Left ventricular deformation abnormalities in a patient with calpainopathy—a case from the three-dimensional speckle-tracking echocardiographic MAGYAR-Path Study

Nemes, Attila; Dézsi, Lívia; Domsik, Péter; Kalapos, Anita; Forster, Tamás; Vécsei, László

doi:10.21037/qims.2017.10.09

Cited by 9 publications

(14 citation statements)

References 26 publications

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“…In the presented case, both LV apical and basal rotations were in the same counterclockwise direction at rest confirming near absence of LV twist (LV-RBR). Recently, LV-RBR could be demonstrated in different cardiomyopathies [noncompaction (2-7); dilated (8) and hypertensive (9) with reduced systolic funtion], congenital heart diseases [hypoplastic right heart syndrome (10), univentricular heart (11), Ebstein anomaly (12)] and amyloidosis (13). Interestingly, in a woman with postpartum cardiomyopathy with noncompaction phenotype and LV-RBR, 6-month heart failure treatment was associated with reversal of LV-RBR proceeding normally directed LV rotations (7).…”

Section: Restmentioning

confidence: 99%

“…In some clinical circumstances, rotation at both basal and apical levels of the LV occurred in the same clockwise or counterclockwise direction during systole resulting the near absence of LV twist as called left ventricular "rigid body rotation" (LV-RBR) (2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13). Three-dimensional (3D) speckle-tracking echocardiography (STE) is a new technique with potential for noninvasive assessment of LV myocardial movements (14,15).…”

Section: Introductionmentioning

confidence: 99%

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Reversal of left ventricular “rigid body rotation” during dipyridamole-induced stress in a patient with stable angina: a case from the three-dimensional speckle tracking echocardiographic MAGYAR-Stress Study

Nemes¹,

Szántó²,

Kalapos³

et al. 2016

Quant. Imaging Med. Surg.

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Abstract:The left ventricular (LV) twist is defined as the wringing motion of the heart around its longaxis in systole caused by oppositely directed counterclockwise apical and clockwise basal rotations resulted from the movement of two orthogonally oriented muscular bands. In some clinical circumstances, rotation at both basal and apical levels of the LV occurred in the same clockwise or counterclockwise direction during systole resulting the near absence of LV twist as called left ventricular "rigid body rotation" (LV-RBR). Hereby we present that LV-RBR normalization of LV rotational mechanics could be demonstrated at maximum hyperaemia during dipyridamole-induced stress by three-dimensional (3D) speckle tracking echocardiography in a patient with stable angina.Keywords: Three-dimensional (3D); stress; speckle tracking; echocardiography; myocardial; mechanics; rigid body rotation Submitted Feb 25, 2016. Accepted for publication Mar 13, 2016Mar 13, . doi: 10.21037/qims.2016 (Motion Analysis of the heart and Great vessels bY threedimensionAl speckle-tRacking echocardiography during Stress protocols), in which among others drug-induced stress-related pathophysiologic consequences were aimed to be examined ('magyar' means 'Hungarian' in Hungarian language). Informed consent was obtained from the patient and the study protocol was approved by the institution's human research committee.Following complete two-dimensional (2D) Doppler echocardiography 3DSTE was performed with the same Toshiba Artida TM echocardiography equipment (Toshiba, Tokyo, Japan) using a 1-4 MHz matrix phased-array PST-25SX transducer (15). Six wedge-shaped subvolumes were acquired within a single breath-hold from the apical window to create full-volume 3D datasets at rest and at peak hyperaemia. Dipyridamole was used as a vasodilator stress agent using standard international protocols. During chamber quantifications 3D Wall Motion Tracking software version 2.7 was used. The apical two-(AP2CH) and four-chamber (AP4CH) views and three short-axis views at different LV levels from the LV base to apex were automatically selected from the 3D echocardiographic pyramidal dataset at end-diastole by the software. Two points of the LV endocardium at the edges of the mitral valve and one at the LV apex were marked manually on the AP2CH and AP4CH views. Then, the 3D endocardial surface was automatically reconstructed and tracked in 3D space throughout the cardiac cycle. Manual adjustments were also performed, if needed. Curves were generated by the software for quantification of global peak apical, midventricular and basal LV rotations at rest and at peak hyperaemia ( Figure 1). No wall motion abnormalities could be detected both in resting conditions and at peak hyperaemia by visual assessment suggesting a negative stress test result. Interestingly, apical and basal LV rotations were in the same counterclockwise direction suggesting LV-RBR at rest. At peak hyperaemia basal LV rotation become clockwisedirected, while apical rotation remained counterclock...

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Section: Restmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Reversal of left ventricular “rigid body rotation” during dipyridamole-induced stress in a patient with stable angina: a case from the three-dimensional speckle tracking echocardiographic MAGYAR-Stress Study

Nemes¹,

Szántó²,

Kalapos³

et al. 2016

Quant. Imaging Med. Surg.

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“…In our study, different infarct sizes were obtained, which in turn developed into different degrees of LV dysfunction, thus more closely resembling structural and functional characteristics of the dysfunction in human patients. Combined with the advanced clinical cardiac imaging techniques (36)(37)(38)(39)(40), this experimental LVSD platform in rabbits can be easily applied in clinically relevant imaging studies on translational cardiology and can help strengthen drug development and clinical research for the management of cardiovascular diseases. Recently, this platform has already been successfully applied in ongoing cardiac animal experiments (41,42).…”

Section: Discussionmentioning

confidence: 99%

Monitoring reperfused myocardial infarction with delayed left ventricular systolic dysfunction in rabbits by longitudinal imaging

Feng

Hemmeryckx

Frederix

et al. 2018

Quant. Imaging Med. Surg.

