Left Ventricular Diastolic Filling in Young Persons With Type 1 Diabetes Mellitus

Berková, Marie; Opavský, J; Berka, Zdeněk; Skranka, Vladimír; Salinger, Jiří

doi:10.5507/bp.2003.008

Cited by 8 publications

(5 citation statements)

References 21 publications

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“…Also, as observed in patients with T2D, the most frequent cardiac abnormality in T1D was diastolic rather than systolic dysfunction, with respective prevalences of 27% and 12% in a prospective echocardiography study of 157 asymptomatic T1D patients [38]. Similar findings were provided by a similar trial demonstrating that diastolic parameters were altered in T1D: in young patients aged 20-32 years, their diastolic parameters corresponded to the normal values generally observed in healthy 8 50-year-olds, thereby suggesting an accelerated stiffening process in patients with T1D [39]. An echocardiography strain trial of children with T1D has also reinforced this insight.…”

Section: Insights From Type 1 Diabetessupporting

confidence: 67%

Diabetes-related cardiomyopathy: The sweet story of glucose overload from epidemiology to cellular pathways

Joubert

Manrique

Cariou

et al. 2019

Diabetes & Metabolism

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Section: Insights From Type 1 Diabetessupporting

confidence: 67%

Diabetes-related cardiomyopathy: The sweet story of glucose overload from epidemiology to cellular pathways

Joubert

Manrique

Cariou

et al. 2019

Diabetes & Metabolism

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“…It has been shown that type 1 diabetes negatively impacts echocardiographic parameters of diastolic function, in particular the E/A ratio (ratio of early diastolic filling/late diastolicfilling of the left ventricle) and transmitral blood flow velocity, as a sign of premature aging of the heart. The values measured in 20–32 year-old persons with type 1 diabetes corresponded with data obtained from healthy men at the age of 50 years, indicating an early onset of diastolic dysfunction in type 1 diabetes compared to a control population [27]. These findings were supported by a study performed on 8–18 year-old children and young adolescents with a mean diabetes duration of 5.6 years who showed reduced diastolic function with higher peak a′-velocity and reduced e′/a′-ratio, indicating impaired diastolic function after a short duration of disease.…”

Section: Diabetic Cardiomyopathy In Type 1 Diabetes?supporting

confidence: 61%

Diabetic Cardiomyopathy: Does the Type of Diabetes Matter?

Hölscher

Bode

Bugger

2016

IJMS

139

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In recent years, type 2 diabetes mellitus has evolved as a rapidly increasing epidemic that parallels the increased prevalence of obesity and which markedly increases the risk of cardiovascular disease across the globe. While ischemic heart disease represents the major cause of death in diabetic subjects, diabetic cardiomyopathy (DC) summarizes adverse effects of diabetes mellitus on the heart that are independent of coronary artery disease (CAD) and hypertension. DC increases the risk of heart failure (HF) and may lead to both heart failure with preserved ejection fraction (HFpEF) and reduced ejection fraction (HFrEF). Numerous molecular mechanisms have been proposed to underlie DC that partially overlap with mechanisms believed to contribute to heart failure. Nevertheless, the existence of DC remains a topic of controversy, although the clinical relevance of DC is increasingly recognized by scientists and clinicians. In addition, relatively little attention has been attributed to the fact that both underlying mechanisms and clinical features of DC may be partially distinct in type 1 versus type 2 diabetes. In the following review, we will discuss clinical and preclinical literature on the existence of human DC in the context of the two different types of diabetes mellitus.

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“…Although many investigators demonstrated some differences in the parameters of diastolic function and NT-proBNP levels between small groups of patients with type 1 diabetes without cardiovascular disorders and non-diabetic controls, none of them reported the prevalence and incidence rates of MD and HF [23–28]. Our study, similarly to some others, focused on normal diastolic function in type 1 diabetic patients [29, 30].…”

Section: Discussionmentioning

confidence: 67%

Myocardial dysfunction and chronic heart failure in patients with long-lasting type 1 diabetes: a 7-year prospective cohort study

Konduracka

Cieslik²,

Galicka-Latała

et al. 2013

Acta Diabetol

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The aim of the study is to evaluate the prevalence and incidence of myocardial dysfunction (MD) and heart failure (HF) in long-lasting (≥10 years) type 1 diabetes without cardiovascular disorders or with hypertension or coronary heart disease (CHD). The study included 1,685 patients with type 1 diabetes (mean baseline age, 51 years; diabetes duration, 36 years). In all patients, echocardiography was performed, NT-proBNP levels were measured, and clinical symptoms were evaluated. A 7-year follow-up was conducted to monitor systolic and diastolic manifestations of MD and HF. At the end of the follow-up period, the prevalence of HF in the entire group was 3.7 %, and the incidence was 0.02 % per year. The prevalence of MD was 14.5 % and the incidence –0.1 % per year. MD and HF were observed only in hypertensive or CHD patients. At baseline, subjects with diastolic HF constituted 85 % of the HF population and those with systolic HF the remaining 15 %. Baseline HF predictors included age, diabetes duration, HbA1c levels, CHD, systolic blood pressure >140 mmHg, and GFR <60 mL/min/1.73 m2. In patients with type 1 diabetes, MD and HF occurred only when diabetes coexisted with cardiovascular disorders affecting myocardial function. The prevalence and incidence of HF in patients with hypertension and CHD were relatively low. While the cause of this observation remains uncertain, it could probably be explained, at least partially, by the cardioprotective effect of concomitant treatment.

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Left Ventricular Diastolic Filling in Young Persons With Type 1 Diabetes Mellitus

Cited by 8 publications

References 21 publications

Diabetes-related cardiomyopathy: The sweet story of glucose overload from epidemiology to cellular pathways

Diabetes-related cardiomyopathy: The sweet story of glucose overload from epidemiology to cellular pathways

Diabetic Cardiomyopathy: Does the Type of Diabetes Matter?

Myocardial dysfunction and chronic heart failure in patients with long-lasting type 1 diabetes: a 7-year prospective cohort study

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