Left Ventricular Deformation in Patients with Connective Tissue Disease: Evaluated by 3.0T Cardiac Magnetic Resonance Tissue Tracking

Wang, Jin; Shi, Ke; Xu, Huayan; Zhao, Qian; Liu, Xi; Gao, Yue; Yu, Hong; Guo, Yingkun; Yang, Zhi‐gang

doi:10.1038/s41598-019-54094-1

Cited by 5 publications

(5 citation statements)

References 35 publications

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“…In the present study, we found that compared with healthy individuals, the magnitude of global and regional LV longitudinal PS were decreased in IIM patients with preserved LVEF compared with the controls [25,26]. LV longitudinal PS contraction the longitudinal myocardial bers in the LV subendocardium, the most delicate layer to various stressors.…”

Section: Discussionmentioning

confidence: 61%

“…As such, the longitudinal strain parameters can reveal the subtle systolic dysfunction before the conventional changes in LVEF [8]. Impaired LV myocardial microvascular dysfunction in IIM patients has been reported, and abnormal LV myocardial deformation is associated with microvascular dysfunction in other diseases [25,27]. Thus, we speculate that the magnitude in reducing longitudinal myocardial strain in IIM patients in this study is related to LV myocardial microvascular ischemia.…”

Section: Discussionmentioning

confidence: 64%

“…In general, CMR-FT can accurately detect cardiac involvement in IIM patients. Combining global LV longitudinal PS with either of the models can increase the sensitivity and reliability of detecting cardiac involvement in IIM patients [25,26]. Incorporating LAVpre-ac indexed improved the sensitivity and accuracy of models 2 and 3.…”

Section: Discussionmentioning

confidence: 99%

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Early cardiac involvement detected by cardiac magnetic resonance feature tracking in idiopathic inflammatory myopathy with preserved ejection fraction

Liu

Zhu

Feng

et al. 2022

Int J Cardiovasc Imaging

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Cardiac involvement is a common but often subclinical phenomenon in idiopathic in ammatory myopathy (IIM). Cardiac magnetic resonance (CMR) is a promising tool for detecting cardiac involvement in IIM patients. In the present study, we assessed cardiac involvement in IIM patients using CMR feature tracking (CMR-FT). This was a retrospective study in which 37 IIM patients and 25 healthy controls were enrolled. The left ventricular (LV) functional parameters such as volume and ejection fraction (EF) were measured. Global and regional LV peak strain (PS) in radial, circumferential, and longitudinal directions were derived from cine images. Left atrial (LA) volume, longitudinal strain and strain rate (SR) parameters, LA reservoir function, conduit function, and booster pump function were also assessed. IIM patients with preserved LVEF showed signi cantly reduced global and regional LV PS in the longitudinal direction (all p < 0.05). Also, abnormal LA reservoir and conduit function were observed in IIM patients (p < 0.05). We found that global LV longitudinal PS was an independent predictor of IIM. Pearson's correlation analysis further revealed that the LV global radial, circumferential, and longitudinal PS in IIM patients signi cantly correlated with LVEF (r = 0.526, p < 0.001 vs. r=-0.514, p < 0.001 vs. r=-0.288, p = 0.023). CMR-FT-based LV and LA performance can early reveal cardiac involvement in IIM patients with preserved EF.

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Section: Discussionmentioning

confidence: 61%

Section: Discussionmentioning

confidence: 64%

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Early cardiac involvement detected by cardiac magnetic resonance feature tracking in idiopathic inflammatory myopathy with preserved ejection fraction

Liu

Zhu

Feng

et al. 2022

Int J Cardiovasc Imaging

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“…Tissue tracking with CMR has been increasingly used to quantitatively measure LV or RV strain parameters from the radial, circumferential, and longitudinal directions to assess ventricular function with excellent sensitivity and reproducibility (12,(22)(23)(24)(25). To our knowledge, this is the first study involving a comprehensive evaluation of biventricular strain and strain rate in SLE patients and their relationship with EF, LGE, PAH, pericardial effusion, and laboratory autoimmune antibodies.…”

Section: Discussionmentioning

confidence: 99%

Characterization and clinical significance of biventricular mechanics in patients with systemic lupus erythematosus by 3T cardiovascular magnetic resonance tissue tracking