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Background: An experimental imaging platform for longitudinal monitoring and evaluation of cardiac morphology-function changes has been long desired. We sought to establish such a platform by using a rabbit model of reperfused myocardial infarction (MI) that develops chronic left ventricle systolic dysfunction (LVSD) within 7 weeks. Methods: Fifty-five New Zeeland white (NZW) rabbits received sham-operated or 60-min left circumflex coronary artery (LCx) ligation followed by reperfusion. Cardiac magnetic resonance imaging (cMRI), transthoracic echocardiography (echo), and blood samples were collected at baseline, in acute (48 hours or 1 week) and chronic (7 weeks) stage subsequent to MI for in vivo assessment of infarct size, cardiac morphology, LV function, and myocardial enzymes. Seven weeks post MI, animals were sacrificed and heart tissues were processed for histopathological staining. Results: The success rate of surgical operation was 87.27%. The animal mortality rates were 12.7% and 3.6% both in acute and chronic stage separately. Serum levels of the myocardial enzyme cardiac Troponin T (cTnT) were significantly increased in MI rabbits as compared with sham animals after 4 hours of operation (P<0.05). According to cardiac morphology and function changes, 4 groups could be distinguished: sham rabbits (n=12), and MI rabbits with no (MI_NO_LVSD; n=10), moderate (MI_M_LVSD; n=9) and severe (MI_S_LVSD; n=15) LVSD. No significant differences in cardiac function or wall thickening between sham and MI_NO_LVSD rabbits were observed at both stages using both cMRI and echo methods. cMRI data showed that MI_M_LVSD rabbits exhibited a reduction of ejection fraction (EF) and an increase in endsystolic volume (ESV) at the acute phase, while at the chronic stage these parameters did not change further. Moreover, in MI_S_LVSD animals, these observations were more striking at the acute stage followed by a further decline in EF and increase in ESV at the chronic stage. Lateral wall thickening determined by cMRI was significantly decreased in MI_M_LVSD versus MI_NO_LVSD animals at both stages (P<0.05). As for MI_S_LVSD versus MI_M_LVSD rabbits, the thickening of anterior, inferior and lateral walls was significantly more decreased at both stages (P<0.05). Echo confirmed the findings of cMRI. Furthermore, these in vivo outcomes including those from vivid cine cMRI could be supported by exactly matched ex vivo histomorphological evidences. Conclusions: Our findings indicate that chronic LVSD developed over time after surgery-induced MI in rabbits can be longitudinally evaluated using non-invasive imaging techniques and confirmed by the entireheart-slice histomorphology. This experimental LVSD platform in rabbits may interest researchers in the field of experimental cardiology and help strengthen drug development and translational research for the 755

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“…3DSTE-derived LV rotation and twist parameters have already been validated (14). It is known that LV twisting mechanism is affected by several conditions and disorders, but the results are conflicting (15)(16)(17). To this point, however, there is limited information on the relationship between CKD, KTx and LV rotational mechanics.…”

Section: Discussionmentioning

confidence: 99%

Left ventricular rotational abnormalities following successful kidney transplantation—insights from the three-dimensional speckle-tracking echocardiographic MAGYAR-Path Study

Borda

Kormányos

Domsik

et al. 2018

Quant. Imaging Med. Surg

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Background: Kidney transplantation (KTx) is the preferred treatment for virtually all suitable candidates with end-stage renal disease. There is limited information on left ventricular (LV) rotational mechanics post-KTx, therefore the present study aimed to assess it and to compare it to that of age-and gendermatched healthy controls. Methods: The present study comprised 42 KTx patients, from which 4 patients were excluded due to insufficient image quality (mean age: 46.3±8.2 years, 29 males). Control group consisted of 81 age-and gender-matched healthy individuals (mean age: 43.5±10.8 years, 51 males). All KTx patients and healthy controls successfully underwent transthoracic two-dimensional (2D) Doppler echocardiography and three-dimensional speckle-tracking echocardiography (3DSTE). Results: Significant differences could be demonstrated in LA diameter, LV end-diastolic diameter and volume, interventricular septum, LV posterior wall thickness, LV ejection fraction and early and late filling transmitral flow velocities and in their ratio between KTx patients and controls; none of the subjects examined showed grade 2-4 mitral and/or tricuspid regurgitations. Three patients following successful KTx showed near absence of LV twist called as LV 'rigid body rotation' (RBR) movement. When the remaining 35 post-KTx patients were analysed separately, reduced basal LV rotation could be demonstrated in post-KTx patients with tendentious increase in apical LV rotation resulting in an unchanged LV twist. Conclusions: KTx is associated with alterations in LV rotational mechanics with unchanged LV twist suggesting a remodelling of this sort of movement. The near absence of LV twist (LV-RBR) could be demonstrated in some post-KTx cases.

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Left ventricular deformation abnormalities in a patient with calpainopathy—a case from the three-dimensional speckle-tracking echocardiographic MAGYAR-Path Study

Cited by 9 publications

References 26 publications

Reversal of left ventricular “rigid body rotation” during dipyridamole-induced stress in a patient with stable angina: a case from the three-dimensional speckle tracking echocardiographic MAGYAR-Stress Study

Reversal of left ventricular “rigid body rotation” during dipyridamole-induced stress in a patient with stable angina: a case from the three-dimensional speckle tracking echocardiographic MAGYAR-Stress Study

Monitoring reperfused myocardial infarction with delayed left ventricular systolic dysfunction in rabbits by longitudinal imaging

Left ventricular rotational abnormalities following successful kidney transplantation—insights from the three-dimensional speckle-tracking echocardiographic MAGYAR-Path Study

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