In the other geographic areas in the world including Europe and Asia, the prevalence of metabolic syndrome has been increasing dramatically (1). Metabolic syndrome and associated diseases have been one of major burdens in health care system in many industrialized countries.The concept of metabolic syndrome was generated by Kylin in 1923, who described a cluster of medical conditions, such as hypertension, hyperglycemia and gout (3). The concept did not attract much attention until Dr. Gerald Reaven introduced the syndrome X in 1988 (4), which is similar to the metabolic syndrome. In 1999, WHO (World Health Organization) and EGIR (European Group for the Study of Insulin Resistance) released their diagnostic criteria for the metabolic syndrome, respectively (5;6). Now, there are at least 6 sets of diagnostic criteria for the syndrome from different organizations over the world (1;7). The primary contents of diagnostic criteria are similar among these organizations. They are hyperglycemia, insulin r...

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confidence: 81%

Traditional Chinese Medicine in Treatment of Metabolic Syndrome

Yin¹,

Zhang²,

Ye³

2008

EMIDDT

338

220

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“…Berberine acts as a reversible competitive inhibitor of acetylcholinesterase in a dose-dependent manner (IC 50 = 3.3 μM) Whiteley and Daya, 1995), inhibits tyrosine hydroxylase leading to decreased dopamine content in PC12 cells (IC 50 = 18.6 μM) (Shin et al, 2000), inhibits tryptophan hydroxylase, a ratelimiting enzyme in serotonin biosynthesis (Lee et al, 2001), inhibits lens aldose reductase (IC 50 = 13.98 nM) (Lee, 2002) and competitively inhibits MAO-A (IC 50 = 126 μM) (Kong et al, 2001) and MAO-B (IC 50 = 90 μM) (Castillo et al, 2005).…”

Section: Central Nervous System Effectsmentioning

confidence: 99%

Pharmacological and therapeutic effects of Berberis vulgaris and its active constituent, berberine

Imanshahidi

Hosseinzadeh

2008

Phytotherapy Research

543

321

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Barberry (Berberis vulgaris L. family Berberidaceae) is well known in Iran and various parts of this plant including its root, bark, leaf and fruit have been used as folk medicine. The two decades of research has demonstrated different pharmacological and therapeutic effects of B. vulgaris and its isoquinoline alkaloids (particularly berberine). Studies carried out on the chemical composition of the plant show that the most important constituents of this plant are isoquinoline alkaloids such as berberine, berbamine and palmatine. Berberine represents one of the most studied among the naturally occurring protoberberine alkaloids. In addition to B. vulgaris (barberry), berberine is present in many other plants and is used for the treatment of different diseases. This article reviews the traditional uses and pharmacological effects of total extract and the most active ingredient of B. vulgaris (berberine).

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“…Due to its multi-faceted nature, BBR has been shown to address several of those imbalances in a positive way. These activities include cholesterol reduction, ERK pathway activation, inhibition of MAO-B activity, defense against damage from reactive oxygen species (ROS), inhibition of acetylcholinesterase (AChE), butyrylcholinesterase (BChE) activity, and beta-secretase, and reduction in the amyloid-beta genesis [ 3 , 23 – 26 ]. This has led to an overall reduction in amyloid plaque aggregation and reduction in phenotypic pathology of AD in the mouse model [ 27 ].…”

Section: The Therapeutic Effect Of Bbr On Admentioning

confidence: 99%

Therapeutic potential of berberine against neurodegenerative diseases

Jiang

2015

Sci. China Life Sci.

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Berberine (BBR) is an organic small molecule isolated from various plants that have been used in traditional Chinese medicine. Isolation of this compound was its induction into modern medicine, and its usefulness became quickly apparent as seen in its ability to combat bacterial diarrhea, type 2 diabetes, hypercholesterolemia, inflammation, heart diseases, and more. However, BBR’s effects on neurodegenerative diseases remained relatively unexplored until its ability to stunt Alzheimer’s disease (AD) progression was characterized. In this review, we will delve into the multi-faceted defensive capabilities and bio-molecular pathways of BBR against AD, Parkinson’s disease (PD), and trauma-induced neurodegeneration. The multiple effects of BBR, some of which enhance neuro-protective factors/pathways and others counteract targets that induce neurodegeneration, suggest that there are many more branches to the diverse capabilities of BBR that have yet to be uncovered. The promising results seen provide a convincing and substantial basis to support further scientific exploration and development of the therapeutic potential of BBR against neurodegenerative diseases.

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LED fluorescence spectroscopy for direct determination of monoamine oxidase B inactivation

Cited by 35 publications

References 17 publications

Traditional Chinese Medicine in Treatment of Metabolic Syndrome

Traditional Chinese Medicine in Treatment of Metabolic Syndrome

Pharmacological and therapeutic effects of Berberis vulgaris and its active constituent, berberine

Therapeutic potential of berberine against neurodegenerative diseases

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