Pu¹,

Cui²,

Liu³

et al. 2022

Quant Imaging Med Surg

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Background: Detecting impaired left ventricle (LV) or right ventricle (RV) mechanics could aid in fully understanding the process of cardiac involvement in patients with systemic lupus erythematosus (SLE). This study aimed to evaluate biventricular strain parameters derived from cardiac magnetic resonance (CMR) tissue tracking in SLE patients and their association with other clinical variables.Methods: A group of 47 SLE patients and 27 healthy controls were enrolled and underwent CMR examination, including cine and late gadolinium enhancement (LGE) imaging. Aside from RV strain parameters in the radial direction, biventricular global peak strain and peak systolic/diastolic global strain rate in radial, circumferential, and longitudinal directions were assessed for each participant. Multivariate linear regression analysis was used to analyze the factors related to the biventricular strain parameters.Receiver operating characteristic (ROC) analysis was used to identify RV dysfunction.Results: Compared with the controls, part of the biventricular strain parameters in the SLE subgroup with preserved ejection fraction (EF) were impaired, which was more significant in the SLE subgroup with reduced EF (all P<0.05). The SLE patients with RV dysfunction (15/47) included patients with LV dysfunction (8/47).The RVEF was associated with impaired LV global peak strain and peak diastolic strain rate in the SLE patients (absolute value of β=0.406-0.715, all P<0.05). The LV LGE in SLE patients (12/47) was associated with LV global longitudinal peak strain and peak diastolic global longitudinal strain rate (β=0.378 and −0.342; all P<0.05). There were independent correlations between pulmonary arterial hypertension and RV global longitudinal peak strain, anti-ribonucleoprotein (RNP) antibody and RV global circumferential peak strain, and pericardial effusion and RV peak diastolic global circumferential strain rate, respectively (β=0.319, 0.359, and −0.285, respectively; all P<0.05). The LV global longitudinal peak strain had greater diagnostic accuracy for RV dysfunction RV dysfunction [area under curve (AUC): 0.933, cut-off value: −13.38%).Conclusions: Biventricular strain parameters derived from CMR are sensitive markers of subclinical ventricular function impairment before EF reduction at an early stage of SLE. Biventricular strain analysis could be considered for inclusion in early cardiac functional assessment in SLE patients, particularly LV global longitudinal peak strain, which might assist in therapeutic decision-making and disease monitoring.

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“…The LVEF, LVEDV, and LVESV are the main indicators of the ability of the heart to pump blood; furthermore, they are important for evaluating coronary heart disease and predicting the survival rate of such patients[ 13 , 14 ]. The LVEF is the ratio of the left ventricular stroke volume to the end-diastolic volume, and it is one of the core values used for the basic evaluation of cardiac function in clinical practice[ 15 ].…”

Section: Discussionmentioning

confidence: 99%

Interaction between the left ventricular ejection fraction and left ventricular strain and its relationship with coronary stenosis

Gui¹,

Liu²,

Zhu³

2023

World J Clin Cases

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BACKGROUND Coronary artery stenosis (CAS) is the most common type of heart disease and the leading cause of death in both men and women globally. CAS occurs when the arteries that supply blood to the heart muscle harden and become narrower due to plaque buildup - cholesterol and other material - on their inner walls. As a result, the heart muscle cannot receive the blood or oxygen it needs. Most heart attacks happen when a blood clot suddenly cuts off the hearts' blood supply, causing permanent heart damage. AIM To analyze the relationship between the left ventricular ejection fraction (LVEF), left ventricular strain (LVS), and coronary stenosis. METHODS A total of 190 participants were enrolled in this trail. The control group comprised 93 healthy individuals, and observation group comprised 97 patients with coronary heart disease who were hospitalized between July 2020 and September 2021. Coronary lesions were assessed using the Gensini score, and the LVEF and LVS were measured using magnetic resonance imaging (MRI). The interaction between the LVEF and LVS was examined using a linear regression model. The relationship between LVEF and coronary stenosis was examined using Spearman’s correlation. RESULTS The LVEF of the observation group was lower than that of the control group. The left ventricular end-systolic volume (LVESV) and left ventricular end-diastolic volume (LVEDV) of the observation group were significantly higher than those of the control group ( P < 0.05). The longitudinal and circumferential strains (LS, CS) of the observation group were significantly higher than those of the control group; however, the radial strain (RS) of the observation group was significantly lower than that of the control group ( P < 0.05). LVS, LS, and CS were significantly negatively correlated with the LVEF, and RS was positively correlated with the LVEF. There were significant differences in the LVEF, LVESV, and LVEDV of patients with different Gensini scores; the LVEF significantly decreased and the LVESV and LVEDV increased with increasing Gensini scores ( P < 0.05). In the observation group, the LVEF was negatively correlated and the LVESV and LVEDV were positively correlated with coronary stenosis ( P < 0.05). CONCLUSION The LVEF measured using MRI is significantly linearly correlated with LVS and negatively correlated with coronary stenosis.

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Left Ventricular Deformation in Patients with Connective Tissue Disease: Evaluated by 3.0T Cardiac Magnetic Resonance Tissue Tracking

Cited by 5 publications

References 35 publications

Early cardiac involvement detected by cardiac magnetic resonance feature tracking in idiopathic inflammatory myopathy with preserved ejection fraction

Early cardiac involvement detected by cardiac magnetic resonance feature tracking in idiopathic inflammatory myopathy with preserved ejection fraction

Characterization and clinical significance of biventricular mechanics in patients with systemic lupus erythematosus by 3T cardiovascular magnetic resonance tissue tracking

Interaction between the left ventricular ejection fraction and left ventricular strain and its relationship with coronary stenosis

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