Left frontal aslant tract and lexical selection: Evidence from frontal lobe lesions

Zyryanov, Andrey; Malyutina, Svetlana; Dragoy, Olga

doi:10.1016/j.neuropsychologia.2020.107385

Cited by 11 publications

(13 citation statements)

References 66 publications

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“…At the most stringent statistical threshold (FWE correction at α = 0.05), both versions of the paradigm elicited significant activation in the left posterior inferior and posterior superior frontal gyri (differences in results with the SYLL and PW baseline are discussed in section “Comparison of baseline conditions”). The left IFG has been implicated in many linguistic processes engaged by the sentence completion task: sentence parsing ( Hagoort, 2005 ), conceptual and lexical selection of the completing word ( Robinson et al, 2010 ; Zyryanov et al, 2020 ), morphosyntactic inflection of the completing word ( Den Ouden et al, 2019 ), and articulatory encoding ( Flinker et al, 2015 ). Such multifaceted involvement of the left IFG in linguistic processes may explain why its activation was the most statistically robust.…”

Section: Discussionmentioning

confidence: 99%

“…These ROIs were chosen theoretically as the most relevant for the sentence completion task. The IFG is implicated in numerous linguistic functions including morphosyntactic processing ( Hagoort, 2005 ; Den Ouden et al, 2019 ), lexical selection ( Zyryanov et al, 2020 ) and articulatory encoding ( Flinker et al, 2015 ). pMFG has been recently discussed as crucial for speech fluency ( Hazem et al, 2021 ).…”

Section: Methodsmentioning

confidence: 99%

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A New Functional Magnetic Resonance Imaging Localizer for Preoperative Language Mapping Using a Sentence Completion Task: Validity, Choice of Baseline Condition, and Test–Retest Reliability

Elin¹,

Malyutina²,

Бронов

et al. 2022

Front. Hum. Neurosci.

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To avoid post-neurosurgical language deficits, intraoperative mapping of the language function in the brain can be complemented with preoperative mapping with functional magnetic resonance imaging (fMRI). The validity of an fMRI “language localizer” paradigm crucially depends on the choice of an optimal language task and baseline condition. This study presents a new fMRI “language localizer” in Russian using overt sentence completion, a task that comprehensively engages the language function by involving both production and comprehension at the word and sentence level. The paradigm was validated in 18 neurologically healthy volunteers who participated in two scanning sessions, for estimating test–retest reliability. For the first time, two baseline conditions for the sentence completion task were compared. At the group level, the paradigm significantly activated both anterior and posterior language-related regions. Individual-level analysis showed that activation was elicited most consistently in the inferior frontal regions, followed by posterior temporal regions and the angular gyrus. Test–retest reliability of activation location, as measured by Dice coefficients, was moderate and thus comparable to previous studies. Test–retest reliability was higher in the frontal than temporo-parietal region and with the most liberal statistical thresholding compared to two more conservative thresholding methods. Lateralization indices were expectedly left-hemispheric, with greater lateralization in the frontal than temporo-parietal region, and showed moderate test-retest reliability. Finally, the pseudoword baseline elicited more extensive and more reliable activation, although the syllable baseline appears more feasible for future clinical use. Overall, the study demonstrated the validity and reliability of the sentence completion task for mapping the language function in the brain. The paradigm needs further validation in a clinical sample of neurosurgical patients. Additionally, the study contributes to general evidence on test–retest reliability of fMRI.

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

A New Functional Magnetic Resonance Imaging Localizer for Preoperative Language Mapping Using a Sentence Completion Task: Validity, Choice of Baseline Condition, and Test–Retest Reliability

Elin¹,

Malyutina²,

Бронов

et al. 2022

Front. Hum. Neurosci.

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“…Currently, we are using the method to explore the neural substrates of different aphasia types, bringing Luria's classification of aphasias into the contemporary neuroscience context (Luria, 1980). Another technique that we have adopted involves diffusion-weighted imaging and tractography analyses (e.g., Ivanova et al, 2016;Zyryanov et al, 2020). These methods allow to investigate the integrity of white-matter fiber pathways in the brain and determine their functional specialization.…”

Section: Research Advancementsmentioning

confidence: 99%

“…This has carried inherent risks for the supervisor in case the student fails to complete the assigned part of the project. Nevertheless, this practice has also brought amazing successes, whereby undergraduate students became the driving force of research projects and played an essential role in their successful completion (e.g., Soloukhina and Ivanova, 2018;Zyryanov et al, 2020;Savinova and Malyutina, 2021). Several of the students who completed their "course research projects" or bachelor's theses at the Center later went to study abroad to obtain their master's degree or PhD and then returned to work at the Center as research scientists.…”

Section: Teaching and Supervisionmentioning

confidence: 99%

Advancing Neurolinguistics in Russia: Experience and Implications of Building Experimental Research and Evidence-Based Practices

Ivanova¹,

Malyutina²,

Dragoy

2021

Front. Psychol.

