Left Ventricular Hypertrophy Is Associated with Arterial Stiffness and Vascular Calcification in Hemodialysis Patients

Nitta, Kosaku; Akiba, Takashi; Uchida, Keiko; Otsubo, Shigeru; Otsubo, Yuriko; Takei, Takashi; Ogawa, Tetsuya; Yumura, Wako; Kabaya, Takashi; Nihei, Hiroshi

doi:10.1291/hypres.27.47

Cited by 147 publications

(130 citation statements)

References 33 publications

Supporting

Mentioning

109

Contrasting

Unclassified

Order By: Relevance

“…Elevated Ca ϫ PO 4 is a risk factor for arterial calcification (26,27). Previous studies demonstrated a potential role of PTH in promoting myocardial fibrosis (8), but our data showed no correlation between LVMI and PTH.…”

Section: Pre-hd Bp and Ca ϫ Po 4 : Increased Afterloadcontrasting

confidence: 73%

Determinants of Left Ventricular Mass and Hypertrophy in Hemodialysis Patients Assessed by Cardiac Magnetic Resonance Imaging

Patel

Oliver

Mark

et al. 2009

Clinical Journal of the American Society of Nephrology

View full text Add to dashboard Cite

Section: Pre-hd Bp and Ca ϫ Po 4 : Increased Afterloadcontrasting

confidence: 73%

Determinants of Left Ventricular Mass and Hypertrophy in Hemodialysis Patients Assessed by Cardiac Magnetic Resonance Imaging

Patel

Oliver

Mark

et al. 2009

Clinical Journal of the American Society of Nephrology

View full text Add to dashboard Cite

“…There is controversy over the effect of disorders of lipid metabolism on aortic compliance. In several cross-sectional studies, lipid profile was not a determinant of PWV, 5,6,9,29 whereas serum triglyceride correlated positively with ba-PWV in hemodialysis patients 30 and increments in ba-PWV. 28 Furthermore, intermediate-density lipoprotein cholesterol, which contains cholesterol and triglyceride, was an independent risk factor for arteriosclerosis.…”

Section: Discussionmentioning

confidence: 88%

What factors accelerate aortic stiffening in hemodialysis patients? An observational study

Matsumae¹,

Abe

Nishimura³

et al. 2010

Hypertens Res

View full text Add to dashboard Cite

Increased aortic stiffness is an independent predictor of death from cardiovascular disease in patients with end-stage renal disease (ESRD). Various factors that contribute to carotid-femoral pulse wave velocity (cfPWV) as a surrogate of aortic stiffness have been identified, but determinants of long-term worsening of aortic stiffness remain to be elucidated. To clarify the factors that accelerate aortic stiffness in hemodialysis patients, 148 patients with ESRD on hemodialysis were evaluated. At baseline, cfPWV and ankle-brachial blood pressure index (ABPI) were measured and clinical status including biochemical parameters, with or without hepatitis c virus (HCV) infection, diabetes mellitus (DM), cardiovascular disease, cerebrovascular disease and peripheral arterial disease at baseline, were evaluated. The cfPWV was measured again after a 3-year follow up and the annual change in cfPWV was calculated. The cfPWV decreased in 54 patients, worsened slowly in 47 (annual change in cfPWV ranged from 0 to 0.33 m s À1 per year), and worsened rapidly in 47 patients (annual change in cfPWV was more than 0.33 m s À1 per year). The prevalences of DM, HCV infection and peripheral arterial disease were the highest in the rapid progression group. Univariate analysis showed that age, high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), LDL-C/HDL-C ratio, HCV infection, ABPI and number of vasculopathies were significantly associated with annual change in cfPWV. Stepwise regression analysis identified ABPI, LDL-C/HDL-C ratio and HCV infection as independent determinants of worsening of cfPWV. Further studies are needed to investigate the mechanism of HCV-related enhancement of aortic stiffness in ESRD patients.

show abstract

“…It has been found in several studies that pulse wave velocity correlates with the degree of left ventricular hypertrophy (20,21). Although left ventricular hypertrophy is assessed by measuring the left ventricular mass index by echocardiography, it is time-consuming to calculate the value.…”

Section: Discussionmentioning

confidence: 99%

Relationships between Echocardiographic Findings, Pulse Wave Velocity, and Carotid Atherosclerosis in Type 2 Diabetic Patients

et al. 2005

View full text Add to dashboard Cite

show abstract

Left Ventricular Hypertrophy Is Associated with Arterial Stiffness and Vascular Calcification in Hemodialysis Patients

Abstract: Left ventricular hypertrophy (LVH) is the most frequent cardiac abnormality in patients with end-stage renal disease (ESRD).

Cited by 147 publications

References 33 publications

Determinants of Left Ventricular Mass and Hypertrophy in Hemodialysis Patients Assessed by Cardiac Magnetic Resonance Imaging

Determinants of Left Ventricular Mass and Hypertrophy in Hemodialysis Patients Assessed by Cardiac Magnetic Resonance Imaging

What factors accelerate aortic stiffening in hemodialysis patients? An observational study

Relationships between Echocardiographic Findings, Pulse Wave Velocity, and Carotid Atherosclerosis in Type 2 Diabetic Patients

Contact Info

Product

Resources

About