Left Ventricular Hypertrophy in Patients with Chronic Bronchitis and Emphysema

Murphy, Marvin L.; Adamson, James S.; Hutcheson, Fred

doi:10.7326/0003-4819-81-3-307

Cited by 69 publications

(17 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In conclusion, we agree with the authors who state that the association between pulmonary emphysema and left ventricular hypertrophy is an undecided question [17], with obscure causes [19], requiring further investigations.…”

Section: Commentscontrasting

confidence: 44%

“…MURPHY et al [19] claimed that the incidence of left ventricular hypertrophy in patients with pulmonary emphysema varies in different publications, affecting between 24 and 86% of patients. Although some postmortem studies [17,20] have reported left ventricular hypertrophy in patients with COPD, works performed using non-invasive methods and catheterization demonstrated normal sizes and functioning in these patients [21].…”

Section: Commentsmentioning

confidence: 99%

See 1 more Smart Citation

Avaliação das alterações morfológicas cardíacas secundárias ao enfisema pulmonar: estudo experimental em ratos

Monteiro

Jatene

Pazetti

et al. 2004

Rev Bras Cir Cardiovasc

View full text Add to dashboard Cite

Abstract:Objective: The purpose of this study is to evaluate the occurrence and repercussions of chemically induced pulmonary emphysema and the morphological alterations present in rats' hearts of post-induction and to follow the progression afterwards.Method: Seventy five rats divided into two groups: papain (N=50) and control (N=25), were submitted to intratracheal spraying of papain and saline solution, respectively, and were evaluated. The animals were sacrificed 30, 60, 90, 120 or 180 days post-spraying. Arterial blood gases and cardiac and pulmonary morphometrical analysis were performed.Results: Papain spraying produced alveolar tissue destruction similar to the morphological alterations observed in pulmonary emphysema. The papain group presented mean alveolar diameter higher than controls in all periods evaluated (p<0.05). Right ventricle wall thickness and interventricular septum did not show significant macroscopic alterations until six months after emphysema induction. The right ventricle area presented enlargement 120 days after induction of pulmonary emphysema, with mean area higher than controls at 120 and 180 days (p=0.001). The left ventricle presented significant cavity area decrease 90 days after induction of the pulmonary emphysema, followed by slight wall thickening.Conclusions: The adopted experimental model was efficient to morphologically induce pulmonary emphysema. The presence of pulmonary emphysema did not provoke morphological changes in the right ventricle wall and interventricular septum. The alveolar destruction induced left ventricular hypertrophy and enlargement of the right ventricle.Descriptors: Pulmonary emphysema, chemically induced. Pulmonary emphysema, physiopathology. Papain, pharmacology. Disease models, animal. Heart ventricle, anatomy & histology.Avaliação das alterações morfológicas cardíacas secundárias ao enfisema pulmonar: estudo experimental em ratos Evaluation of the cardiac morphological alterations secondary to the pulmonary emphysema: experimental study in rats 342 MONTEIRO, R ET AL -Evaluation of the cardiac morphological alterations secondary to the pulmonary emphysema: experimental study in rats Braz

show abstract

Section: Commentscontrasting

confidence: 44%

Section: Commentsmentioning

confidence: 99%

Avaliação das alterações morfológicas cardíacas secundárias ao enfisema pulmonar: estudo experimental em ratos

Monteiro

Jatene

Pazetti

et al. 2004

Rev Bras Cir Cardiovasc

View full text Add to dashboard Cite

show abstract

“…In an autopsy series, 40% of the patients with COPD were diagnosed to have cor pulmonale [26], and about 85% of the patients with cor pulmonale had COPD [25]. Left ventricle functions were found to remain normal in COPD in some studies, while others claim that LV dysfunction may be present [27,28].…”

Section: Discussionmentioning

confidence: 99%

Echocardiographic evaluation of right and left heart findings according to the severity of the disease in stable chronic obstructive pulmonary disease

Mutlu¹,

Akşıt²,

N³

2018

biomedicalresearch

View full text Add to dashboard Cite

Introduction: Chronic Obstructive Pulmonary Disease (COPD) is seen alongside some systemic diseases that result in impaired functional capacity, worsening dyspnea, decreased health-related quality of life and increased mortality. Cardiovascular diseases, considering their effect on mortality, play an important role in such diseases. Objective: The aim of this study to evaluate the cardiac changes that develop secondary to COPD and attempt to identify any correlation between the severities of the disease determined using GOLD guidelines and ECHO findings. Method: This prospective study involved 32 male patients who presented to the pulmonary disease outpatient clinic with stable COPD. We compared the severity of COPD with the ECO findings of the patients. Findings: Correlations were found between the severity of COPD and heart rate, the number of cigarettes smoked and the respiratory function test results. Measurable tricuspid regurgitation was detected in 26 patients (26/32=81.2%), and the degree of tricuspid regurgitation according to the severity of COPD. Conclusion: We suggest that cardiac influences should be diagnosed early in the course of the disease, and that treatment be started to decrease the rates of mortality and morbidity in patients with COPD.

show abstract

“…Some study indicate that LV function remains normal in persions with COPD , whereas others suggest that LV dysfunction may be present 16,17 .…”

Section: Discussionmentioning

confidence: 99%

Echocardiographical Evaluation And Cardiovascular Changes In Chronic Obstructive Pulmonary Disease Patients In Tertiary Care Hospital

Saurabh¹

2016

jmscr

View full text Add to dashboard Cite

Left Ventricular Hypertrophy in Patients with Chronic Bronchitis and Emphysema

Cited by 69 publications

References 30 publications

Avaliação das alterações morfológicas cardíacas secundárias ao enfisema pulmonar: estudo experimental em ratos

Avaliação das alterações morfológicas cardíacas secundárias ao enfisema pulmonar: estudo experimental em ratos

Echocardiographic evaluation of right and left heart findings according to the severity of the disease in stable chronic obstructive pulmonary disease

Echocardiographical Evaluation And Cardiovascular Changes In Chronic Obstructive Pulmonary Disease Patients In Tertiary Care Hospital

Contact Info

Product

Resources

About