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Russia has rich theoretical and behavioral research traditions in neurolinguistics and neuropsychology, but at the beginning of the twenty-first century contemporary experimental research in these disciplines remained limited, leading to proliferation of non-evidence-based approaches in education, healthcare, and public beliefs. An academic response to this was the establishment of the Center for Language and Brain at the HSE University, Moscow, which focused on experimental psycho- and neurolinguistic research and related evidence-based practices. The Center has grown from a small group of young researchers to a large interdisciplinary unit that conducts cutting-edge research utilizing multi-site settings and novel structural and functional neuroimaging methods. The overarching aim of the Center's research is to promote scientifically grounded treatment of the language-brain relationship in the educational, clinical, and industry settings. Specifically, translational research at the Center is contributing to the advancement of clinical practice in Russia: from providing the first standardized aphasia language test to implementing protocols for intraoperative language mapping in neurosurgery departments across the country. Within research projects, a new generation of scientists is successfully being fostered, while a broader student audience is reached via courses taught by staff of the Center to students of different majors. Notable examples of public outreach programs at the Center are the Annual Summer Neurolinguistics School attracting hundreds of attendees from different countries each year, and community projects focused on raising awareness about aphasia. Together, these efforts aim to increase scientific knowledge in a multi-professional audience. In this paper, we will share our joint experiences in establishing, building, and promoting a neurolinguistics research center in Russia and the impact that this work has had on the broader public. We will delineate specific milestones of this journey and focus on the main pillars that have contributed to our progress: research, clinical work, teaching, and public outreach programs. We hope that this critical appraisal of our experiences can serve simultaneously as an inspiration and a practical guide for other groups developing research, clinical, and educational programs in different neuroscientific disciplines across the globe and aiming to improve the quality of the neuroscientific information available to the public.

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“…At the most stringent statistical threshold (FWE correction at α = .05), both versions of the paradigm elicited significant activation in the left posterior inferior and posterior superior frontal gyri (differences in results with the SYLL and PW baseline are discussed in Section 4.4). The left posterior inferior frontal gyrus has been implicated in many linguistic processes engaged by the sentence completion task: sentence parsing (Hagoort et al, 2005), conceptual and lexical selection of the completing word (Robinson et al, 2010;Zyryanov et al, 2020), morphosyntactic inflection of the completing word (Den Ouden et al, 2019), and articulatory encoding (Flinker et al, 2007). Such multifaceted involvement of the left inferior frontal gyrus in linguistic processes may explain why its activation was the most statistically robust.…”

Section: Activation Of Key Language-related Areasmentioning

confidence: 99%

A new fMRI localizer for preoperative language mapping using a sentence completion task: Validity, choice of baseline condition, and test-retest reliability

Elin¹,

Malyutina²,

Бронов

et al. 2021

Preprint

Self Cite

View full text Add to dashboard Cite

To avoid post-neurosurgical language deficits, intraoperative mapping of the language function in the brain can be complemented with preoperative mapping with fMRI. The validity of an fMRI language localizer paradigm crucially depends on the choice of an optimal language task and baseline condition. This study presents a new fMRI language localizer in Russian using overt sentence completion, a task that comprehensively engages the language function by involving both production and comprehension at the word and sentence level. The paradigm was validated in 18 neurologically healthy volunteers who participated in two scanning sessions, for estimating test-retest reliability. For the first time, two baseline conditions for the sentence completion task were compared. At the group level, the paradigm significantly activated both anterior and posterior language-related regions. Individual-level analysis showed that activation was elicited most consistently in the inferior frontal regions, followed by posterior temporal regions and the angular gyrus. Test-retest reliability of activation location, as measured by Dice coefficients, was moderate and thus comparable to previous studies. Test-retest reliability was higher in the frontal than temporo-parietal region and with the most liberal statistical thresholding compared to two more conservative thresholding methods. Lateralization indices were expectedly left-hemispheric, with greater lateralization in the frontal than temporo-parietal region, and showed moderate test-retest reliability. Finally, the pseudoword baseline elicited more extensive and more reliable activation, although the syllable baseline appears more feasible for future clinical use. Overall, the study demonstrated the validity and reliability of the sentence completion task for mapping the language function in the brain. The paradigm needs further validation in a clinical sample of neurosurgical patients. Additionally, the study contributes to general evidence on test-retest reliability of fMRI.

show abstract

Left frontal aslant tract and lexical selection: Evidence from frontal lobe lesions

Cited by 11 publications

References 66 publications

A New Functional Magnetic Resonance Imaging Localizer for Preoperative Language Mapping Using a Sentence Completion Task: Validity, Choice of Baseline Condition, and Test–Retest Reliability

A New Functional Magnetic Resonance Imaging Localizer for Preoperative Language Mapping Using a Sentence Completion Task: Validity, Choice of Baseline Condition, and Test–Retest Reliability

Advancing Neurolinguistics in Russia: Experience and Implications of Building Experimental Research and Evidence-Based Practices

A new fMRI localizer for preoperative language mapping using a sentence completion task: Validity, choice of baseline condition, and test-retest reliability

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