Left Ventricular End-Diastolic Volume from Ejection Fraction and Stroke Volume in Pigs during IVC Occlusion

Gallup, Cecily J.; Cabreriza, Santos E.; Hart, Joseph P.; Walsh, Rowan; Weinberg, Alan; Spotnitz, Henry M.

doi:10.1006/jsre.2002.6432

Cited by 3 publications

(2 citation statements)

References 18 publications

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“…These calculations are based on our prior validation studies. 4 Our sonomicrometry data suggest that optimized timings during BiVP improve LV mechanics by increasing EDD and decreasing ESD. The resolution required to fully define the mechanisms underlying these changes will require more sophisticated technology than used here.…”

Section: Discussionmentioning

confidence: 67%

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Mechanisms of Optimized Biventricular Pacing in Pulmonary Stenosis:

Rabkin¹,

Cabreriza²,

Curtis³

et al. 2004

Pacing Clinical Electrophis

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We tested the hypothesis that optimized biventricular pacing (BiVP) enhances cardiac output (CO) during critical pulmonary stenosis (PS) by attenuating distortions in left ventricular (LV) geometry. Following median sternotomy in six anesthetized pigs, heart block was induced by ethanol ablation. During epicardial, DDD BiVP, atrioventricular delay (AVD) was varied from 60 ms to 180 ms in 30 ms increments. At the AVD with the highest CO right-left delay (RLD) was varied from (+) 80 ms (RV first) to (-) 80 ms (LV first) in 20 ms increments. At each pacing setting, aortic flow, ECG, and LV diameter were measured in the control state (CON) and during PS, created by snaring the pulmonary artery until CO decreased 50%. Short axis LV echocardiograms were obtained at (+) and (-) 80 ms. In CON, RLD had no effect on function or geometry. During PS optimum BiVP resulted in significant increases in CO (1.12 L/min +/- 0.13 SEM at RLD =+ 40 ms versus 0.92 +/- 0.12 at RLD = 0 and 0.73 +/- 0.08 at RLD =-80), and LV fractional shortening (8.97%+/- 0.51% at RLD =+ 40 ms versus 7.34%+/- 0.58% at RLD = 0 and 6.21%+/- 0.66% at RLD =-80). In addition, LV eccentricity with (-) RLD was significantly different versus CON at both end-diastole (0.79 +/- 0.07 vs 1.02 +/- 0.03, P = 0.011 Student's t-test) and end-systole (0.83 +/- 0.05 vs 1.00 +/- 0.02, P = 0.017). However, with (+) RLD differences versus CON were not significant at either end-diastole (0.88 +/- 0.06 vs 0.99 +/- 0.03) or end-systole (0.92 +/- 0.03 vs 1.01 +/- 0.03). In swine hearts with PS, optimized BiVP increases CO, fractional shortening, and LV symmetry. BiVP warrants further study as treatment for acute postoperative heart failure.

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Section: Discussionmentioning

confidence: 67%

“…LVEDV is estimated to increase from 38.8 to 40.1 mL in control and 20.3 to 23.8 mL in PS, as RLD changes from (−) 80 to (+) 80 ms (Table III). These calculations are based on our prior validation studies 4 . Our sonomicrometry data suggest that optimized timings during BiVP improve LV mechanics by increasing EDD and decreasing ESD.…”

Section: Discussionmentioning

confidence: 95%

Mechanisms of Optimized Biventricular Pacing in Pulmonary Stenosis:

Rabkin¹,

Cabreriza²,

Curtis³

et al. 2004

Pacing Clinical Electrophis

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Keeping Donor Hearts in Completely Beating Status With Normothermic Blood Perfusion for Transplants

Yang¹,

Lin²,

Wen³

et al. 2013

The Annals of Thoracic Surgery

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High-frame-rate Volumetric Porcine Cardiac Imaging

Wei,

Wahyulaksana,

Hekkert

et al. 2023

2023 IEEE International Ultrasonics Symposium (IUS)

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Volumetric echocardiography can potentially give a more complete picture of cardiac dynamics than its twodimensional (2D) counterpart. Current clinical volumetric imaging probes have relatively low frame rates, and often require ECG gating to stitch together an entire volume. This makes measuring fast dynamics of the heart as well as imaging patients with irregular heartbeats difficult. We have previously designed and manufactured 2D sparse arrays with elements seeded in a density-tapered spiral pattern for cardiac imaging. Using these prototypes, we demonstrate in this paper the first high-framerate volumetric closed-chest porcine cardiac as well as open-chest myocardial blood flow results. These preliminary results suggest the potential of performing high-frame-rate volumetric cardiac imaging using the sparse spiral arrays.

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Left Ventricular End-Diastolic Volume from Ejection Fraction and Stroke Volume in Pigs during IVC Occlusion

Cited by 3 publications

References 18 publications

Mechanisms of Optimized Biventricular Pacing in Pulmonary Stenosis:

Mechanisms of Optimized Biventricular Pacing in Pulmonary Stenosis:

Keeping Donor Hearts in Completely Beating Status With Normothermic Blood Perfusion for Transplants

High-frame-rate Volumetric Porcine Cardiac Imaging

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