Left ventricular noncompaction cardiomyopathy in end-stage heart failure patients undergoing orthotopic heart transplantation

Ottaviani, Giulia; Segura, Ana; Rajapreyar, Indranee; Zhao, Bihong; Radovancevic, Rajko; Loyalka, Pranav; Kar, Biswajit; Gregorič, Igor D.; Buja, L. M.

doi:10.1016/j.carpath.2016.03.004

Cited by 22 publications

(8 citation statements)

References 25 publications

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“…Prominent trabeculation exceeding this diagnostic ratio can also be found in 27.5% of the healthy adult population without loss of left ventricular function over time [3]. However, patients with LVNC can develop congestive heart failure in 30% to 50% of cases, and it was found in 0.95-3.8% of explanted hearts after orthotopic heart transplantations [4][5][6].…”

Section: Introductionmentioning

confidence: 99%

Changes in strain parameters at different deterioration levels of left ventricular function: A cardiac magnetic resonance feature-tracking study of patients with left ventricular noncompaction

Szũcs¹,

Kiss²,

Gregor³

et al. 2021

International Journal of Cardiology

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Background: There is a lack of cardiac MRI information on left ventricular (LV) strain and rotational parameters of left ventricular noncompaction (LVNC) patients with reduced ejection fraction (EF). Thus, we sought to use feature tracking (FT) to describe these changes at different levels of EF deterioration. Methods: We included 31 adult LVNC patients with reduced LV EF (Group B, EF < 50%) without any comorbidities or concomitant cardiac diseases, 31 age-and sex-matched LVNC patients with good EF (Group A, EF > 50%) and 31 healthy controls. Group B was divided according to LV EF into two subgroups (Group B-1: EF 35-50%, Group B-2: EF < 35%). Their global longitudinal, circumferential (GCS), and radial (GRS) strains; LV segmental strains; LV apical and basal rotation values; and patterns and degree of LV dyssynchrony were measured. Results: All of the global and mean segmental strain parameters were significantly worse in Groups B, B-1 and B-2 than in Group A and in the controls. The LV mechanical dispersion increased as LV EF decreased. The degree of apical rotation was the highest in the control group, almost the same in Group A and the lowest and in the reverse direction in Group B-2. A rotational pattern, clockwise-directed rigid body rotation (RBR), was found in 39% of the Group B patients, and a counterclockwise-directed RBR was found in 26% of the Group A patients. Conclusions: The strain values and rotational parameters changed as the EF decreased. These changes affected the global LV, and we did not identify an LVNC-specific strain pattern.

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Section: Introductionmentioning

confidence: 99%

Changes in strain parameters at different deterioration levels of left ventricular function: A cardiac magnetic resonance feature-tracking study of patients with left ventricular noncompaction

Szũcs¹,

Kiss²,

Gregor³

et al. 2021

International Journal of Cardiology

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“…Burke et al [4,44] did not found any difference between isolated LVNC and associated with CHD. Although Jenni et al [17] claimed that no disarray was present, a recent transplantation series found it in one LVNC patient [59]. Proper myocyte description beyond isolated cases is also missing [59,61,62], and no genetic data are reported in any series.…”

Section: Discussionmentioning

confidence: 99%

“…Although Jenni et al [17] claimed that no disarray was present, a recent transplantation series found it in one LVNC patient [59]. Proper myocyte description beyond isolated cases is also missing [59,61,62], and no genetic data are reported in any series. For this reason, the APE description of our sample, although small, is important.…”

Section: Discussionmentioning

confidence: 99%

“…In LVNC, APE data have been focused in compaction/non-compaction layers description and quantification [4,44], neglecting meticulous histopathological description [4,57]. Fibrosis areas considered secondary to ischemia due to microvascular dysfunction are described in some studies [58][59][60]. Burke et al [4,44] did not found any difference between isolated LVNC and associated with CHD.…”

Section: Discussionmentioning

confidence: 99%

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Characterization of Left Ventricular Non-Compaction Cardiomyopathy

Lorca

Martı́n

Pascual

et al. 2020

JCM

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Left ventricle non-compaction cardiomyopathy (LVNC) has gained great interest in recent years, being one of the most controversial cardiomyopathies. There are several open debates, not only about its genetic heterogeneity, or about the possibility to be an acquired cardiomyopathy, but also about its possible overdiagnosis based on imaging techniques. In order to better understand this entity, we identified 38 LVNC patients diagnosed by cardiac MRI (CMRI) or anatomopathological study that could underwent NGS-sequencing and clinical study. Anatomopathological exam was performed in eight available LVNC hearts. The genetic yield was 34.2%. Patients with negative genetic testing had better left ventricular ejection fraction (LVEF) or it showed a tendency to improve in follow-up, and a possible trigger factor for LVNC was identified in 1/3 of them. Nonetheless, cerebrovascular accidents occurred in similar proportions in both groups. We conclude that in LVNC there seem to be different ways to achieve the same final phenotype. Genetic testing has a good genetic yield and provides valuable information. LVNC without an underlying genetic cause may have a better prognosis in terms of LVEF evolution. However, anticoagulation to prevent cerebrovascular accident (CVA) should be carefully evaluated in all patients. Larger series with pathologic examination are needed to help better understand this entity.

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“…É importante salientar que tais resultados estão alinhados com estudos anatomopatológicos anteriores que documentaram alterações intersticiais difusas (fibrose microscópica) em corações com MNC (20,26) .…”

Section: Características Clínicasunclassified

Quantificação do mapa T1 e do volume extracelular miocárdico por ressonância magnética em pacientes com miocardiopatia não compactada

Filho¹,

Batista²

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Left ventricular noncompaction cardiomyopathy in end-stage heart failure patients undergoing orthotopic heart transplantation

Cited by 22 publications

References 25 publications

Changes in strain parameters at different deterioration levels of left ventricular function: A cardiac magnetic resonance feature-tracking study of patients with left ventricular noncompaction

Changes in strain parameters at different deterioration levels of left ventricular function: A cardiac magnetic resonance feature-tracking study of patients with left ventricular noncompaction

Characterization of Left Ventricular Non-Compaction Cardiomyopathy

Quantificação do mapa T1 e do volume extracelular miocárdico por ressonância magnética em pacientes com miocardiopatia não compactada

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