Left ventricular hypertrophy and outcomes: A five-year retrospective analysis of patients with essential hypertension

Барсуков, А. В.; Зобнина, М. П.; Таланцева, М С

doi:10.18705/1607-419x-2012-18-5-385-397

Cited by 3 publications

(1 citation statement)

References 43 publications

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“…Известно, что длительное повышение продукции ренина, ангиотензина II и активация симпатической нервной системы способствуют развитию гипертрофии МЛЖ [16]. В свою очередь ремоделирование миокарда на фоне АГ является серьезным предиктором смертности от ССЗ [17]. Существуют данные, что у реконвалесцентов инфекции COVID-19 наблюдается увеличение внешней и внутренней площади МЛЖ и ММЛЖ, что ведет к увеличению частоты ССЗ [18].…”

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Associations of arterial hypertension and the severity of the course of a new coronavirus infection

Tuzovskaya

Evdokimova

Striukova

et al. 2023

jour

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Discussions continue about the effect of arterial hypertension (AH) on the course and prognosis of COVID-19 infection, while interest in the effect of antihypertensive therapy (AHT), primarily angiotensin converting enzyme inhibitors (ACEI) and angiotensin receptor blockers (ARB), on the course of the disease does not weaken. Aim of the study was to investigate the associations of AH, AHT and the severity of the course of coronavirus infection in Novosibirsk patients. Material and methods. Study design: a single-stage observational study. The study included 268 patients aged 26–84 years (47.5 % men) who underwent COVID-19. All patients underwent anthropometry, echocardiography, and anamnesis data were evaluated. Laboratory studies were carried out using enzyme immunoassay. Results. Patients with AH and moderate/severe COVID-19 had higher values of glucose, body mass index (BMI), waist circumference (WC), and left ventricular mass in terms of height (LVM/height) than patients with mild course. Diastolic blood pressure was significantly less in moderate and severe course than in mild course. The chance of severe COVID-19 in patients with AH is 11 % higher with an increase in BMI by 1 kg/m2 (1.110, 95 % CI 1.042–1.182, p = 0.001), by 3.9 % with an increase of 1 cm (1.039, 95 % CI, 1.013–1.066, p = 0.003). Regular use of AHT reduced the chance of severe COVID-19 by 2.3 times. Conclusions. In patients with AH, glucose levels, WC, BMI, and LVL/height are associated with a more severe course of COVID-19. The chance of having a moderate and severe course of COVID-19 in patients with AH is 11% higher with an increase in BMI by 1 kg/m2, by 3.9 % with an increase of 1 cm. With regular AHT, the chance of moderate and severe COVID-19 decreased 2.3 times.

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Section: Discussionunclassified

Associations of arterial hypertension and the severity of the course of a new coronavirus infection

Tuzovskaya

Evdokimova

Striukova

et al. 2023

jour

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Left ventricular hypertrophy as a marker of adverse cardiovascular risk in persons of different age groups

et al. 2015

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Laboratory and instrumental parameters associated with the risk of death in the long-term follow-up period in patients after myocardial infarction

Mushikhina,

Gorbatenko,

Teploukhova

et al. 2024

Kazan Med J

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BACKGROUND: In patients who successfully survived the 1st year after myocardial infarction, the risk of death remains elevated. AIM: To determine laboratory and instrumental parameters of myocardial remodeling associated with a lethal outcome in the long-term follow-up period in patients 1 year after myocardial infarction. MATERIAL AND METHODS: The study included 184 patients 12 months after myocardial infarction: the first group — living patients at the 5-year follow-up point (n=160), the second group — deceased patients at the 5-year follow-up point (n=24). A comparative analysis of inflammation and myocardial dysfunction biomarkers, as well as echocardiographic parameters reflecting the types of left ventricular remodeling, linear dimensions of the cavities and wall thickness of the heart, chamber volumes, and ventricular systolic function was retrospectively performed. After assessing the distribution of quantitative data, the Student's t-test or Mann–Whitney U-test and the χ2 criterion for categorical data were used. The model was built on the basis of logistic regression. The ROC curve, the Hosmer–Lemeshow test, and the bootstrap method were used to assess the model itself and its reliability. RESULTS: Patients in the second group were older (p=0.007), and more often had myocardial infarction with ST-segment elevation during hospitalization (p 0.001). Twelve months after myocardial infarction, a multidirectional pattern of changes in the level of N-terminal brain natriuretic propeptide was revealed: a decrease was registered in the first group, while an increase was registered in the second group. In the dynamics of the second group, the index of end-diastolic volume (p=0.014) and the size of left ventricular asynergy were higher (p=0.043), and the ejection fraction was lower (p=0.015) than in the first group. The model for predicting 4-year mortality in patients who survived myocardial infarction during the 1st year included such parameters as the index of the left ventricular end-diastolic volume, the content of the N-terminal fragment of the natriuretic peptide and the presence of concentric hypertrophy of the left ventricle. CONCLUSION: In patients who survived 1 year after myocardial infarction, the long-term risk of death is associated with a set of parameters reflecting left ventricular remodeling and the development of heart failure.

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Left ventricular hypertrophy and outcomes: A five-year retrospective analysis of patients with essential hypertension

Cited by 3 publications

References 43 publications

Associations of arterial hypertension and the severity of the course of a new coronavirus infection

Associations of arterial hypertension and the severity of the course of a new coronavirus infection

Left ventricular hypertrophy as a marker of adverse cardiovascular risk in persons of different age groups

Laboratory and instrumental parameters associated with the risk of death in the long-term follow-up period in patients after myocardial infarction

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