Left Atrial Sphericity: A New Method to Assess Atrial Remodeling. Impact on the Outcome of Atrial Fibrillation Ablation

Bisbal, Felipe; Guiu, Esther; Calvo, Naiara; Marín, David; Berruezo, Antonio; Arbelo, Elena; Ortiz-Pérez, Josè T.; Caralt, Teresa M. de; Tolosana, José Marı́a; Borràs, Roger; Sitges, Marta; Brugada, Josep; Mont, Lluı́s

doi:10.1111/jce.12116

Cited by 136 publications

(192 citation statements)

References 36 publications

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“…This is despite the limitation of using a solitary linear measurement to characterize a three-dimensional shape [22]. Furthermore, recent data suggest that atrial remodeling not only leads to enlargement but also distinct symmetry changes as well [21,23,24]. Recently, it has been demonstrated that LA size-, morphology-, and volume are better predictors of AF recurrence after LA ablation than anterior-posterior LA diameter measurements [23][24][25].…”

Section: Prediction Of Pulmonary Vein Isolation Successmentioning

confidence: 92%

State-of-the-Art CT Imaging of the Left Atrium

Karády

Whitaker²,

Rajani³

et al. 2016

Curr Radiol Rep

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Purpose of the Review Cardiac computed tomography (CT) angiography with its high spatial and temporal resolution is a robust anatomical imaging tool. Beyond coronary artery examination in suspected coronary artery disease, cardiac CT is a helpful modality to depict cardiac morphology in surgical and percutaneous structural interventions planning. Conditions related to the left atrium are diverse; therefore, the importance of CT imaging is becoming more frequent. Recent Findings Latest technological advancements allow for low radiation dose image acquisition along with improved image quality detailed visualization of the left atrium during interventional procedure planning. In addition, left atrial imaging provides additional information regarding stroke risk, cardiovascular outcomes, congestive heart failure, and arrhythmia mechanisms. Therefore, the left atrium has been proposed as a barometer of cardiac function and cardiovascular risk.Summary Cardiac CT has become an indispensable tool in the electrophysiology laboratory in the guidance of complex procedures, including trans-catheter pulmonary vein isolation in the treatment of drug-refractory atrial fibrillation. The detailed visualization of left atrial morphology and pulmonary vein anatomy is frequently helpful in achieving therapeutic success and avoiding complications.

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Section: Prediction Of Pulmonary Vein Isolation Successmentioning

confidence: 92%

State-of-the-Art CT Imaging of the Left Atrium

Karády

Whitaker²,

Rajani³

et al. 2016

Curr Radiol Rep

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“…The original motivation was to obtain a smooth parametrizations from a triangulations of star-shaped surfaces in R 3 representing the left atrium of the heart of a sample of patients with atrial fibrillation, see [2].…”

Section: Introductionmentioning

confidence: 99%

A Priori L 2-Error Estimates for Approximations of Functions on Compact Manifolds

Marín

Nicolau

2014

Mediterr. J. Math.

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“…The trans-axial images were acquired with a slice thickness of 0. 5 and reconstructed with a voxel size of 0.5 × 0.4 × 0.4 3 . The protocol of this study was approved by the local research ethics committee.…”

Section: Data Preparationmentioning

confidence: 99%

“…Previous studies reported that hypertension, Holter duration, left atrial (LA) volume and LA sphericity [2,3,4,5] were potentially related to post-ablation recurrence, but their underlying mechanism is still unclear, as is LA remodeling in AF.…”

Section: Introductionmentioning

confidence: 99%

Prediction of Post-Ablation Outcome in Atrial Fibrillation Using Shape Parameterization and Partial Least Squares Regression

Jia

Camaioni

Rohé

et al. 2017

Functional Imaging and Modelling of the Heart

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Abstract.To analyze left atrial remodeling may reveal shape features related to post-ablation outcome in atrial fibrillation, which helps in identifying suitable candidates before ablation. In this article, we propose an application of diffeomorphometry and partial least squares regression to address this problem. We computed a template of left atrial shape in control group and then encoded the shapes in atrial fibrillation with a large set of parameters representing their diffeomorphic deformation. We applied a two-step partial least squares regression. The first step eliminates the influence of atrial volume in shape parameters. The second step links deformations directly to post-ablation recurrence and derives a few principle modes of deformation, which are unrelated to volume change but are involved in post-ablation recurrence. These modes contain information on ablation success due to shape differences, resulting from remodeling or influencing ablation procedure. Some details are consistent with the most complex area of ablation in clinical practice. Finally, we compared our method against the left atrial volume index by quantifying the risk of post-ablation recurrence within six months. Our results show that we get better prediction capabilities (area under receiver operating characteristic curves = 0.73) than left atrial dilation ( = 0.47), which outperforms the current state of the art.

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Left Atrial Sphericity: A New Method to Assess Atrial Remodeling. Impact on the Outcome of Atrial Fibrillation Ablation

Abstract: Left Atrial Sphericity is a new independent predictor of recurrence after AF ablation and may be useful in selecting the best candidates for AF ablation.

Cited by 136 publications

References 36 publications

State-of-the-Art CT Imaging of the Left Atrium

State-of-the-Art CT Imaging of the Left Atrium

A Priori L 2-Error Estimates for Approximations of Functions on Compact Manifolds

Prediction of Post-Ablation Outcome in Atrial Fibrillation Using Shape Parameterization and Partial Least Squares Regression

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